Can home-monitoring of sleep predict depressive episodes in bipolar patients?

The aim of this study is the evaluation of the autonomic regulations during depressive stages in bipolar patients in order to test new quantitative and objective measures to detect such events. A sensorized T-shirt was used to record ECG signal and body movements during the night, from which HRV data and sleep macrostructure were estimated and analyzed. 9 out of 20 features extracted resulted to be significant (p<;0.05) in discriminating among depressive and non-depressive states. Such features are representation of HRV dynamics in both linear and non-linear domain and parameters linked to sleep modulations.

[1]  Sue Wilson,et al.  Sleep disorders as core symptoms of depression , 2008, Dialogues in clinical neuroscience.

[2]  Claudio Gentili,et al.  Clinical state assessment in bipolar patients by means of HRV features obtained with a sensorized T-shirt , 2012, 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[3]  M. P. Griffin,et al.  Sample entropy analysis of neonatal heart rate variability. , 2002, American journal of physiology. Regulatory, integrative and comparative physiology.

[4]  R. Paradiso,et al.  Wearable monitoring systems for psychological and physiological state assessment in a naturalistic environment , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[5]  A Voss,et al.  Linear and nonlinear methods for analyses of cardiovascular variability in bipolar disorders. , 2006, Bipolar disorders.

[6]  Gwilym M. Jenkins,et al.  Time series analysis, forecasting and control , 1971 .

[7]  W. Zareba,et al.  Heart rate variability. , 2013, Handbook of clinical neurology.

[8]  Martin P Paulus,et al.  Heart rate variability in bipolar mania and schizophrenia. , 2010, Journal of psychiatric research.

[9]  R. Mantegna,et al.  Fractals in biology and medicine. , 1995, Chaos, solitons, and fractals.

[10]  Franco Benazzi,et al.  Bipolar disorder—focus on bipolar II disorder and mixed depression , 2007, The Lancet.

[11]  J. Markowitz,et al.  The 16-Item quick inventory of depressive symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression , 2003, Biological Psychiatry.

[12]  D. J. Lynn Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression, 2nd ed , 2009 .

[13]  A. Malliani,et al.  Heart rate variability. Standards of measurement, physiological interpretation, and clinical use , 1996 .