Mesoporous silica nanoparticles as cutting‐edge theranostics: Advancement from merely a carrier to tailor‐made smart delivery platform
暂无分享,去创建一个
[1] K. Paknikar,et al. A robust pH-sensitive unimolecular dendritic nanocarrier that enables targeted anti-cancer drug delivery via GLUT transporters. , 2018, Colloids and surfaces. B, Biointerfaces.
[2] Wenli Zhang,et al. Particle morphology: an important factor affecting drug delivery by nanocarriers into solid tumors , 2018, Expert opinion on drug delivery.
[3] Z. Wang,et al. Shape Engineering Boosts Magnetic Mesoporous Silica Nanoparticle-Based Isolation and Detection of Circulating Tumor Cells. , 2018, ACS applied materials & interfaces.
[4] Wenwen Guo,et al. Small size mesoporous organosilica nanorods with different aspect ratios: Synthesis and cellular uptake. , 2018, Journal of colloid and interface science.
[5] K. Paknikar,et al. Triptorelin Tethered Multifunctional PAMAM-Histidine-PEG Nanoconstructs Enable Specific Targeting and Efficient Gene Silencing in LHRH Overexpressing Cancer Cells. , 2017, ACS applied materials & interfaces.
[6] V. Konda,et al. Lectin-functionalized mesoporous silica nanoparticles for endoscopic detection of premalignant colonic lesions. , 2017, Nanomedicine : nanotechnology, biology, and medicine.
[7] K. Paknikar,et al. Folate/N-acetyl glucosamine conjugated mesoporous silica nanoparticles for targeting breast cancer cells: A comparative study. , 2017, Colloids and surfaces. B, Biointerfaces.
[8] B. Özbek,et al. Preparation and characterization of polymer-coated mesoporous silica nanoparticles and their application in Subtilisin immobilization , 2017, Korean Journal of Chemical Engineering.
[9] S. M. Taghdisi,et al. Synthesis of theranostic epithelial cell adhesion molecule targeted mesoporous silica nanoparticle with gold gatekeeper for hepatocellular carcinoma. , 2017, Nanomedicine.
[10] L. Qi,et al. Cyclodextrin-gated mesoporous silica nanoparticles as drug carriers for red light-induced drug release , 2017, Nanotechnology.
[11] M. Vallet‐Regí,et al. Recent applications of the combination of mesoporous silica nanoparticles with nucleic acids: development of bioresponsive devices, carriers and sensors. , 2017, Biomaterials science.
[12] M. I. Setyawati,et al. Mesoporous Silica Nanoparticles as an Antitumoral-Angiogenesis Strategy. , 2017, ACS applied materials & interfaces.
[13] Jing Li,et al. The shape effect of magnetic mesoporous silica nanoparticles on endocytosis, biocompatibility and biodistribution. , 2017, Acta biomaterialia.
[14] Lin Shi,et al. Polydopamine and peptide decorated doxorubicin-loaded mesoporous silica nanoparticles as a targeted drug delivery system for bladder cancer therapy , 2017, Drug delivery.
[15] B. Trewyn,et al. Controlled release and intracellular protein delivery from mesoporous silica nanoparticles , 2017, Biotechnology journal.
[16] T. Bein,et al. Talented Mesoporous Silica Nanoparticles , 2017 .
[17] Shiguo Sun,et al. Construction of A Triple-Stimuli-Responsive System Based on Cerium Oxide Coated Mesoporous Silica Nanoparticles , 2016, Scientific Reports.
[18] Juan L. Vivero-Escoto,et al. Mucin-1-Antibody-Conjugated Mesoporous Silica Nanoparticles for Selective Breast Cancer Detection in a Mucin-1 Transgenic Murine Mouse Model. , 2016, Journal of biomedical nanotechnology.
[19] Juan L. Vivero-Escoto,et al. In vitro evaluation of folic acid-conjugated redox-responsive mesoporous silica nanoparticles for the delivery of cisplatin , 2016, International journal of nanomedicine.
[20] Chengzhong Yu,et al. Amine functionalized cubic mesoporous silica nanoparticles as an oral delivery system for curcumin bioavailability enhancement , 2016, Nanotechnology.
[21] Huajian Gao,et al. Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues. , 2016, Nano letters.
