CHOROIDAL NEOVASCULARIZATION IN AGE-RELATED MACULAR DEGENERATION—WHAT IS THE CAUSE?

After completion of this article, the reader will be able to: 1) describe, define, and discuss various theories concerning the pathogenesis of choroidal neovascularization in age-related macular degeneration, 2) identify and classify risk factors for the development of age-related macular degeneration, 3) outline and specify how stimuli for neovascularization may arise, and 4) critique proposed etiologic theories.

[1]  G. Wolf.  Lipofuscin, the age pigment. , 2009, Nutrition reviews.

[2]  W R Green,et al.  CLINICOPATHOLOGIC CORRELATION OF DRUSEN AND RETINAL PIGMENT EPITHELIAL ABNORMALITIES IN AGE-RELATED MACULAR DEGENERATION , 2005, Retina.

[3]  K. Csaky,et al.  Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factor , 2003, Journal of Cell Science.

[4]  J. Hoeijmakers,et al.  Aging and Genome Maintenance: Lessons from the Mouse? , 2003, Science.

[5]  Richard F Spaide,et al.  Fundus autofluorescence and age-related macular degeneration. , 2003, Ophthalmology.

[6]  P. Parsons,et al.  Influence of ageing, heat shock treatment and in vivo total antioxidant status on gene-expression profile and protein synthesis in human peripheral lymphocytes , 2003, Mechanisms of Ageing and Development.

[7]  W. W. Adams,et al.  Antioxidants in Photosynthesis and Human Nutrition , 2002, Science.

[8]  D. Bok.  New insights and new approaches toward the study of age-related macular degeneration , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[9]  Masaru Miyagi,et al.  Drusen proteome analysis: An approach to the etiology of age-related macular degeneration , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[10]  Robert F Mullins,et al.  A role for local inflammation in the formation of drusen in the aging eye. , 2002, American journal of ophthalmology.

[11]  L. Packer,et al.  Bioflavonoid‐Rich Botanical Extracts Show Antioxidant and Gene Regulatory Activity , 2002, Annals of the New York Academy of Sciences.

[12]  J. Kane,et al.  Human retinal pigment epithelial cells express scavenger receptors BI and BII. , 2002, Biochemical and biophysical research communications.

[13]  V. Skulachev.  Programmed Death Phenomena: From Organelle to Organism , 2002, Annals of the New York Academy of Sciences.

[14]  T. Zglinicki,et al.  Replicative Aging, Telomeres, and Oxidative Stress , 2002, Annals of the New York Academy of Sciences.

[15]  Richard F Spaide,et al.  Lipid hydroperoxide stimulates subretinal choroidal neovascularization in the rabbit. , 2002, Experimental eye research.

[16]  J. Handa,et al.  Senescence associated β galactosidase activity in human retinal pigment epithelial cells exposed to mild hyperoxia in vitro , 2002, The British journal of ophthalmology.

[17]  I. Challis,et al.  Carotenoids Induce Apoptosis in the T-lymphoblast Cell Line Jurkat E6.1 , 2002, Free radical research.

[18]  Chunfang Zhang,et al.  Cellular Redox Activity of Coenzyme Q 10 : Effect of CoQ 10 Supplementation on Human Skeletal Muscle , 2002, Free radical research.

[19]  G. Siest,et al.  Differential Role of CYP2E1 Binders and Isoniazid on CYP2E1 Protein Modification in NADPH-dependent Microsomal Oxidative Reactions: Free Radical Scavenging Ability of Isoniazid , 2002, Free radical research.

[20]  E. Dennis,et al.  Scavenger Receptors, Oxidized LDL, and Atherosclerosis , 2001, Annals of the New York Academy of Sciences.

[21]  W. Willett,et al.  Dietary fat and risk for advanced age-related macular degeneration. , 2001, Archives of ophthalmology.

[22]  K. Shitara,et al.  VEGF Protects Against Oxidized LDL Toxicity to Endothelial Cells by an Intracellular Glutathione-Dependent Mechanism Through the KDR Receptor , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[23]  T. Hikichi,et al.  Pulsatile ocular blood flow study: decreases in exudative age related macular degeneration , 2001, The British journal of ophthalmology.

[24]  V. Sheffield,et al.  An analysis of allelic variation in the ABCA4 gene. , 2001, Investigative ophthalmology & visual science.

[25]  C Bellman,et al.  Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. , 2001, Investigative ophthalmology & visual science.

