Optimal design of focused arrays for microwave-induced hyperthermia

This study studies optimal design of focused antenna arrays for microwave-induced hyperthermia. The phases and amplitudes of the driving signals of array elements are determined by optimising the power transmission efficiency of the system consisting of the transmitting antenna array, a receiving antenna located in the target area, and an equivalent phantom representative of human tissues. On the basis of the proposed technique, a 4 × 2 focused patch array is designed to operate on a fat-mimicking phantom with working frequency at 433 MHz. The measured patterns for specific absorption rate indicate that the energy is focused in the desired spot and are in close agreement with simulations, which validate the optimisation method in a medium with low permittivity and low loss. A 4 × 3 focused patch array operating on a human body phantom with same working frequency is then designed, in which an air space and two additional dielectric layers have been introduced between the planar array and the body-mimicking phantom for impedance matching. A good focal performance at desired spot is also achieved, and the simulated and measured specific absorption rate patterns agree very well. This demonstrates the validity of the proposed design method in a medium with high permittivity and high loss.

[1]  Guo-Min Yang,et al.  Optimal Design of an Antenna Array for Energy Harvesting , 2013, IEEE Antennas and Wireless Propagation Letters.

[2]  W. Graham.  Analysis and synthesis of axial field patterns of focused apertures , 1983 .

[3]  J. Mead,et al.  A Near Field Focused Microstrip Array for a Radiometric Temperature Sensor , 2007, IEEE Transactions on Antennas and Propagation.

[4]  J. van der Zee,et al.  The Kadota Fund International Forum 2004–Clinical group consensus* , 2008, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[5]  S. Usman,et al.  Design, simulation and experimental study of near-field beam forming techniques using conformal waveguide arrays , 2010 .

[6]  S. Karimkashi,et al.  Focused Microstrip Array Antenna Using a Dolph-Chebyshev Near-Field Design , 2009, IEEE Transactions on Antennas and Propagation.

[7]  A. Garetsos,et al.  Development and Laboratory Testing of a Noninvasive Intracranial Focused Hyperthermia System , 2008, IEEE Transactions on Microwave Theory and Techniques.

[8]  Carey M. Rappaport,et al.  FDTD verification of deep-set brain tumor hyperthermia using a spherical microwave source distribution , 1996 .

[9]  A. G. Williamson,et al.  Antenna array with beam focused in near-field zone , 2003 .

[10]  Javad Nourinia,et al.  Near-Field Focused Array Microstrip Planar Antenna for Medical Applications , 2014, IEEE Antennas and Wireless Propagation Letters.

[11]  G. Borgiotti.  Maximum power transfer between two planar apertures in the Fresnel zone , 1966 .

[12]  James C. Lin,et al.  Computer simulation and experimental studies of SAR distributions of interstitial arrays of sleeved-slot microwave antennas for hyperthermia treatment of brain tumors , 2000 .

[13]  P. Fessenden,et al.  Body conformable 915 MHz microstrip array applicators for large surface area hyperthermia , 1992, IEEE Transactions on Biomedical Engineering.

[14]  Guo-Min Yang,et al.  A new design of focused antenna arrays , 2014 .

[15]  Wen Geyi,et al.  Optimal Design of Focused Antenna Arrays , 2014, IEEE Transactions on Antennas and Propagation.

[16]  A. Kay,et al.  Near-field gain of aperture antennas , 1960 .

[17]  Margarethus M. Paulides,et al.  A Patch Antenna Design for Application in a Phased-Array Head and Neck Hyperthermia Applicator , 2007, IEEE Transactions on Biomedical Engineering.

[18]  R. Knoechel.  Capabilities of Multiapplicator Systems for Focussed Hyperthermia , 1983 .

[19]  Hao Ling,et al.  Experimental Investigation of a Retro-Focusing Microwave Hyperthermia Applicator: Conjugate-Field Matching Scheme , 1986 .

[20]  Richard L. Magin,et al.  Focused Array Hyperthermia Applicator: Theory and Experiment , 1983, IEEE Transactions on Biomedical Engineering.

[21]  J. van der Zee,et al.  Characterization of the SAR-distribution of the Sigma-60 applicator for regional hyperthermia using a Schottky diode sheet , 2003, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[22]  F. Schwering,et al.  On the guided propagation of electromagnetic wave beams , 1961 .

[23]  Paul F. Turner,et al.  Regional Hyperthermia with an Annular Phased Array , 1984, IEEE Transactions on Biomedical Engineering.

[24]  E. Madsen,et al.  Tissue-mimicking phantom materials for narrowband and ultrawideband microwave applications , 2005, Physics in medicine and biology.

[25]  Zhi Ning Chen,et al.  In-silico hyperthermia performance of a near-field patch antenna at various positions on a human body model , 2011 .

[26]  J. Sherman.  Properties of focused apertures in the fresnel region , 1962 .

[27]  Gang Wang,et al.  Conformal Hyperthermia of Superficial Tumor With Left-Handed Metamaterial Lens Applicator , 2012, IEEE Transactions on Biomedical Engineering.

[28]  H.-T Chou,et al.  A Focused Planar Microstrip Array for 2.4 GHz RFID Readers , 2010, IEEE Transactions on Antennas and Propagation.

[29]  William C. Brown,et al.  Beamed microwave power transmission and its application to space , 1992 .

[30]  P. Stauffer,et al.  Radiation patterns of dual concentric conductor microstrip antennas for superficial hyperthermia , 1998, IEEE Transactions on Biomedical Engineering.

[31]  Paolo Nepa,et al.  Design of a Near-Field Focused Reflectarray Antenna for 2.4 GHz RFID Reader Applications , 2011, IEEE Transactions on Antennas and Propagation.

[32]  Thomas P. Minka,et al.  Gates , 2008, NIPS.

[33]  R B Roemer,et al.  Engineering aspects of hyperthermia therapy. , 1999, Annual review of biomedical engineering.

[34]  Andrew G. Webb,et al.  Optimization of electromagnetic phased-arrays for hyperthermia via magnetic resonance temperature estimation , 2002, IEEE Transactions on Biomedical Engineering.

[35]  F. Bardati,et al.  SAR optimization in a phased array radiofrequency hyperthermia system , 1995, IEEE Transactions on Biomedical Engineering.

[36]  Mark Dewhirst,et al.  A heterogeneous human tissue mimicking phantom for RF heating and MRI thermal monitoring verification , 2012, Physics in medicine and biology.

[37]  Allan G. Williamson,et al.  Microstrip Antenna Array With a Beam Focused in the Near-Field Zone for Application in Noncontact Microwave Industrial Inspection , 2007, IEEE Transactions on Instrumentation and Measurement.

[38]  A.J. Fenn,et al.  Experimental investigation of an adaptive feedback algorithm for hot spot reduction in radio-frequency phased-array hyperthermia , 1996, IEEE Transactions on Biomedical Engineering.

[39]  B. D. Veen,et al.  A computational study of ultra-wideband versus narrowband microwave hyperthermia for breast cancer treatment , 2006, IEEE transactions on microwave theory and techniques.

[40]  F. Gibbs,et al.  Regional Hyperthermia with an Annular Phased Array in the Experimental Treatment of Cancer: Report of Work in Progress with a Technical Emphasis , 1984, IEEE Transactions on Biomedical Engineering.