[22] M. Gonen,et al. Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth , 2016, Nature nanotechnology.
[23] A. Schmidtchen,et al. Membrane interactions of mesoporous silica nanoparticles as carriers of antimicrobial peptides. , 2016, Journal of colloid and interface science.
[24] A. Winkel,et al. pH-responsive release of chlorhexidine from modified nanoporous silica nanoparticles for dental applications , 2016 .
[25] L. De Cola,et al. Breakable mesoporous silica nanoparticles for targeted drug delivery. , 2016, Nanoscale.
[26] M. Maynadier,et al. 20-nm-sized mesoporous silica nanoparticles with porphyrin photosensitizers for in vitro photodynamic therapy , 2016, Journal of Sol-Gel Science and Technology.
[27] M. Maynadier,et al. Multifunctional Gold-Mesoporous Silica Nanocomposites for Enhanced Two-Photon Imaging and Therapy of Cancer Cells , 2016, Front. Mol. Biosci..
[28] Mika Linden,et al. Mesoporous silica nanoparticles in tissue engineering--a perspective. , 2016, Nanomedicine.
[29] D. Leong,et al. Cytotoxic Effects of Phosphonate-Functionalized Mesoporous Silica Nanoparticles. , 2016, ACS applied materials & interfaces.
[30] A. Farghali,et al. Mesoporous Silica Materials in Drug Delivery System: pH/Glutathione-Responsive Release of Poorly Water-Soluble Pro-drug Quercetin fromTwo and Three-dimensional Pore-Structure Nanoparticles , 2016 .
[31] Guo-Feng Luo,et al. Enzyme-induced and tumor-targeted drug delivery system based on multifunctional mesoporous silica nanoparticles. , 2015, ACS applied materials & interfaces.
[32] Zhouhua Wang,et al. Lactosaminated mesoporous silica nanoparticles for asialoglycoprotein receptor targeted anticancer drug delivery , 2015, Journal of Nanobiotechnology.
[33] R. Mangues,et al. Gated Mesoporous Silica Nanoparticles Using a Double‐Role Circular Peptide for the Controlled and Target‐Preferential Release of Doxorubicin in CXCR4‐Expresing Lymphoma Cells , 2015 .
[34] Yi-xiao Luo,et al. Monocyte mediated brain targeting delivery of macromolecular drug for the therapy of depression. , 2015, Nanomedicine : nanotechnology, biology, and medicine.
[35] K. Kikuchi,et al. Mesoporous silica nanoparticles for 19F magnetic resonance imaging, fluorescence imaging, and drug delivery† †Electronic supplementary information (ESI) available: Detailed synthetic procedure, experimental procedure and Fig. S1–S7. See DOI: 10.1039/c4sc03549f Click here for additional data file. , 2014, Chemical science.
[36] S. Mortazavi,et al. Preparation and Characterization of Rifampin Loaded Mesoporous Silica Nanoparticles as a Potential System for Pulmonary Drug Delivery , 2015, Iranian journal of pharmaceutical research : IJPR.
[37] Qinfu Zhao,et al. Development of phosphonate-terminated magnetic mesoporous silica nanoparticles for pH-controlled release of doxorubicin and improved tumor accumulation , 2014 .
[38] H. Gu,et al. Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier. , 2014, Biomaterials.
[39] Mithat Gönen,et al. Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe , 2014, Science Translational Medicine.
[40] J. Kong,et al. In situ monitoring of intracellular controlled drug release from mesoporous silica nanoparticles coated with pH-responsive charge-reversal polymer. , 2014, ACS applied materials & interfaces.
[41] Yikun Gao,et al. Alginate encapsulated mesoporous silica nanospheres as a sustained drug delivery system for the poorly water-soluble drug indomethacin , 2014 .
[42] Yanli Zhao,et al. Intracellular delivery of antisense peptide nucleic acid by fluorescent mesoporous silica nanoparticles. , 2014, Bioconjugate chemistry.
[43] C. Choong,et al. Redox-responsive mesoporous silica nanoparticles: a physiologically sensitive codelivery vehicle for siRNA and doxorubicin. , 2014, Antioxidants & redox signaling.
