Temporal Dynamics Underlying Perceptual Decision Making: Insights from the Interplay between an Attractor Model and Parietal Neurophysiology

Recent neurophysiological studies in awake, behaving primates have revealed that neurons in certain brain areas appear to integrate sensory evidence over time during the performance of perceptual decision-making tasks. Neurons in the lateral intraparietal area (LIP) of rhesus monkeys exhibit such decision-related signals while the animals view and judge the direction of a visual motion display. Further investigation of this temporal integration process using brief perturbations of the sensory evidence has suggested that LIP neurons do not integrate evidence in a perfect, linear manner. We describe how a biophysically-plausible attractor network model can account for many aspects of the temporal dynamics of neural activity during these perceptual decisions. We also review a larger set of models and explain how the dynamics during and after temporal integration can help to distinguish the underlying neural mechanisms. Finally, we propose some crucial theoretically-motivated experiments that are needed to test among models.

[1]  J. Movshon,et al.  A computational analysis of the relationship between neuronal and behavioral responses to visual motion , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[2]  J. Gold,et al.  The neural basis of decision making. , 2007, Annual review of neuroscience.

[3]  X. Wang,et al.  Synaptic Basis of Cortical Persistent Activity: the Importance of NMDA Receptors to Working Memory , 1999, The Journal of Neuroscience.

[4]  M. Stone.  Models for choice-reaction time , 1960 .

[5]  R. Romo,et al.  Neuronal correlates of parametric working memory in the prefrontal cortex , 1999, Nature.

[6]  P. Holmes,et al.  MODELING A SIMPLE CHOICE TASK: STOCHASTIC DYNAMICS OF MUTUALLY INHIBITORY NEURAL GROUPS , 2001 .

[7]  Anders Ledberg,et al.  Neurobiological Models of Two-Choice Decision Making Can Be Reduced to a One-Dimensional Nonlinear Diffusion Equation , 2008, PLoS Comput. Biol..

[8]  M N Shadlen,et al.  Motion perception: seeing and deciding. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[9]  Xiao-Jing Wang,et al.  Cortico–basal ganglia circuit mechanism for a decision threshold in reaction time tasks , 2006, Nature Neuroscience.

[10]  David L. Sparks,et al.  Movement selection in advance of action in the superior colliculus , 1992, Nature.

[11]  Jeffrey D. Schall,et al.  Neural basis of deciding, choosing and acting , 2001, Nature Reviews Neuroscience.

[12]  A. Parker,et al.  Sense and the single neuron: probing the physiology of perception. , 1998, Annual review of neuroscience.

[13]  Roger Ratcliff,et al.  The Diffusion Decision Model: Theory and Data for Two-Choice Decision Tasks , 2008, Neural Computation.

[14]  Xiao-Jing Wang,et al.  Probabilistic Decision Making by Slow Reverberation in Cortical Circuits , 2002, Neuron.

[15]  W. Newsome,et al.  Deciding about motion: linking perception to action , 1997, Journal of Comparative Physiology A.

[16]  J. Townsend,et al.  Decision field theory: a dynamic-cognitive approach to decision making in an uncertain environment. , 1993, Psychological review.

[17]  R. Andersen,et al.  Memory related motor planning activity in posterior parietal cortex of macaque , 1988, Experimental Brain Research.

[18]  William T. Newsome,et al.  Cortical microstimulation influences perceptual judgements of motion direction , 1990, Nature.

[19]  Jonathan D. Cohen,et al.  The physics of optimal decision making: a formal analysis of models of performance in two-alternative forced-choice tasks. , 2006, Psychological review.

[20]  J. Fuster.  Prefrontal Cortex , 2018 .

[21]  M. Shadlen,et al.  The effect of stimulus strength on the speed and accuracy of a perceptual decision. , 2005, Journal of vision.

[22]  J. Movshon,et al.  The analysis of visual motion: a comparison of neuronal and psychophysical performance , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[23]  P. Glimcher.  The neurobiology of visual-saccadic decision making. , 2003, Annual review of neuroscience.

[24]  Philip L. Smith,et al.  Psychology and neurobiology of simple decisions , 2004, Trends in Neurosciences.

[25]  M. Shadlen,et al.  Neural Activity in Macaque Parietal Cortex Reflects Temporal Integration of Visual Motion Signals during Perceptual Decision Making , 2005, The Journal of Neuroscience.

[26]  Philip L. Smith,et al.  A comparison of sequential sampling models for two-choice reaction time. , 2004, Psychological review.

[27]  M. Shadlen,et al.  Decision-making with multiple alternatives , 2008, Nature Neuroscience.

[28]  Jeffrey D. Schall,et al.  Relationship of presaccadic activity in frontal eye field and supplementary eye field to saccade initiation in macaque: Poisson spike train analysis , 2004, Experimental Brain Research.

[29]  M. Shadlen,et al.  A role for neural integrators in perceptual decision making. , 2003, Cerebral cortex.

[30]  Philip Holmes,et al.  Simple Neural Networks that Optimize Decisions , 2005, Int. J. Bifurc. Chaos.

[31]  James L. McClelland,et al.  The time course of perceptual choice: the leaky, competing accumulator model. , 2001, Psychological review.

[32]  K. H. Britten,et al.  Responses of neurons in macaque MT to stochastic motion signals , 1993, Visual Neuroscience.

[33]  Timothy D. Hanks,et al.  Bounded Integration in Parietal Cortex Underlies Decisions Even When Viewing Duration Is Dictated by the Environment , 2008, The Journal of Neuroscience.

[34]  W. Newsome,et al.  The King Solomon Lectures in Neuroethology. Deciding about motion: linking perception to action. , 1997, Journal of comparative physiology. A, Sensory, neural, and behavioral physiology.

[35]  Donald Laming,et al.  Information theory of choice-reaction times , 1968 .

[36]  Roger Ratcliff,et al.  A Theory of Memory Retrieval. , 1978 .

[37]  S. Link,et al.  A sequential theory of psychological discrimination , 1975 .

[38]  W. Newsome,et al.  Choosing the greater of two goods: neural currencies for valuation and decision making , 2005, Nature Reviews Neuroscience.

[39]  K. H. Britten,et al.  Neuronal correlates of a perceptual decision , 1989, Nature.

[40]  Xiao-Jing Wang,et al.  A Recurrent Network Mechanism of Time Integration in Perceptual Decisions , 2006, The Journal of Neuroscience.

[41]  J. Schall.  Neural correlates of decision processes: neural and mental chronometry , 2003, Current Opinion in Neurobiology.

[42]  Michele A. Basso,et al.  Modulation of neuronal activity by target uncertainty , 1997, Nature.

[43]  R. Ratcliff,et al.  Connectionist and diffusion models of reaction time. , 1999, Psychological review.

[44]  KongFatt Wong-Lin,et al.  Neural Circuit Dynamics Underlying Accumulation of Time-Varying Evidence During Perceptual Decision Making , 2007, Frontiers Comput. Neurosci..

[45]  M. Shadlen,et al.  Response of Neurons in the Lateral Intraparietal Area during a Combined Visual Discrimination Reaction Time Task , 2002, The Journal of Neuroscience.

[46]  J. Gold,et al.  Neural computations that underlie decisions about sensory stimuli , 2001, Trends in Cognitive Sciences.