Microfinite Element Modeling for Evaluating Polymer Scaffolds Architecture and their Mechanical Properties from microComputed Tomography

Angel Alberich-Bayarri1, Manuel Salmeron Sanchez2 M. Angeles Perez3 and David Moratal2 1 Department of Radiology, Hospital Quiron Valencia, Valencia, Spain. 2 Center for Biomaterials and Tissue Engineering, Universitat Politecnica de Valencia, Valencia, Spain. 3 Group of Structural Mechanics and Materials Modeling, Instituto de Investigacion en Ingenieria de Aragon, Universidad de Zaragoza, Zaragoza, Spain.

[1]  N. Passuti,et al.  Long-term bone response to particulate injectable ceramic. , 1998, Journal of biomedical materials research.

[2]  Dietmar W Hutmacher,et al.  A comparison of micro CT with other techniques used in the characterization of scaffolds. , 2006, Biomaterials.

[3]  Kevin E. Healy,et al.  A novel method to fabricate bioabsorbable scaffolds , 1995 .

[4]  C A van Blitterswijk,et al.  3D fiber-deposited scaffolds for tissue engineering: influence of pores geometry and architecture on dynamic mechanical properties. , 2006, Biomaterials.

[5]  R Langer,et al.  Laminated three-dimensional biodegradable foams for use in tissue engineering. , 1993, Biomaterials.

[6]  D J Mooney,et al.  Open pore biodegradable matrices formed with gas foaming. , 1998, Journal of biomedical materials research.

[7]  B. Ratner,et al.  Hydrophilic-hydrophobic copolymers as cell substrates: Effect on 3T3 cell growth rates , 1985 .

[8]  Antonios G. Mikos,et al.  Biodegradable polymer scaffolds to regenerate organs , 1995 .

[9]  C. Rau,et al.  Noninvasive bone replacement with a new injectable calcium phosphate biomaterial. , 2003, Journal of biomedical materials research. Part A.

[10]  J. R. Parsons,et al.  Resorbable materials and composites. New concepts in orthopedic biomaterials. , 1985, Orthopedics.

[11]  P. Ma,et al.  Poly(alpha-hydroxyl acids)/hydroxyapatite porous composites for bone-tissue engineering. I. Preparation and morphology. , 1999, Journal of biomedical materials research.

[12]  N. Otsu.  A threshold selection method from gray level histograms , 1979 .

[13]  R Langer,et al.  Chondrogenesis in a cell-polymer-bioreactor system. , 1998, Experimental cell research.

[14]  M. Barbosa,et al.  Engineering endochondral bone: in vivo studies. , 2009, Tissue engineering. Part A.

[15]  C. Geffre,et al.  A novel biomimetic polymer scaffold design enhances bone ingrowth. , 2009, Journal of biomedical materials research. Part A.

[16]  Jia-cong Shen,et al.  Fabrication of porous collagen/chitosan scaffolds with controlling microstructure for dermal equivalent , 2003 .

[17]  David Moratal,et al.  Microcomputed tomography and microfinite element modeling for evaluating polymer scaffolds architecture and their mechanical properties. , 2009, Journal of biomedical materials research. Part B, Applied biomaterials.

[18]  José Manuel García-Aznar,et al.  Polymer scaffolds with interconnected spherical pores and controlled architecture for tissue engineering: fabrication, mechanical properties, and finite element modeling. , 2007, Journal of biomedical materials research. Part B, Applied biomaterials.

[19]  William E. Lorensen,et al.  Marching cubes: A high resolution 3D surface construction algorithm , 1987, SIGGRAPH.

[20]  S. Goldstein,et al.  Application of homogenization theory to the study of trabecular bone mechanics. , 1991, Journal of biomechanics.

[21]  Josep A Planell,et al.  Micro-finite element models of bone tissue-engineering scaffolds. , 2006, Biomaterials.

[22]  N. Kikuchi,et al.  A comparison of homogenization and standard mechanics analyses for periodic porous composites , 1992 .

[23]  Ralph Müller,et al.  Nondestructive micro-computed tomography for biological imaging and quantification of scaffold-bone interaction in vivo. , 2007, Biomaterials.

[24]  David Moratal,et al.  In vivo trabecular bone morphologic and mechanical relationship using high-resolution 3-T MRI. , 2008, AJR. American journal of roentgenology.

[25]  D. Hutmacher,et al.  Scaffolds in tissue engineering bone and cartilage. , 2000, Biomaterials.

[26]  K. Leong,et al.  The design of scaffolds for use in tissue engineering. Part I. Traditional factors. , 2001, Tissue engineering.

[27]  O. C. Zienkiewicz,et al.  The Finite Element Method: Its Basis and Fundamentals , 2005 .

[28]  I Naert,et al.  Individualised, micro CT-based finite element modelling as a tool for biomechanical analysis related to tissue engineering of bone. , 2004, Biomaterials.

[29]  D. Moratal,et al.  Volume Mesh Generation and Finite Element Analysis of Trabecular Bone Magnetic Resonance Images , 2007, 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[30]  H. Hajiali,et al.  Preparation of a novel biodegradable nanocomposite scaffold based on poly (3-hydroxybutyrate)/bioglass nanoparticles for bone tissue engineering , 2010, Journal of materials science. Materials in medicine.

[31]  O. Trentz,et al.  Cancellous allograft versus autologous bone grafting for repair of comminuted distal radius fractures: a prospective, randomized trial. , 2006, The Journal of trauma.

[32]  Changyou Gao,et al.  Microstructure and mechanical properties of poly(L‐lactide) scaffolds fabricated by gelatin particle leaching method , 2005 .