[44] Jian-tao Lin,et al. Mesoporous silica nanoparticles with controlled loading of cationic dendrimer for gene delivery , 2014 .
[45] Jiashing Yu,et al. Liver cancer cells: targeting and prolonged-release drug carriers consisting of mesoporous silica nanoparticles and alginate microspheres , 2014, International journal of nanomedicine.
[46] S. Mohapatra,et al. Luminescent magnetic hollow mesoporous silica nanotheranostics for camptothecin delivery and multimodal imaging. , 2014, Journal of materials chemistry. B.
[47] H. Gu,et al. Iodinated oil-loaded, fluorescent mesoporous silica-coated iron oxide nanoparticles for magnetic resonance imaging/computed tomography/fluorescence trimodal imaging , 2014, International journal of nanomedicine.
[48] Wei Wang,et al. pH-responsive mesoporous silica nanoparticles employed in controlled drug delivery systems for cancer treatment , 2014, Cancer biology & medicine.
[49] Jun-Jie Zhu,et al. DNA-hybrid-gated multifunctional mesoporous silica nanocarriers for dual-targeted and microRNA-responsive controlled drug delivery. , 2014, Angewandte Chemie.
[50] Jianliang Shen,et al. Cyclodextrin and Polyethylenimine Functionalized Mesoporous Silica Nanoparticles for Delivery of siRNA Cancer Therapeutics , 2014, Theranostics.
[51] J. Westermarck,et al. Mesoporous silica nanoparticles with redox-responsive surface linkers for charge-reversible loading and release of short oligonucleotides. , 2014, Dalton transactions.
[52] Xinling Wang,et al. Mesoporous SBA-15 end-capped by PEG via l-cystine based linker for redox responsive controlled release , 2014 .
[53] Yuhan Sun,et al. Applicability of enzyme-responsive mesoporous silica supports capped with bridged silsesquioxane for colon-specific drug delivery , 2014 .
[54] Chengzhong Yu,et al. Functionalized large pore mesoporous silica nanoparticles for gene delivery featuring controlled release and co-delivery. , 2014, Journal of materials chemistry. B.
[55] Maili Liu,et al. pH-Triggered Au-fluorescent mesoporous silica nanoparticles for 19F MR/fluorescent multimodal cancer cellular imaging. , 2014, Chemical communications.
[56] Krishanu Saha,et al. Drug-loaded nanoparticles induce gene expression in human pluripotent stem cell derivatives. , 2014, Nanoscale.
[57] N. Young,et al. Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug Delivery , 2014 .
[58] Xiaoxi Hu,et al. Chitosan-capped mesoporous silica nanoparticles as pH-responsive nanocarriers for controlled drug release. , 2014, Chemistry, an Asian journal.
[59] E. Parfenyuk,et al. Different Effects of the Immunomodulatory Drug GMDP Immobilized onto Aminopropyl Modified and Unmodified Mesoporous Silica Nanoparticles upon Peritoneal Macrophages of Women with Endometriosis , 2013, BioMed research international.
[60] Feng Chen,et al. Biomedical applications of functionalized hollow mesoporous silica nanoparticles: focusing on molecular imaging. , 2013, Nanomedicine.
[61] Dhakshinamoorthy Sundaramurthi,et al. Hierarchical mesoporous silica nanofibers as multifunctional scaffolds for bone tissue regeneration , 2013, Journal of biomaterials science. Polymer edition.
[62] V. Berezin,et al. Delivery of Differentiation Factors by Mesoporous Silica Particles Assists Advanced Differentiation of Transplanted Murine Embryonic Stem Cells , 2013, Stem cells translational medicine.
[63] Hao Hong,et al. In vivo tumor targeting and image-guided drug delivery with antibody-conjugated, radiolabeled mesoporous silica nanoparticles. , 2013, ACS nano.
[64] Xiangyang Zhu,et al. Sub-150 nm mesoporous silica nanoparticles with tunable pore sizes and well-ordered mesostructure for protein encapsulation. , 2013, Journal of colloid and interface science.
[65] Sang Bong Lee,et al. Mesoporous silica nanoparticle pretargeting for PET imaging based on a rapid bioorthogonal reaction in a living body. , 2013, Angewandte Chemie.
