Carotid artery stiffness and hemodynamic pulsatility during cognitive engagement in healthy adults: a pilot investigation.

BACKGROUND The matching of vascular supply to neuronal metabolic demand during cognitive engagement is known as neurovascular coupling (NVC). Arterial stiffness is a prominent determinant of pulsatility in the systemic circulation and may thus indirectly impact NVC. In this pilot investigation, we explored changes in carotid artery stiffness and cerebrovascular hemodynamic pulsatiltiy during cognitive engagement in healthy adults. METHODS Twenty-seven adults (age 39 ± 3 years, BMI 24 ± 1 kg/m(2)) underwent Doppler ultrasonography of the common carotid artery (CCA) combined with applanation tonometry to derive (i) CCA elastic modulus (Ep) and β-stiffness index; (ii) CCA flow pulsatility index (PI); (iii) CCA pulse pressure, (iv) CCA augmentation index (AIx). Cerebral PI was assessed using transcranial Doppler at the middle cerebral artery (MCA). All measures were made at rest and during an incongruent Stroop task. RESULTS CCA PI was reduced (1.75 ± 0.06 to 1.57 ± 0.06, P < 0.05) while MCA PI was unchanged (0.75 ± 0.02 to 0.75 ± 0.02, P > 0.05) during Stroop. Brachial pulse pressure increased during Stroop (43 ± 1 to 46 ± 1 mm Hg, P < 0.05) while CCA pulse pressure was unchanged (36 ± 1 to 35 ± 1 mm Hg, P > 0.05). Similarly, CCA Ep (54.5 ± 5.5 to 53.8 ± 4.9 kPa, P > 0.05) and β-stiffness index (4.4 ± 0.4 to 4.2 ± 0.3 aU, P > 0.05) were unchanged. CCA AIx increased (1 ± 4 to 13 ± 4%, P < 0.05). CONCLUSION Carotid pressure pulsatility is unaltered while carotid flow pulsatility is reduced during cognitive engagement. Carotid artery stiffness does not change suggesting that factors other than the dynamic elastic properties of the CCA buffer cerebrovascular hemodynamic pulsatility during cognitive engagement.

[1]  K. Heffernan,et al.  The relationship between carotid blood pressure reactivity to mental stress and carotid intima-media thickness. , 2014, Atherosclerosis.

[2]  A. Wykrętowicz,et al.  Gray matter volume in relation to cardio-vascular stiffness , 2014, Journal of the Neurological Sciences.

[3]  L. Kuller,et al.  Arterial stiffness and β-amyloid progression in nondemented elderly adults. , 2014, JAMA neurology.

[4]  Benjamin S. Aribisala,et al.  Blood Pressure, Internal Carotid Artery Flow Parameters, and Age-Related White Matter Hyperintensities , 2014, Hypertension.

[5]  D. Attwell,et al.  Capillary pericytes regulate cerebral blood flow in health and disease , 2014, Nature.

[6]  S. Girdler,et al.  Mechanisms underlying hemodynamic and neuroendocrine stress reactivity at different phases of the menstrual cycle. , 2014, Psychophysiology.

[7]  Rong Zhang,et al.  Cerebral Hemodynamics in Normal Aging: Central Artery Stiffness, Wave Reflection, and Pressure Pulsatility , 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[8]  Joseph A Fisher,et al.  Integrative regulation of human brain blood flow , 2014, The Journal of physiology.

[9]  Eric E. Smith,et al.  Effects of aging on the association between cerebrovascular responses to visual stimulation, hypercapnia and arterial stiffness , 2014, Front. Physiol..

[10]  A. Wåhlin,et al.  Intracranial pulsatility is associated with regional brain volume in elderly individuals , 2014, Neurobiology of Aging.

[11]  Arthur F. Kramer,et al.  Neurovascular coupling in normal aging: A combined optical, ERP and fMRI study , 2014, NeuroImage.

