A new type of human papillomavirus associated with oral focal epithelial hyperplasia.

Lesions from 10 patients suffering from focal epithelial hyperplasia (FEH) of the oral mucosa, including those of 4 Greenlandic Eskimos, were investigated for the presence of human papillomavirus (HPV) DNA sequences by blot hybridization experiments. Two distinct HPVs were detected in the DNA extracted from these lesions, and their genomes were molecularly cloned and characterized. One of these HPVs, detected in 4 patients, was found to be identical with HPV13, whose association with FEH was already known. The other one, detected in 6 patients, was only weakly related to HPV13 and to the other HPVs associated with lesions of the mucous membranes, and constituted a new HPV type, tentatively named HPV32. Lesions from other types of oral papillomas, obtained from 14 additional patients, were also analyzed. Human papillomavirus DNA sequences were detected in the DNA preparations extracted from 5 specimens: HPV6 DNA in a condyloma and in a papilloma, 2 as yet uncharacterized HPV DNAs in 2 papillomas, and HPV32 DNA in a papilloma which showed histologic similarities to FEH. Thus, it seems likely that FEH of the oral mucosa is a disease associated with 2 specific HPVs--HPV13 and HPV32.

[1]  G. Temple,et al.  Cloning and characterization of the DNA of a new human papillomavirus from a woman with dysplasia of the uterine cervix , 1986, Journal of virology.

[2]  M. Campo,et al.  Molecular cloning and characterization of human papillomavirus type 7 DNA. , 1986, Virology.

[3]  M. Kawashima,et al.  Characterization of a new type of human papillomavirus found in a lesion of Bowen's disease of the skin , 1986, Journal of virology.

[4]  H. Hausen,et al.  Molecular cloning and characterization of the dna of a new human papillomavirus (hpv 30) from a laryngeal carcinoma , 1986, International journal of cancer.

[5]  G. Orth.  Epidermodysplasia verruciformis: a model for understanding the oncogenicity of human papillomaviruses. , 1986, Ciba Foundation symposium.

[6]  H. Kashima,et al.  Identification of genital tract papillomaviruses HPV‐6 and HPV‐16 in warts of the oral cavity , 1985, Journal of medical virology.

[7]  E. de Villiers,et al.  Papillomavirus DNA in human tongue carcinomas , 1985, International journal of cancer.

[8]  G. Orth,et al.  Cutaneous warts. Clinical, histologic, and virologic correlations. , 1985, Clinics in dermatology.

[9]  D. Lowy,et al.  X-linked inheritance of epidermodysplasia verruciformis. Genetic and virologic studies of a kindred. , 1985, Archives of dermatology.

[10]  L. Gissmann,et al.  The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumours. , 1985, The Journal of general virology.

[11]  J. Becker,et al.  Analysis of oral papillomas, leukoplakias, and invasive carcinomas for human papillomavirus type related DNA. , 1985, The Journal of investigative dermatology.

[12]  H. Pfister,et al.  Molecular cloning and characterization of the DNAs of human papillomaviruses 19, 20, and 25 from a patient with epidermodysplasia verruciformis , 1984, Journal of virology.

[13]  G. Orth,et al.  Molecular cloning and characterization of the genomes of nine newly recognized human papillomavirus types associated with epidermodysplasia verruciformis , 1984, Journal of virology.

[14]  Yvonne De Souza,et al.  ORAL "HAIRY" LEUCOPLAKIA IN MALE HOMOSEXUALS: EVIDENCE OF ASSOCIATION WITH BOTH PAPILLOMAVIRUS AND A HERPES-GROUP VIRUS , 1984, The Lancet.

[15]  S. Syrjänen,et al.  Human papilloma virus (HPV) antigens and local immunologic reactivity in oral squamous cell tumors and hyperplasias. , 1984, Scandinavian journal of dental research.

[16]  H. Hausen,et al.  A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer. , 1984, The EMBO journal.