[26]  A Hofman,et al.  Risk factors for age-related macular degeneration: Pooled findings from three continents. , 2001, Ophthalmology.

[27]  K. Nakao,et al.  Oxidized LDL Regulates Vascular Endothelial Growth Factor Expression in Human Macrophages and Endothelial Cells Through Activation of Peroxisome Proliferator–Activated Receptor-&ggr; , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[28]  E. Rimm,et al.  Prospective study of dietary fat and the risk of age-related macular degeneration. , 2001, The American journal of clinical nutrition.

[29]  J L Haines,et al.  Association of the apolipoprotein E gene with age-related macular degeneration: possible effect modification by family history, age, and gender. , 2000, Molecular vision.

[30]  Andreas Wenzel,et al.  Age-related Macular Degeneration , 2000, The Journal of Biological Chemistry.

[31]  Ding-I Yang,et al.  iNOS expression inhibits hypoxia-inducible factor-1 activity. , 2000, Biochemical and biophysical research communications.

[32]  B. Fanburg,et al.  Reactive oxygen species in cell signaling. , 2000, American journal of physiology. Lung cellular and molecular physiology.

[33]  N. Maulik,et al.  Oxidative stress due to hypoxia/reoxygenation induces angiogenic factor VEGF in adult rat myocardium: possible role of NFkappaB. , 2000, Toxicology.

[34]  B. Brüne,et al.  Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway. , 2000, Biochemical and biophysical research communications.

[35]  M. Yuzawa,et al.  [Correlation of indocyanine green angiography findings and expression of vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes]. , 2000, Nippon Ganka Gakkai zasshi.

[36]  C. Rahner,et al.  Apoptosis induced by oxidized low density lipoprotein in human monocyte-derived macrophages involves CD36 and activation of caspase-3. , 2000, European journal of biochemistry.

[37]  K. Csaky,et al.  Choroidal neovascularization in the rat induced by adenovirus mediated expression of vascular endothelial growth factor. , 2000, Investigative ophthalmology & visual science.

[38]  P. Campochiaro,et al.  VEGF is major stimulator in model of choroidal neovascularization. , 2000, Investigative ophthalmology & visual science.

[39]  R. Linsenmeier,et al.  Metabolic dependence of photoreceptors on the choroid in the normal and detached retina. , 2000, Investigative ophthalmology & visual science.

[40]  M. Kitamura,et al.  Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways. , 2000, Kidney international.

[41]  K. Matsumoto,et al.  Oxidized LDL-induced NF-kappa B activation and subsequent expression of proinflammatory genes are defective in monocyte-derived macrophages from CD36-deficient patients. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[42]  K. Nose,et al.  Role of reactive oxygen species in the regulation of physiological functions. , 2000, Biological & pharmaceutical bulletin.

[43]  Y Sakai,et al.  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis , 2022 .

[44]  D. Shih,et al.  Endothelial responses to oxidized lipoproteins determine genetic susceptibility to atherosclerosis in mice. , 2000, Circulation.

[45]  I J Constable,et al.  Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium leads to the development of choroidal neovascularization. , 2000, The American journal of pathology.

[46]  C. Pang,et al.  The Apolipoprotein E ε4 Allele Is Unlikely to Be a Major Risk Factor of Age-Related Macular Degeneration in Chinese , 2000, Ophthalmologica.

[47]  T. Soussi.  The p53 Tumor Suppressor Gene: From Molecular Biology to Clinical Investigation , 2000, Annals of the New York Academy of Sciences.

[48]  Qin M. Chen,et al.  Replicative Senescence and Oxidant‐Induced Premature Senescence: Beyond the Control of Cell Cycle Checkpoints , 2000, Annals of the New York Academy of Sciences.

[49]  S. Ylä-Herttuala,et al.  Vascular protection: A novel nonangiogenic cardiovascular role for vascular endothelial growth factor. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[50]  Hiroshi Yamamoto,et al.  The Receptor for Advanced Glycation End Products Is Induced by the Glycation Products Themselves and Tumor Necrosis Factor-α through Nuclear Factor-κB, and by 17β-Estradiol through Sp-1 in Human Vascular Endothelial Cells* , 2000, The Journal of Biological Chemistry.

[51]  R Gopalakrishna,et al.  Protein kinase C signaling and oxidative stress. , 2000, Free radical biology & medicine.

[52]  Jihong Han,et al.  CD36 in Atherosclerosis: The Role of a Class B Macrophage Scavenger Receptor , 2000 .