[12]  J. Sugawara,et al.  Lack of changes in carotid artery compliance with systemic nitric oxide synthase inhibition , 2014, Journal of Human Hypertension.

[13]  S. Strath,et al.  Relative Importance of Step Count, Intensity, and Duration on Physical Activity's Impact on Vascular Structure and Function in Previously Sedentary Older Adults , 2014, Journal of the American Heart Association.

[14]  E. Connolly,et al.  Middle cerebral artery pulsatility index and cognitive improvement after carotid endarterectomy for symptomatic stenosis. , 2014, Journal of neurosurgery.

[15]  F. Karayanidis,et al.  Early detection of microstructural white matter changes associated with arterial pulsatility , 2013, Front. Hum. Neurosci..

[16]  K. Heffernan,et al.  Hemodynamic Correlates of Late Systolic Flow Velocity Augmentation in the Carotid Artery , 2013, International journal of hypertension.

[17]  Christopher J. Marley,et al.  Elevated Aerobic Fitness Sustained Throughout the Adult Lifespan Is Associated With Improved Cerebral Hemodynamics , 2013, Stroke.

[18]  D. Levy,et al.  Relations of arterial stiffness and endothelial function to brain aging in the community , 2013, Neurology.

[19]  B. Mazoyer,et al.  Large-vessel correlates of cerebral small-vessel disease , 2013, Neurology.

[20]  Vijay K. Venkatraman,et al.  Aortic Pulse Wave Velocity Predicts Focal White Matter Hyperintensities in a Biracial Cohort of Older Adults , 2013, Hypertension.

[21]  V. Mok,et al.  Evaluation of Age‐Related White Matter Changes Using Transcranial Doppler Ultrasonography , 2011, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[22]  Wilhelm Kuker,et al.  Increased Cerebral Arterial Pulsatility in Patients With Leukoaraiosis: Arterial Stiffness Enhances Transmission of Aortic Pulsatility , 2012, Stroke.

[23]  M. Arfan Ikram,et al.  Arterial Stiffness and Cerebral Small Vessel Disease: The Rotterdam Scan Study , 2012 .

[24]  J. Jennings,et al.  Test-retest reliability of an fMRI paradigm for studies of cardiovascular reactivity. , 2012, Psychophysiology.

[25]  Ya Miao,et al.  Common Carotid Flow Velocity is Associated with Cognition in Older Adults , 2012, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[26]  E. Bouskela,et al.  Early postmenopausal women with cardiovascular risk factors improve microvascular dysfunction after acute estradiol administration , 2012, Menopause.

[27]  Yan Li,et al.  Blood flow pattern in the middle cerebral artery in relation to indices of arterial stiffness in the systemic circulation. , 2012, American journal of hypertension.

[28]  Vanessa Sluming,et al.  Calibrated fMRI during a cognitive Stroop task reveals reduced metabolic response with increasing age , 2012, NeuroImage.

[29]  V. Gudnason,et al.  Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility--Reykjavik study. , 2011, Brain : a journal of neurology.

[30]  A. Haley,et al.  Association between central elastic artery stiffness and cerebral perfusion in deep subcortical gray and white matter. , 2011, American journal of hypertension.

[31]  S. Black,et al.  Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association , 2011, Stroke.

[32]  Y. C. Tzeng,et al.  Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function , 2011, Journal of Neuroscience Methods.

[33]  I. Hajjar,et al.  The relationship between blood pressure and cognitive function , 2010, Nature Reviews Cardiology.

[34]  L. Panych,et al.  Brain Blood Flow and Velocity , 2010, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[35]  D. Madden,et al.  Effects of Adult Age and Blood Pressure on Executive Function and Speed of Processing , 2010, Experimental aging research.

[36]  Philip Chowienczyk,et al.  Dissociation of Aortic Pulse Wave Velocity With Risk Factors for Cardiovascular Disease Other Than Hypertension: A Systematic Review , 2009, Hypertension.

