Can Intestinal Fatty Acid Binding Protein (I-FABP) Be A Marker in the Diagnosis of Abdominal Pathology?

SUMMARY Objectives Biochemical markers play an important role in the early diagnosis of abdominal pain. This study aimed to investigate the diagnostic value of intestinal type fatty acid binding protein (I-FABP) in patients with abdominal pathology. Methods This prospective and descriptive study was performed at the University Hospital Emergency Department. Serum I-FABP levels of patients presenting with acute abdominal pain were measured at time of admission and were compared with those of healthy individuals. Results The mean I-FABP level of the 171 patients enrolled in this study was 170.1±543.4 pg/ml, while that of a healthy control group was 61.4±47.4 pg/ml. Although I-FABP levels were higher in the patient group, this difference was not statistically significant (p>0.05). However, I-FABP levels of patients with mesenteric ischemia and intra-abdominal mass were significantly higher than those of healthy individuals (p≤0.05). Conclusions I-FABP levels that are evaluated at time of admission in patients presenting with abdominal pain to the emergency department are significantly higher in patients with mesenteric ischemia and intra-abdominal mass than are those of healthy individuals.

[1]  C. Wiener.  Harrison's principles of internal medicine , 2013 .

[2]  M. Prins,et al.  Circulating Intestinal Fatty Acid-Binding Protein as an Early Marker of Intestinal Necrosis After Aortic Surgery: A Prospective Observational Cohort Study , 2012, Annals of surgery.

[3]  S. Acosta,et al.  Current status on plasma biomarkers for acute mesenteric ischemia , 2012, Journal of Thrombosis and Thrombolysis.

[4]  I. Marzi,et al.  Intestinal-FABP and liver-FABP: Novel markers for severe abdominal injury. , 2010, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[5]  H. Lippert,et al.  [The acute (surgical) abdomen - epidemiology, diagnosis and general principles of management]. , 2010, Zeitschrift fur Gastroenterologie.

[6]  M. Colgin,et al.  S100A8/A9: a potential new diagnostic aid for acute appendicitis. , 2010, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[7]  Alper Akcan,et al.  Travma dışı akut karınlı hastaların tanısında D-dimer testinin değeri , 2010 .

[8]  Namik Yilmaz,et al.  The value of D-dimer test in the diagnosis of patients with nontraumatic acute abdomen. , 2010, Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES.

[9]  G. Kristiansen,et al.  Brain-type and liver-type fatty acid-binding proteins: new tumor markers for renal cancer? , 2009, BMC Cancer.

[10]  M. Topbaş,et al.  Time-dependent variations in ischemia-modified albumin levels in mesenteric ischemia. , 2009, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[11]  J. Windsor,et al.  Systematic Review and Pooled Estimates for the Diagnostic Accuracy of Serological Markers for Intestinal Ischemia , 2009, World Journal of Surgery.

[12]  L. Holmdahl,et al.  A local imbalance between MMP and TIMP may have an implication on the severity and course of appendicitis , 2008, International Journal of Colorectal Disease.

[13]  T. Ono,et al.  Intestinal fatty acid-binding protein as a sensitive marker of intestinal ischemia , 1992, Digestive Diseases and Sciences.

[14]  T. Niewold,et al.  Plasma intestinal fatty acid binding protein (I-FABP) concentrations increase following intestinal ischemia in pigs. , 2004, Research in veterinary science.

[15]  M. Björck,et al.  D‐dimer testing in patients with suspected acute thromboembolic occlusion of the superior mesenteric artery , 2004, The British journal of surgery.

[16]  S. Acosta,et al.  Preliminary study of D‐dimer as a possible marker of acute bowel ischaemia , 2001, The British journal of surgery.

[17]  S. O’Neill,et al.  Plasma concentrations of glutathione S‐transferase isoenzyme are raised in patients with intestinal ischaemia , 1999, The British journal of surgery.

[18]  P. Wollan,et al.  Emergency department evaluation of geriatric patients with acute cholecystitis. , 1997, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[19]  G. J. van der Vusse,et al.  Cellular fatty acid-binding proteins: their function and physiological significance. , 1996, Progress in lipid research.

[20]  T. Ono,et al.  Intestinal fatty acid-binding protein is a useful diagnostic marker for mesenteric infarction in humans. , 1996, Gastroenterology.

[21]  T. Ono,et al.  Intestinal fatty acid binding protein is available for diagnosis of intestinal ischaemia: immunochemical analysis of two patients with ischaemic intestinal diseases. , 1995, Gut.

[22]  Sami Ahmad.  Oxidative Stress and Antioxidant Defenses in Biology , 1995, Springer US.

[23]  M. Grisham,et al.  Pathophysiology and Reactive Oxygen Metabolites , 1995 .

[24]  M. E. Lores,et al.  The significance of elevation of serum phosphate levels in experimental intestinal ischemia. , 1981, Surgery, gynecology & obstetrics.

[25]  R. Ockner,et al.  Fatty acid-binding protein in small intestine. Identification, isolation, and evidence for its role in cellular fatty acid transport. , 1974, The Journal of clinical investigation.