Synthetic lethal approaches to breast cancer therapy
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[1] J. Dungan. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial , 2011 .
[2] A. Ashworth,et al. A Marker of Homologous Recombination Predicts Pathologic Complete Response to Neoadjuvant Chemotherapy in Primary Breast Cancer , 2010, Clinical Cancer Research.
[3] K. Flaherty,et al. Inhibition of mutated, activated BRAF in metastatic melanoma. , 2010, The New England journal of medicine.
[4] B. Karlan,et al. Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[5] Mark Robson,et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial , 2010, The Lancet.
[6] A. Tutt,et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial , 2010, The Lancet.
[7] Yiyu Dong,et al. Synthetic lethality through combined Notch-epidermal growth factor receptor pathway inhibition in basal-like breast cancer. , 2010, Cancer research.
[8] Ricky A. Sharma,et al. Molecular and Cellular Pathobiology Cancer Research Poly ( ADP-Ribose ) Polymerase Is Hyperactivated in Homologous Recombination – Defective Cells , 2010 .
[9] M. Grace,et al. Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3 , 2010, Proceedings of the National Academy of Sciences.
[10] F. Bauzon,et al. Racing to block tumorigenesis after pRb loss: An innocuous point mutation wins with synthetic lethality , 2010, Cell cycle.
[11] C. Croce,et al. Roles of small RNAs in tumor formation. , 2010, Trends in molecular medicine.
[12] A. Oza,et al. Can we define tumors that will respond to PARP inhibitors? A phase II correlative study of olaparib in advanced serous ovarian cancer and triple-negative breast cancer. , 2010 .
[13] Jan Lubinski,et al. Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[14] A. Ashworth,et al. Biology-driven cancer drug development: back to the future , 2010, BMC Biology.
[15] Y. Drew,et al. Development of a Functional Assay for Homologous Recombination Status in Primary Cultures of Epithelial Ovarian Tumor and Correlation with Sensitivity to Poly(ADP-Ribose) Polymerase Inhibitors , 2010, Clinical Cancer Research.
[16] P. Deloukas,et al. Signatures of mutation and selection in the cancer genome , 2010, Nature.
[17] A. Brandes,et al. Trastuzumab and lapatinib beyond trastuzumab progression for metastatic breast cancer: strategies and pitfalls , 2010, Expert review of anticancer therapy.
[18] M. O’Connor,et al. ATM Deficiency Sensitizes Mantle Cell Lymphoma Cells to Poly(ADP-Ribose) Polymerase-1 Inhibitors , 2010, Molecular Cancer Therapeutics.
[19] Tom Royce,et al. A comprehensive catalogue of somatic mutations from a human cancer genome , 2010, Nature.
[20] Marcel J T Reinders,et al. Imaging , Diagnosis , Prognosis Clinical Cancer Research Integration of DNA Copy Number Alterations and Prognostic Gene Expression Signatures in Breast Cancer Patients , 2010 .
[21] Makiko Takahashi,et al. Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins , 2010, Breast Cancer Research.
[22] A. Ashworth,et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. , 2009, The New England journal of medicine.
[23] D. Patt,et al. Final Results of a Randomized Phase II Study Demonstrating Efficacy and Safety of BSI-201, a Poly (ADP-Ribose) Polymerase (PARP) Inhibitor, in Combination with Gemcitabine/Carboplatin (G/C) in Metastatic Triple Negative Breast Cancer (TNBC). , 2009 .
[24] N. Hynes,et al. Key signalling nodes in mammary gland development and cancer: Myc , 2009, Breast Cancer Research.
[25] K. Flaherty,et al. 6BA Early efficacy signal demonstrated in advanced melanoma in a phase I trial of the oncogenic BRAF-selective inhibitor PLX4032 , 2009 .
[26] Jung-Sik Kim,et al. Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors , 2009, EMBO molecular medicine.
[27] E. Brown,et al. Tissue regenerative delays and synthetic lethality in adult mice upon combined deletion of ATR and p53 , 2009, Nature Genetics.
[28] F. Couch,et al. Edinburgh Research Explorer Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma , 2022 .
[29] D. Geerts,et al. Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells , 2009, Proceedings of the National Academy of Sciences.
[30] T. Pandita,et al. Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair , 2009, Cell cycle.
[31] D. Patt,et al. Efficacy of BSI-201, a poly (ADP-ribose) polymerase-1 (PARP1) inhibitor, in combination with gemcitabine/carboplatin (G/C) in patients with metastatic triple-negative breast cancer (TNBC): Results of a randomized phase II trial. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[32] A. Tutt,et al. Phase II trial of the oral PARP inhibitor olaparib in BRCA-deficient advanced breast cancer. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[33] C. Palmieri,et al. A 2009 update on the treatment of patients with hormone receptor-positive breast cancer. , 2009, Clinical breast cancer.
[34] A. Ashworth,et al. Tiling Path Genomic Profiling of Grade 3 Invasive Ductal Breast Cancers , 2009, Clinical Cancer Research.
[35] M. Stockler,et al. Third consensus on medical treatment of metastatic breast cancer. , 2007, Annals of oncology : official journal of the European Society for Medical Oncology.
[36] P. Borst,et al. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs , 2008, Proceedings of the National Academy of Sciences.
[37] Y. Yin,et al. PTEN: a new guardian of the genome , 2008, Oncogene.
[38] S. Johnston,et al. Platinum-based chemotherapy in triple-negative breast cancer. , 2008, Annals of oncology : official journal of the European Society for Medical Oncology.