[53]  D. Steinberg,et al.  Oxidized phospholipids, linked to apolipoprotein B of oxidized LDL, are ligands for macrophage scavenger receptors. , 2000, Journal of lipid research.

[54]  N. Bornfeld,et al.  Adhäsionseigenschaften der Basalmembranen der Bruchschen Membran. Immunhistochemische Untersuchungen der altersabhängigen Veränderungen von Adhäsionsmolekülen und Lipidablagerungen , 2000, Der Ophthalmologe.

[55]  P. Mitchell,et al.  Dietary fat and fish intake and age-related maculopathy. , 2000, Archives of ophthalmology.

[56]  H. H. Refsgaard,et al.  Modifications of proteins by polyunsaturated fatty acid peroxidation products. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[57]  L. Packer,et al.  mRNA expression profile of a human cancer cell line in response to Ginkgo biloba extract: Induction of antioxidant response and the golgi system , 2000, Free radical research.

[58]  K. Heimann,et al.  Cellular transport of subretinal material into choroidal and scleral blood vessels: an electron microscopic study , 1999, Graefe's Archive for Clinical and Experimental Ophthalmology.

[59]  Greene Wr.  Histopathology of age-related macular degeneration. , 1999, Molecular vision.

[60]  T. Kislinger,et al.  N ε-(Carboxymethyl)Lysine Adducts of Proteins Are Ligands for Receptor for Advanced Glycation End Products That Activate Cell Signaling Pathways and Modulate Gene Expression* , 1999, The Journal of Biological Chemistry.

[61]  M. Yanoff,et al.  Artificial senescence of bovine retinal pigment epithelial cells induced by near-ultraviolet in vitro , 1999, Mechanisms of Ageing and Development.

[62]  B. Godley,et al.  Induction of glutathione S-transferase hGST 5.8 is an early response to oxidative stress in RPE cells. , 1999, Investigative ophthalmology & visual science.

[63]  A C Bird,et al.  A fluorescein and indocyanine green angiographic study of choriocapillaris in age-related macular disease. , 1999, Archives of ophthalmology.

[64]  H. Grossniklaus,et al.  Histologic and morphometric analysis of the choroid, Bruch's membrane, and retinal pigment epithelium in postmortem eyes with age-related macular degeneration and histologic examination of surgically excised choroidal neovascular membranes. , 1999, Survey of ophthalmology.

[65]  Ivana K. Kim,et al.  Constitutive expression of VEGF, VEGFR-1, and VEGFR-2 in normal eyes. , 1999, Investigative ophthalmology & visual science.

[66]  J. Gilbert,et al.  Analysis of the Stargardt disease gene (ABCR) in age-related macular degeneration. , 1999, Ophthalmology.

[67]  D. Woolley,et al.  Neovascularization in early atherosclerotic lesions of human carotid arteries: its potential contribution to plaque development. , 1999, Human pathology.

[68]  A Kijlstra,et al.  Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relation. , 1999, The American journal of pathology.

[69]  W. Benedict,et al.  Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. , 1999, Science.

[70]  H. Hammes,et al.  Nε(carboxymethyl)lysin and the AGE receptor RAGE colocalize in age-related macular degeneration , 1999 .

[71]  Lynda Chin,et al.  p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis , 1999, Cell.

[72]  T. Jabs.  Reactive oxygen intermediates as mediators of programmed cell death in plants and animals. , 1999, Biochemical pharmacology.

[73]  S. Horiuchi,et al.  Advanced glycation end products in age-related macular degeneration. , 1998, Archives of ophthalmology.

[74]  A Hofman,et al.  Genetic risk of age-related maculopathy. Population-based familial aggregation study. , 1998, Archives of ophthalmology.

[75]  N. Tamura,et al.  Vascular endothelial growth factor (VEGF) expression in human coronary atherosclerotic lesions: possible pathophysiological significance of VEGF in progression of atherosclerosis. , 1998, Circulation.

[76]  K. Kawasaki,et al.  Upregulation of Retinal Vascular Endothelial Growth Factor mRNAs in Spontaneously Diabetic Rats without Ophthalmoscopic Retinopathy , 1998, Ophthalmic Research.

[77]  J. J. Wang,et al.  Refractive error and age-related maculopathy: the Blue Mountains Eye Study. , 1998, Investigative ophthalmology & visual science.

