论文信息 - A change in the physical state of a nonequilibrium blood plasma protein film in patients with carcinoma

A change in the physical state of a nonequilibrium blood plasma protein film in patients with carcinoma

Pronounced changes in the physical phase and in the phase transition dynamics of proteins in drying blood plasma are observed. The morphologies (topologies) of these nonequilibrium films in donors and in patients with various types of metastatic carcinoma qualitatively differ by the process of protein film self-assembly and by symmetry type. New types of defects and solid crystals appear, liquid crystals persist for a long time, etc. The microscopic examination of the drying protein plasma topology can be used for diagnosing metastatic carcinoma.

E. Rapis | E. Rapis

[1] D. S. Coffey. Reply to “Chaos in cancer?” , 1998, Nature Medicine.

[2] B. Alberts,et al. Purification of a multiprotein complex containing centrosomal proteins from the Drosophila embryo by chromatography with low-affinity polyclonal antibodies. , 1992, Molecular biology of the cell.

[3] E. Jones,et al. Thrombosis and coagulation abnormalities associated with cancer. , 1994, Annals of clinical and laboratory science.

[4] D. Ferrigno,et al. Haemostatic abnormalities in lung cancer: prognostic implications. , 1997, European journal of cancer.

[5] J Brickmann,et al. Self similarity of protein surfaces. , 1992, Biophysical journal.

[6] P. Wolynes,et al. The physics of protein folding , 1999 .

[7] E. J. Ambrose,et al. Microelectrophoresis of Normal and Transformed Clones of Hamster Kidney Fibroblasts , 1964, Nature.

[8] Johannes Helder,et al. Enzymology: Degradation of plant cell walls by a nematode , 2000, Nature.