C957T DRD2 polymorphism is associated with schizophrenia in Spanish patients

Objective:  The objective was to confirm whether a homozygous genotype for the C957 allele of the C957T DRD2 gene single nucleotide polymorphism (SNP) is associated with schizophrenia in an independent study population.

[1]  Laurent Gouya,et al.  The 3′ region of the DRD2 gene is involved in genetic susceptibility to schizophrenia , 2004, Schizophrenia Research.

[2]  J. Basilion,et al.  Single-nucleotide polymorphisms can cause different structural folds of mRNA. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[3]  S. Kapur,et al.  Schizophrenia: more dopamine, more D2 receptors. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[4]  N. Saitou,et al.  Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. , 2003, Human molecular genetics.

[5]  C. P. Morris,et al.  The C/C genotype of the C957T polymorphism of the dopamine D2 receptor is associated with schizophrenia , 2005, Schizophrenia Research.

[6]  R. Murray,et al.  Heritability estimates for psychotic disorders: the Maudsley twin psychosis series. , 1999, Archives of general psychiatry.

[7]  J. Scharfetter.  Pharmacogenetics of dopamine receptors and response to antipsychotic drugs in schizophrenia--an update. , 2004, Pharmacogenomics.

[8]  G. Kirov,et al.  Finding schizophrenia genes. , 2005, The Journal of clinical investigation.

[9]  Samir K. Brahmachari,et al.  Association of DRD2 gene variant with schizophrenia , 2006, Neuroscience Letters.