[78]  K. Pritchard,et al.  Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[79]  P. Mitchell,et al.  Family history and age-related maculopathy: the Blue Mountains Eye Study. , 1998, Australian and New Zealand journal of ophthalmology.

[80]  A. Hofman,et al.  Genetic association of apolipoprotein E with age-related macular degeneration. , 1998, American journal of human genetics.

[81]  M. Kuzuya,et al.  Induction of macrophage VEGF in response to oxidized LDL and VEGF accumulation in human atherosclerotic lesions. , 1998, Arteriosclerosis, thrombosis, and vascular biology.

[82]  H. Grossniklaus,et al.  Histopathologic and ultrastructural findings of surgically excised choroidal neovascularization. Submacular Surgery Trials Research Group. , 1998, Archives of ophthalmology.

[83]  N. Nakamura,et al.  Advanced glycation end products induce expression of vascular endothelial growth factor by retinal Muller cells. , 1997, Biochemical and biophysical research communications.

[84]  J. Miquel,et al.  An Update on the Oxygen Stress–Mitochondrial Mutation Theory of Aging: Genetic and Evolutionary Implications , 1998, Experimental Gerontology.

[85]  C. Bonne,et al.  Free radicals in retinal ischemia. , 1998, General pharmacology.

[86]  A. Munnich,et al.  The γ e4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration , 1998 .

[87]  D. Steinberg,et al.  Evidence that the lipid moiety of oxidized low density lipoprotein plays a role in its interaction with macrophage receptors. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[88]  Margaret A. Johnson,et al.  Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle , 1998, Annals of neurology.

[89]  A. Ho,et al.  Foveolar choroidal blood flow in age-related macular degeneration. , 1998, Investigative ophthalmology & visual science.

[90]  J. J. Wang,et al.  Gender, oestrogen, hormone replacement and age-related macular degeneration: results from the Blue Mountains Eye Study. , 1997, Australian and New Zealand journal of ophthalmology.

[91]  T. Luther,et al.  Advanced Glycation End Product-Induced Activation of NF-κB is Suppressed by α-Lipoic Acid in Cultured Endothelial Cells , 1997, Diabetes.

[92]  Jihong Han,et al.  Native and Modified Low Density Lipoproteins Increase the Functional Expression of the Macrophage Class B Scavenger Receptor, CD36* , 1997, The Journal of Biological Chemistry.

[93]  J. Shryock,et al.  Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology. , 1997, The American journal of cardiology.

[94]  K. Ikeda,et al.  The relationship between accumulation of advanced glycation end products and expression of vascular endothelial growth factor in human diabetic retinas , 1997, Diabetologia.

[95]  A. Bird,et al.  Ultrastructural findings in autosomal dominant drusen. , 1997, Archives of ophthalmology.

[96]  M. Batterbury,et al.  Pulsatile ocular blood flow measurements in healthy eyes: reproducibility and reference values. , 1997, Journal of glaucoma.

[97]  K. Alitalo,et al.  Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia , 1997, Oncogene.

[98]  B. Ames,et al.  Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[99]  M. Monte,et al.  Hydrogen peroxide is involved in lymphocyte activation mechanisms to induce angiogenesis. , 1997, European journal of cancer.

[100]  H. Sano,et al.  Advanced glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells. , 1997, The Biochemical journal.

[101]  J. Marshall,et al.  Localization of the site of major resistance to fluid transport in Bruch's membrane. , 1997, Investigative ophthalmology & visual science.

[102]  M. Katz,et al.  Formation of lipofuscin-like fluorophores by reaction of retinal with photoreceptor outer segments and liposomes , 1996, Mechanisms of Ageing and Development.

[103]  H. Dvorak,et al.  Correlation of vascular permeability factor/vascular endothelial growth factor with extraretinal neovascularization in the rat. , 1996, Archives of ophthalmology.

[104]  L. Aiello,et al.  Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells. , 1996, Investigative ophthalmology & visual science.

[105]  E. Voest,et al.  Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo. , 1996, The Journal of clinical investigation.

[106]  I. Constable,et al.  Correlation between autofluorescent debris accumulation and the presence of partially processed forms of cathepsin D in cultured retinal pigment epithelial cells challenged with rod outer segments. , 1996, Experimental eye research.

[107]  G. Lutty,et al.  Localization of vascular endothelial growth factor in human retina and choroid. , 1996, Archives of ophthalmology.

[108]  S. Seregard,et al.  Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor. , 1996, Investigative ophthalmology & visual science.