[39] Pier Paolo Pandolfi,et al. Tenets of PTEN Tumor Suppression , 2008, Cell.
[40] B. Karlan,et al. Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance. , 2008, Cancer research.
[41] Jorge S. Reis-Filho,et al. Resistance to therapy caused by intragenic deletion in BRCA2 , 2008, Nature.
[42] F. Couch,et al. Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers , 2008, Nature.
[43] A. Joe,et al. Oncogene addiction. , 2008, Cancer research.
[44] Sreenath V. Sharma,et al. Oncogene addiction: setting the stage for molecularly targeted cancer therapy. , 2007, Genes & development.
[45] N. Curtin,et al. PARP inhibitor development for systemic cancer targeting. , 2007, Anti-cancer agents in medicinal chemistry.
[46] E. Kritikou. Tumorigenesis: PTEN — a new guardian of the genome , 2007, Nature Reviews Cancer.
[47] Michael B Yaffe,et al. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. , 2007, Cancer cell.
[48] P. Pandolfi,et al. Essential Role for Nuclear PTEN in Maintaining Chromosomal Integrity , 2007, Cell.
[49] Ian Collins,et al. New approaches to molecular cancer therapeutics , 2006, Nature chemical biology.
[50] Robert Tibshirani,et al. Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene‐expression subtypes of breast cancer , 2006, Genes, chromosomes & cancer.
[51] J. Reis-Filho,et al. Basal-like breast cancer and the BRCA1 phenotype , 2006, Oncogene.
[52] Alan Ashworth,et al. Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. , 2006, Cancer research.
[53] W. Kaelin. The Concept of Synthetic Lethality in the Context of Anticancer Therapy , 2005, Nature Reviews Cancer.
[54] A. Ashworth,et al. BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of poly (ADP-ribose) polymerase: An issue of potency , 2005, Cancer biology & therapy.
[55] L. Symington. Focus on recombinational DNA repair , 2005, EMBO reports.
[56] Thomas Helleday,et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase , 2005, Nature.
[57] Alan Ashworth,et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy , 2005, Nature.
[58] A. Ashworth,et al. Exploiting the DNA repair defect in BRCA mutant cells in the design of new therapeutic strategies for cancer. , 2005, Cold Spring Harbor symposia on quantitative biology.
[59] M. Cronin,et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. , 2004, The New England journal of medicine.
[60] A. Ashworth,et al. Hallmarks of 'BRCAness' in sporadic cancers , 2004, Nature Reviews Cancer.
[61] G. de Murcia,et al. The PARP superfamily , 2004, BioEssays : news and reviews in molecular, cellular and developmental biology.
[62] Marc Nasoff,et al. Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway. , 2004, Cancer cell.
[63] M. McMillan. History revisited. , 2004, The Australian journal of rural health.
[64] Guan Chen,et al. Potentiation of the antitumor activity of cisplatin in mice by 3-aminobenzamide and nicotinamide , 2004, Cancer Chemotherapy and Pharmacology.
[65] R. Love,et al. Oophorectomy for breast cancer: history revisited. , 2002, Journal of the National Cancer Institute.
[66] I. Weinstein. Addiction to Oncogenes--the Achilles Heal of Cancer , 2002, Science.
[67] I. Smith,et al. The development and clinical use of trastuzumab (Herceptin). , 2002, Endocrine-related cancer.
[68] V. Heinemann. Gemcitabine plus cisplatin for the treatment of metastatic breast cancer. , 2002, Clinical breast cancer.
[69] Lyndsay N Harris,et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[70] B. Druker,et al. Perspectives on the development of a molecularly targeted agent. , 2002, Cancer cell.
[71] Y. Lu,et al. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). , 2001, Journal of the National Cancer Institute.
[72] D. Wickerham,et al. Findings from recent National Surgical Adjuvant Breast and Bowel Project adjuvant studies in stage I breast cancer. , 2001, Journal of the National Cancer Institute. Monographs.
[73] T. Helleday,et al. DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells. , 2001, Journal of molecular biology.
[74] C. Sawyers,et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. , 2001, The New England journal of medicine.
[75] Larry L. Constantine,et al. Back to the future , 2001, CACM.
[76] C. Eng,et al. PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death. , 1999, Cancer research.
[77] N. Robert,et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[78] L. Hartwell,et al. Integrating genetic approaches into the discovery of anticancer drugs. , 1997, Science.
[79] M. Stratton. Pathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases , 1997, The Lancet.
[80] Alfred A. Boyd,et al. Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2 , 1996, Nature Genetics.
[81] Kenneth Offit,et al. The carrier frequency of the BRCA2 6174delT mutation among Ashkenazi Jewish individuals is approximately 1% , 1996, Nature Genetics.
[82] Q. Pan,et al. The potentiation of the antitumor activity but not toxicity of bleomycin by 3-aminobenzamide. , 1989, The Journal of antibiotics.
[83] B. Groner,et al. Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading. , 1988, Cancer research.
[84] Susan M. Watanabe,et al. An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity , 1984, Cell.
[85] J. Lucchesi. Synthetic lethality and semi-lethality among functionally related mutants of Drosophila melanfgaster. , 1968, Genetics.
[86] T. Dobzhansky,et al. Genetics of Natural Populations. Xiii. Recombination and Variability in Populations of Drosophila Pseudoobscura. , 1946, Genetics.