[66] Zipeng Zhen,et al. Label-Free Luminescent Mesoporous Silica Nanoparticles for Imaging and Drug Delivery , 2013, Theranostics.
[67] N. Mitter,et al. Mesoporous silica nanoparticles as antigen carriers and adjuvants for vaccine delivery. , 2013, Nanoscale.
[68] Y. Luan,et al. Folate-conjugated hybrid SBA-15 particles for targeted anticancer drug delivery. , 2013, Journal of colloid and interface science.
[69] Bo Li,et al. Hybrid nanoparticles for drug delivery and bioimaging: mesoporous silica nanoparticles functionalized with carboxyl groups and a near-infrared fluorescent dye. , 2013, Journal of colloid and interface science.
[70] Yizhong Lu,et al. Fabrication of Heparinized Mesoporous Silica Nanoparticles as Multifunctional Drug Carriers , 2013 .
[71] Yufang Zhu,et al. Preparation of chitosan/mesoporous silica nanoparticle composite hydrogels for sustained co-delivery of biomacromolecules and small chemical drugs , 2013, Science and technology of advanced materials.
[72] Robert J Gillies,et al. Acidity generated by the tumor microenvironment drives local invasion. , 2013, Cancer research.
[73] Eric C. Carnes,et al. Mesoporous silica nanoparticle nanocarriers: biofunctionality and biocompatibility. , 2013, Accounts of chemical research.
[74] Huan Meng,et al. Mesoporous silica nanoparticles: A multifunctional nano therapeutic system. , 2013, Integrative biology : quantitative biosciences from nano to macro.
[75] H. Gu,et al. A mesoporous silica nanoparticle--PEI--fusogenic peptide system for siRNA delivery in cancer therapy. , 2013, Biomaterials.
[76] Yanli Zhao,et al. Multifunctional Mesoporous Silica Nanoparticles for Cancer‐Targeted and Controlled Drug Delivery , 2012 .
[77] Z. Alothman. A Review: Fundamental Aspects of Silicate Mesoporous Materials , 2012, Materials.
[78] Juqun Xi,et al. Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery , 2012, International journal of nanomedicine.
[79] P. Ducheyne,et al. Polymer-coated mesoporous silica nanoparticles for the controlled release of macromolecules. , 2012, Acta biomaterialia.
[80] T. Asefa,et al. Biocompatibility of mesoporous silica nanoparticles. , 2012, Chemical research in toxicology.
[81] Hiroaki Sai,et al. Ultrasmall sub-10 nm near-infrared fluorescent mesoporous silica nanoparticles. , 2012, Journal of the American Chemical Society.
[82] Xiaobing Zhang,et al. Photon-manipulated drug release from a mesoporous nanocontainer controlled by azobenzene-modified nucleic acid. , 2012, ACS nano.
[83] Huizhi Guo,et al. Immunization of mice by Hollow Mesoporous Silica Nanoparticles as carriers of Porcine Circovirus Type 2 ORF2 Protein , 2012, Virology Journal.
[84] Changbong Hyeon,et al. Efficient functional delivery of siRNA using mesoporous silica nanoparticles with ultralarge pores. , 2012, Small.
[85] G. Mao,et al. Surface Functionalization of Mesoporous Silica Nanoparticles Controls Loading and Release Behavior of Mitoxantrone , 2012, Pharmaceutical Research.
[86] Zongxi Li,et al. Mesoporous silica nanoparticles in biomedical applications. , 2012, Chemical Society reviews.
[87] H. Gu,et al. Delivering hydrophilic and hydrophobic chemotherapeutics simultaneously by magnetic mesoporous silica nanoparticles to inhibit cancer cells , 2012, International journal of nanomedicine.
[88] Jeffrey I. Zink,et al. Targeted Intracellular Delivery of Antituberculosis Drugs to Mycobacterium tuberculosis-Infected Macrophages via Functionalized Mesoporous Silica Nanoparticles , 2012, Antimicrobial Agents and Chemotherapy.
[89] Liang Wang,et al. Near-infrared quantum dots for HER2 localization and imaging of cancer cells , 2014, International journal of nanomedicine.
[90] J. Zink,et al. In vivo tumor suppression efficacy of mesoporous silica nanoparticles-based drug-delivery system: enhanced efficacy by folate modification. , 2012, Nanomedicine : nanotechnology, biology, and medicine.