[109]  H. Sano,et al.  Advanced Glycation End Products and Their Recognition by Macrophage and Macrophage-Derived Cells , 1996, Diabetes.

[110]  M. Detmar,et al.  Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin. , 1996, The American journal of pathology.

[111]  T. Lyons,et al.  The Advanced Glycation End Product, N-(Carboxymethyl)lysine, Is a Product of both Lipid Peroxidation and Glycoxidation Reactions (*) , 1996, The Journal of Biological Chemistry.

[112]  D. Hinton,et al.  Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes. , 1996, Investigative ophthalmology & visual science.

[113]  J. Jonas,et al.  Retinal pigment epithelial cell count, distribution, and correlations in normal human eyes. , 1996, American journal of ophthalmology.

[114]  S. Ryeom,et al.  CD36 participates in the phagocytosis of rod outer segments by retinal pigment epithelium. , 1996, Journal of cell science.

[115]  J. J. Piotrowski,et al.  Mature human atherosclerotic plaque contains peroxidized phosphatidylcholine as a major lipid peroxide. , 1996, Life sciences.

[116]  U. Brunk,et al.  Lipofuscin formation in cultured retinal pigment epithelial cells exposed to photoreceptor outer segment material under different oxygen concentrations , 1996, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[117]  L. Aiello,et al.  Hypoxic regulation of vascular endothelial growth factor in retinal cells. , 1995, Archives of ophthalmology.

[118]  Y. Satow,et al.  Expression of the Vascular Endothelial Growth Factor ( VEGF ) Receptor Gene , KDR , in Hematopoietic Cells and Inhibitory Effect of VEGF on Apoptotic Cell Death Caused by Ionizing Radiation , 2022 .

[119]  A. Sica,et al.  A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter , 1995, The Journal of experimental medicine.

[120]  L. Aiello,et al.  Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[121]  D. Easty,et al.  Preparation of Bruch's membrane and analysis of the age-related changes in the structural collagens. , 1995, The British journal of ophthalmology.

[122]  J. Baynes,et al.  N epsilon-(carboxymethyl)lysine is a dominant advanced glycation end product (AGE) antigen in tissue proteins. , 1995, Biochemistry.

[123]  J. Marshall,et al.  Decreasing hydraulic conductivity of Bruch's membrane: relevance to photoreceptor survival and lipofuscinoses. , 1995, American journal of medical genetics.

[124]  M. Killingsworth.  Angiogenesis in early choroidal neovascularization secondary to age-related macular degeneration , 1995, Graefe's Archive for Clinical and Experimental Ophthalmology.

[125]  J. Marshall,et al.  Age-related variation in the hydraulic conductivity of Bruch's membrane. , 1995, Investigative ophthalmology & visual science.

[126]  G. Palade,et al.  Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. , 1995, Journal of cell science.

[127]  B. P. Yu,et al.  Lipid peroxidation contributes to age-related membrane rigidity. , 1995, Free radical biology & medicine.

[128]  B. Ames,et al.  Oxidative DNA damage and senescence of human diploid fibroblast cells. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[129]  H. Dvorak,et al.  Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. , 1995, The American journal of pathology.

[130]  E. Gaillard,et al.  PHOTOPHYSICAL STUDIES ON HUMAN RETINAL LIPOFUSCIN , 1995, Photochemistry and photobiology.

[131]  F W Fitzke,et al.  Distribution of fundus autofluorescence with a scanning laser ophthalmoscope. , 1995, The British journal of ophthalmology.

[132]  C K Dorey,et al.  In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. , 1995, Investigative ophthalmology & visual science.

[133]  T K Goldstick,et al.  Oxygen consumption in the inner and outer retina of the cat. , 1995, Investigative ophthalmology & visual science.

[134]  R. Alexander,et al.  Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells. , 1995, The Journal of clinical investigation.

[135]  C. Krakau.  A model for pulsatile and steady ocular blood flow , 1995, Graefe's Archive for Clinical and Experimental Ophthalmology.

[136]  Lois E. H. Smith,et al.  Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[137]  L. Aiello,et al.  Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. , 1994, The New England journal of medicine.

[138]  R Hiller,et al.  Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. , 1994, JAMA.

[139]  Lawrence A. Yannuzzi,et al.  Dietary Carotenoids, Vitamins A, C, and E, and Advanced Age-Related Macular Degeneration , 1994 .

[140]  K. Kage,et al.  Adenosine as an endogenous mediator of hypoxia for induction of vascular endothelial growth factor mRNA in U-937 cells. , 1994, Biochemical and biophysical research communications.