[17]  A. Faras,et al.  Molecular cloning and characterization of a unique type of human papillomavirus from an immune deficient patient. , 1984, The Journal of investigative dermatology.

[18]  M. Dürst,et al.  DNA sequence and genome organization of genital human papillomavirus type 6b. , 1983, The EMBO journal.

[19]  G. Orth,et al.  Human papillomaviruses associated with epidermodysplasia verruciformis. II. Molecular cloning and biochemical characterization of human papillomavirus 3a, 8, 10, and 12 genomes , 1983, Journal of virology.

[20]  G. Orth,et al.  DETECTION OF HUMAN PAPILLOMAVIRUS TYPE 5 DNA IN SKIN CANCERS OF AN IMMUNOSUPPRESSED RENAL ALLOGRAFT RECIPIENT , 1983, The Lancet.

[21]  H. Pfister,et al.  Characterization of human papillomavirus type 13 from focal epithelial hyperplasia Heck lesions , 1983, Journal of virology.

[22]  L. Gissmann,et al.  A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[23]  F. Pass,et al.  Characterization of two HPV-3 related papillomaviruses from common warts that are distinct clinically from flat warts or epidermodysplasia verruciformis. , 1983, The Journal of investigative dermatology.

[24]  V. Diehl,et al.  Molecular cloning and characterization of human papilloma virus DNA derived from a laryngeal papilloma , 1982, Journal of virology.

[25]  G. Orth,et al.  Biochemical characterization of two types of human papillomaviruses associated with epidermodysplasia verruciformis , 1982, Journal of virology.

[26]  M. Lutzner,et al.  Different papillomaviruses as the causes of oral warts. , 1982, Archives of dermatology.

[27]  W. Lancaster,et al.  Frequency and distribution of papillomavirus structural antigens in verrucae, multiple papillomas, and condylomata of the oral cavity. , 1982, The American journal of pathology.

[28]  E. de Villiers,et al.  Molecular cloning of viral DNA from human genital warts , 1981, Journal of virology.

[29]  M. Israel,et al.  Cloning of human papilloma virus genomic DNAs and analysis of homologous polynucleotide sequences , 1980, Journal of virology.

[30]  H. Pfister,et al.  Papilloma virus particles in a fibroma of the tongue. , 1980, Acta dermato-venereologica.

[31]  G. Orth,et al.  Characterization of a New Type of Human Papillomavirus That Causes Skin Warts , 1977, Journal of virology.

[32]  C. W. Wyk.  Focal epithelial hyperplasia of the mouth: recently discovered in South Africa , 1977, The British journal of dermatology.

[33]  H. Hausen,et al.  Human papilloma viruses (HPV): characterization of four different isolates. , 1977, Virology.

[34]  D. Hogness,et al.  Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[35]  E. Jellinek.  Letter: Multiple sclerosis and diet. , 1974, Lancet.

[36]  F. Prætorius-Clausen.  Geographical Aspects of Oral Focal Epithelial Hyperplasia , 1973 .

[37]  F. Praetorius-Clausen.  Rare oral viral disorders (molluscum contagiosum, localized keratoacanthoma, verrucae, condyloma acuminatum, and focal epithelial hyperplasia). , 1972, Oral surgery, oral medicine, and oral pathology.

[38]  F. Praetorius-Clausen,et al.  Papova virus-like particles in focal epithelial hyperplasia. , 1971, Scandinavian journal of dental research.

[39]  Ronald W. Davis,et al.  [31] Electron microscope heteroduplex methods for mapping regions of base sequence homology in nucleic acids , 1971 .

[40]  S ORAM,et al.  THE NURSE'S LOAD. , 1965, Lancet.

[41]  H. Stanley,et al.  FOCAL EPITHELIAL HYPERPLASIA: AN UNUSUAL ORAL MUCOSAL LESION FOUND IN INDIAN CHILDREN. , 1965, Oral surgery, oral medicine, and oral pathology.