[37]  A. Zonderman,et al.  Blood pressure reactivity and cognitive function in the Baltimore Longitudinal Study of Aging. , 2009, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[38]  T. Naqvi,et al.  Cerebrovascular mental stress reactivity is impaired in hypertension , 2009, Cardiovascular ultrasound.

[39]  T. Hatta,et al.  Menstrual Cycle Phase Effects on Memory and Stroop Task Performance , 2009, Archives of sexual behavior.

[40]  T. Grodzicki,et al.  Is blood flow in the middle cerebral artery determined by systemic arterial stiffness? , 2009, Blood pressure.

[41]  Farzaneh A. Sorond,et al.  Cerebral blood flow regulation during cognitive tasks: Effects of healthy aging , 2008, Cortex.

[42]  O. Witte,et al.  Effects of physiological aging and cerebrovascular risk factors on the hemodynamic response to brain activation: A functional transcranial doppler study , 2006, Clinical Neurophysiology.

[43]  Alberto Boveris,et al.  Oxygen delivery to the tissues and mitochondrial respiration. , 2007, Frontiers in bioscience : a journal and virtual library.

[44]  Christodoulos Stefanadis,et al.  Acute Mental Stress Has a Prolonged Unfavorable Effect on Arterial Stiffness and Wave Reflections , 2006, Psychosomatic medicine.

[45]  J. Sugawara,et al.  Variations in carotid arterial compliance during the menstrual cycle in young women , 2006, Experimental physiology.

[46]  Jelle Jolles,et al.  The Stroop Color-Word Test , 2006, Assessment.

[47]  S. Waldstein,et al.  Stress-induced blood pressure reactivity and cognitive function , 2005, Neurology.

[48]  E. Siegel,et al.  Stress-Induced Blood Pressure Reactivity and Silent Cerebrovascular Disease , 2004, Stroke.

[49]  Guy Vingerhoets,et al.  Transcranial Doppler Ultrasonography Monitoring of Cerebral Hemodynamics During Performance of Cognitive Tasks: A Review , 2000, Neuropsychology Review.

[50]  A. Rosengren,et al.  Acute effects of transdermal estrogen on hemodynamic and vascular reactivity in elderly postmenopausal healthy women , 2003, Journal of hypertension.

[51]  T. Dalsgaard,et al.  Acute effects of tibolone on cerebral vascular reactivity in vitro , 2003, Climacteric : the journal of the International Menopause Society.

[52]  B. Rosengarten,et al.  Neurovascular Coupling Remains Unaffected During Normal Aging , 2003, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[53]  P. Luiten,et al.  Cerebral microvascular pathology in aging and Alzheimer's disease , 2001, Progress in Neurobiology.

[54]  J. Krejza,et al.  Effect of endogenous estrogen on blood flow through carotid arteries. , 2001, Stroke.

[55]  G. Vingerhoets,et al.  Lateralization of cerebral blood flow velocity changes during cognitive tasks. A simultaneous bilateral transcranial Doppler study. , 1999, Stroke.

[56]  M. Hennerici,et al.  Age and stimulus dependency of visually evoked cerebral blood flow responses. , 1999, Stroke.

[57]  Richard P. White,et al.  Nitric oxide synthase inhibition in humans reduces cerebral blood flow but not the hyperemic response to hypercapnia. , 1998, Stroke.

[58]  M. Joyner,et al.  Forearm sympathetic withdrawal and vasodilatation during mental stress in humans , 1997, The Journal of physiology.

[59]  S. Eggener,et al.  Nitric oxide contributes to the rise in forearm blood flow during mental stress in humans. , 1994, The Journal of physiology.

[60]  P. Boutouyrie,et al.  Sympathetic activation decreases medium-sized arterial compliance in humans. , 1994, The American journal of physiology.

[61]  W D Obrist,et al.  Age and regional cerebral blood flow at rest and during cognitive activity. , 1987, Archives of general psychiatry.