Shape-Dependent Two-Photon Photoluminescence of Single Gold Nanoparticles

Gold (Au) nanoparticles that display strong two-photon photoluminescence (TPPL) are attractive contrast agents for noninvasive live cell/tissue imaging with deep penetration because of their excellent biocompatibility and low cytotoxicity. The TPPL properties of Au nanoparticles are strongly dependent on the particle shape. As chemically prepared nanoparticles are generally inhomogeneous, conventional ensemble-based TPPL measurements can only give averaged results of particles of different morphologies. Single-particle spectroscopy can avoid the complication induced by the sample inhomogeneity in ensemble measurements and help to establish the morphology–property relationship. Here we have investigated the scattering spectra and TPPL properties of Au nanoparticles of different shapes on the single particle level and explored their potential applications in cancer cell imaging. Au nanoparticles of five different shapes (nanospheres, nanocubes, nanotriangles, nanorods, and nanobranches) with similar dimensi...

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