[141]  S M Schwartz,et al.  Angiogenesis in human coronary atherosclerotic plaques. , 1994, The American journal of pathology.

[142]  Joan W. Miller,et al.  Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. , 1994, The American journal of pathology.

[143]  P T de Jong,et al.  Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging. , 1994, Investigative ophthalmology & visual science.

[144]  J. Borowitz,et al.  Cyanide-induced lipid peroxidation in different organs: subcellular distribution and hydroperoxide generation in neuronal cells. , 1994, Toxicology.

[145]  D. Steinberg,et al.  Recognition of oxidatively damaged erythrocytes by a macrophage receptor with specificity for oxidized low density lipoprotein. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[146]  Y. Zou,et al.  Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. , 1994, The Journal of biological chemistry.

[147]  A. Bird,et al.  Analysis of lipid deposits extracted from human macular and peripheral Bruch's membrane. , 1994, Archives of ophthalmology.

[148]  R. S. Sohal,et al.  Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species. , 1993, Free radical biology & medicine.

[149]  R. Kendall,et al.  Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[150]  R. S. Sohal,et al.  Comparison of mitochondrial pro-oxidant generation and anti-oxidant defenses between rat and pigeon: possible basis of variation in longevity and metabolic potential , 1993, Mechanisms of Ageing and Development.

[151]  G. Semenza,et al.  Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. , 1993, The Journal of biological chemistry.

[152]  W R Green,et al.  Age-related Macular Degeneration Histopathologic Studies: The 1992 Lorenz E. Zimmerman Lecture , 1993, Ophthalmology.

[153]  S. Kondo,et al.  Significance of vascular endothelial growth factor/vascular permeability factor for solid tumor growth, and its inhibition by the antibody. , 1993, Biochemical and biophysical research communications.

[154]  R. Schott,et al.  Growth factors and angiogenesis. , 1993, Cardiovascular research.

[155]  Robert A. Linsenmeier,et al.  Oxygen distribution in the macaque retina. , 1993, Investigative ophthalmology & visual science.

[156]  G. Eldred,et al.  Retinal age pigments generated by self-assembling lysosomotropic detergents , 1993, Nature.

[157]  A. Bird,et al.  Correlation between biochemical composition and fluorescein binding of deposits in Bruch's membrane. , 1992, Ophthalmology.

[158]  J. S. Hyde,et al.  Oxygen diffusion-concentration product in rhodopsin as observed by a pulse ESR spin labeling method. , 1992, Biophysical journal.

[159]  J. S. Hyde,et al.  Is the mammalian cell plasma membrane a barrier to oxygen transport? , 1992, The Journal of general physiology.

[160]  A. Bird,et al.  Evolution of age-related macular degeneration with choroidal perfusion abnormality. , 1992, American journal of ophthalmology.

[161]  A. Bird,et al.  Functional loss in age-related Bruch's membrane change with choroidal perfusion defect. , 1992, Investigative ophthalmology & visual science.

[162]  H. Dvorak,et al.  Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. , 1992, Molecular biology of the cell.

[163]  R. Linsenmeier,et al.  Oxygen distribution and consumption in the cat retina during normoxia and hypoxemia , 1992, The Journal of general physiology.

[164]  J. S. Hyde,et al.  Effect of alkyl chain unsaturation and cholesterol intercalation on oxygen transport in membranes: a pulse ESR spin labeling study. , 1991, Biochemistry.

[165]  E. Berman,et al.  Lipids in human lipofuscin-enriched subcellular fractions of two age populations. Comparison with rod outer segments and neural retina. , 1990, Investigative ophthalmology & visual science.

[166]  D. Connolly,et al.  Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. , 1989, The Journal of clinical investigation.

[167]  J. Weiter,et al.  Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration. , 1989, Investigative ophthalmology & visual science.

[168]  J. S. Hyde,et al.  Oxygen permeability of phosphatidylcholine--cholesterol membranes. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[169]  R. Linsenmeier,et al.  Oxygen distribution and consumption in the cat retina at increased intraocular pressure. , 1989, Investigative ophthalmology & visual science.

[170]  J L Witztum,et al.  Low density lipoprotein undergoes oxidative modification in vivo. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[171]  M. Katz,et al.  Fluorophores of the human retinal pigment epithelium: separation and spectral characterization. , 1988, Experimental eye research.

[172]  A. Hruszkewycz.  Evidence for mitochondrial DNA damage by lipid peroxidation. , 1988, Biochemical and biophysical research communications.

[173]  R. Linsenmeier,et al.  The electroretinogram and choroidal PO2 in the cat during elevated intraocular pressure. , 1988, Investigative ophthalmology & visual science.

[174]  E. Rungger-Brändle,et al.  Exocytic clearing of degraded membrane material from pigment epithelial cells in frog retina. , 1987, Investigative ophthalmology & visual science.

[175]  K. Kikugawa,et al.  Involvement of lipid oxidation products in the formation of fluorescent and cross-linked proteins. , 1987, Chemistry and physics of lipids.

[176]  J. G. Marshall,et al.  Effects of increasing numbers of phagocytic inclusions on human retinal pigment epithelial cells in culture: a model for aging. , 1986, The British journal of ophthalmology.

[177]  K. Fukuzumi.  Relationship between lipoperoxides and diseases. , 1986, Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.

[178]  P. Penfold,et al.  Senile macular degeneration. The involvement of giant cells in atrophy of the retinal pigment epithelium. , 1986, Investigative ophthalmology & visual science.

[179]  R. E. Anderson,et al.  Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina. , 1983, Investigative ophthalmology & visual science.

[180]  F L Ferris,et al.  Senile macular degeneration: a case-control study. , 1983, American journal of epidemiology.

[181]  E. Berman,et al.  Lipofuscin of human retinal pigment epithelium. , 1980, American journal of ophthalmology.

[182]  Z. Gregor,et al.  Senile macular changes in the black African. , 1978, The British journal of ophthalmology.

[183]  J. Weiter,et al.  The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium. , 1978, Investigative ophthalmology & visual science.

[184]  Chumbley Lc.  Impressions of eye diseases among Rhodesian Blacks in Mashonaland. , 1977 .

[185]  Denham Harman,et al.  The Biologic Clock: The Mitochondria? , 1972, Journal of the American Geriatrics Society.

[186]  D. Bok,et al.  Practical Remarks on Gout, Rheumatic Fever, and Chonic Rheumatism of the Joints; Being the Substance of the Croonian Lectures for the Present Year, Delivered at the College of Physicians , 1844, Edinburgh Medical and Surgical Journal.

[187]  P. Penfold,et al.  Senile macular degeneration: The involvement of immunocompetent cells , 2005, Graefe's Archive for Clinical and Experimental Ophthalmology.

[188]  P. Jong,et al.  Immunohistochemical light and electron microscopy of basal laminar deposit , 2004, Graefe's Archive for Clinical and Experimental Ophthalmology.

[189]  R. Browne,et al.  Lipid hydroperoxide stimulates retinal neovascularization in rabbit retina through expression of tumor necrosis factor-a, vascular endothelial growth factor and platelet-derived growth factor , 2004, Angiogenesis.

[190]  R. Evans,et al.  PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation , 2001, Nature Medicine.

[191]  W. Colucci,et al.  Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts. , 2001, American journal of physiology. Cell physiology.

[192]  C. Curcio,et al.  Accumulation of cholesterol with age in human Bruch's membrane. , 2001, Investigative ophthalmology & visual science.

[193]  Jennifer I. Lim,et al.  A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. , 2001, Archives of ophthalmology.

[194]  A. Heiligenhaus,et al.  [Adhesive properties of basal membranes of Bruch's membrane. Immunohistochemical studies of age-dependent changes in adhesive molecules and lipid deposits]. , 2000, Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft.

[195]  H. Yamamoto,et al.  The receptor for advanced glycation end products is induced by the glycation products themselves and tumor necrosis factor-alpha through nuclear factor-kappa B, and by 17beta-estradiol through Sp-1 in human vascular endothelial cells. , 2000, The Journal of biological chemistry.

[196]  P. Campochiaro,et al.  Sensitivity of different vascular beds in the eye to neovascularization and blood-retinal barrier breakdown in VEGF transgenic mice. , 2000, Advances in experimental medicine and biology.

[197]  W. Green,et al.  Histopathology of age-related macular degeneration. , 1999, Molecular vision.

[198]  P. Campochiaro,et al.  Role of hypoxia and extracellular matrix-integrin binding in the modulation of angiogenic growth factors secretion by retinal pigmented epithelial cells. , 1999, Journal of cellular biochemistry.

[199]  H. Hammes,et al.  N(epsilon)(carboxymethyl)lysin and the AGE receptor RAGE colocalize in age-related macular degeneration. , 1999, Investigative ophthalmology & visual science.

[200]  R. Browne,et al.  Characterization of peroxidized lipids in Bruch's membrane. , 1999, Retina.

[201]  R. Danis,et al.  Presumed macular choroidal watershed vascular filling, choroidal neovascularization, and systemic vascular disease in patients with age-related macular degeneration. , 1998, American journal of ophthalmology.

[202]  A. Munnich,et al.  The epsilon4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration. , 1998, American journal of ophthalmology.

[203]  P. Lelkes,et al.  On the possible role of reactive oxygen species in angiogenesis. , 1998, Advances in experimental medicine and biology.

[204]  K. Gitter,et al.  Presumed macular choroidal watershed vascular filling, choroidal neovascularization, and systemic vascular disease in patients with age-related macular degeneration. , 1998, American journal of ophthalmology.

[205]  J. Folkman,et al.  Angiogenesis and angiogenesis inhibition: an overview. , 1997, EXS.

[206]  T. Luther,et al.  Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells. , 1997, Diabetes.

[207]  P. Bernstein,et al.  Retinal tubulin binds macular carotenoids. , 1997, Investigative ophthalmology & visual science.

[208]  U. Brunk,et al.  Lipofuscin accumulation in cultured retinal pigment epithelial cells causes enhanced sensitivity to blue light irradiation. , 1997, Free radical biology & medicine.

[209]  R. Dean,et al.  Separation and characterization of cholesteryl oxo- and hydroxy-linoleate isolated from human atherosclerotic plaque. , 1997, Free radical research.

[210]  J. Lupski,et al.  Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. , 1997, Science.

[211]  R. Klein,et al.  The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. , 1997, Ophthalmology.

[212]  Judith Alexander,et al.  Risk factors for choroidal neovascularization in the second eye of patients with juxtafoveal or subfoveal choroidal neovascularization secondary to age-related macular degeneration. Macular Photocoagulation Study Group. , 1997, Archives of ophthalmology.

[213]  D. Yin,et al.  Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores. , 1996, Free radical biology & medicine.

[214]  J. Folkman,et al.  Hypoxic induction of endothelial cell growth factors in retinal cells: identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen. , 1995, Molecular medicine.

[215]  G. Eldred.  Lipofuscin fluorophore inhibits lysosomal protein degradation and may cause early stages of macular degeneration. , 1995, Gerontology.

[216]  J. Caro,et al.  Hypoxia regulatory elements of the human vascular endothelial growth factor gene. , 1994, Cellular & molecular biology research.

[217]  M. Killingsworth,et al.  Evolution of soft drusen in age-related macular degeneration , 1994, Eye.

[218]  A. Bird,et al.  Correlation between lipids extracted from Bruch's membrane and age. , 1993, Ophthalmology.

[219]  H. Gao,et al.  Aging of the human retina. Differential loss of neurons and retinal pigment epithelial cells. , 1992, Investigative ophthalmology & visual science.

[220]  Risk factors for neovascular age-related macular degeneration. The Eye Disease Case-Control Study Group. , 1992, Archives of ophthalmology.

[221]  P. D. de Jong,et al.  Is basal laminar deposit unique for age-related macular degeneration? , 1991, Archives of ophthalmology.

[222]  S. Hayasaka.  Aging changes in lipofuscin, lysosomes and melanin in the macular area of human retina and choroid. , 1989, Japanese journal of ophthalmology.

[223]  M. Boulton,et al.  The formation of autofluorescent granules in cultured human RPE. , 1989, Investigative ophthalmology & visual science.

[224]  K. Kikugawa,et al.  Fluorescent and cross-linked proteins formed by free radical and aldehyde species generated during lipid oxidation. , 1989, Advances in experimental medicine and biology.

[225]  G. Korte,et al.  Choriocapillaris regeneration in the rabbit: a study with vascular casts. , 1988, Acta anatomica.

[226]  J. Marshall,et al.  The ageing retina: Physiology or pathology , 1987, Eye.

[227]  T. Ishibashi,et al.  Aging changes in Bruch's membrane of monkeys: an electron microscopic study. , 1986, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde.

[228]  M. Matsumura,et al.  Exocytosis by retinal pigment epithelial cells. , 1985, Ophthalmic Research.

[229]  L. Chumbley.  Impressions of eye diseases among Rhodesian Blacks in Mashonaland. , 1977, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.