[91] G. Lu,et al. Magnetic silica spheres with large nanopores for nucleic acid adsorption and cellular uptake. , 2012, Biomaterials.
[92] Hongchen Gu,et al. The packaging of siRNA within the mesoporous structure of silica nanoparticles. , 2011, Biomaterials.
[93] Michael J. Sailor,et al. Bioresponsive Mesoporous Silica Nanoparticles for Triggered Drug Release , 2011, Journal of the American Chemical Society.
[94] X. Ji,et al. A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance. , 2011, Biomaterials.
[95] Cecilia Sahlgren,et al. Mesoporous silica nanoparticles as drug delivery systems for targeted inhibition of Notch signaling in cancer. , 2011, Molecular therapy : the journal of the American Society of Gene Therapy.
[96] Kazunori Kataoka,et al. Supramolecular nanodevices: from design validation to theranostic nanomedicine. , 2011, Accounts of chemical research.
[97] Xing-Jie Liang,et al. Theranostic nanoparticles engineered for clinic and pharmaceutics. , 2011, Accounts of chemical research.
[98] Courtney R. Thomas,et al. Synthesis of biomolecule-modified mesoporous silica nanoparticles for targeted hydrophobic drug delivery to cancer cells. , 2011, Small.
[99] Dong Chen,et al. The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo. , 2011, ACS nano.
[100] Y. Hsiao,et al. Multifunctional Mesoporous Silica-Coated Hollow Manganese Oxide Nanoparticles for Targeted Optical Imaging, T 1 Magnetic Resonance Imaging and Photodynamic Therapy , 2011 .
[101] Zongxi Li,et al. Aspect ratio determines the quantity of mesoporous silica nanoparticle uptake by a small GTPase-dependent macropinocytosis mechanism. , 2011, ACS nano.
[102] M. Zachariah,et al. Mesoscale porous silica as drug delivery vehicles: Synthesis, characterization, and pH-sensitive release profiles , 2011 .
[103] Mark B. Carter,et al. The Targeted Delivery of Multicomponent Cargos to Cancer Cells via Nanoporous Particle-Supported Lipid Bilayers , 2011, Nature materials.
[104] Hyesung Jeon,et al. Facile synthesis of monodispersed mesoporous silica nanoparticles with ultralarge pores and their application in gene delivery. , 2011, ACS nano.
[105] Y. Lai,et al. Enhanced Chemotherapy of Cancer Using pH-Sensitive Mesoporous Silica Nanoparticles to Antagonize P-Glycoprotein–Mediated Drug Resistance , 2011, Molecular Cancer Therapeutics.
[106] Yuan Yuan,et al. A magnetic, reversible pH-responsive nanogated ensemble based on Fe3O4 nanoparticles-capped mesoporous silica. , 2011, Biomaterials.
[107] P. Liu,et al. Mesoporous silica nanoparticles end-capped with collagen: redox-responsive nanoreservoirs for targeted drug delivery. , 2011, Angewandte Chemie.
[108] El-Zeiny M. Ebeid,et al. Nanostructure-loaded mesoporous silica for controlled release of coumarin derivatives: a novel testing of the hyperthermia effect. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
[109] Cynthia L. Warner,et al. Functionalized nanoporous silica for the removal of heavy metals from biological systems: adsorption and application. , 2010, ACS applied materials & interfaces.
[110] G. Fryxell,et al. IN VITRO AND IN VIVO EVALUATION OF A NOVEL FERROCYANIDE FUNCTIONALIZED NANOPOUROUS SILICA DECORPORATION AGENT FOR CESIUM IN RATS , 2010, Health physics.
[111] G. Fryxell,et al. FUNCTIONAL SORBENTS FOR SELECTIVE CAPTURE OF PLUTONIUM, AMERICIUM, URANIUM, AND THORIUM IN BLOOD , 2010, Health physics.
[112] S. Bhattarai,et al. Enhanced Gene and siRNA Delivery by Polycation-Modified Mesoporous Silica Nanoparticles Loaded with Chloroquine , 2010, Pharmaceutical Research.
[113] Zongxi Li,et al. Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line. , 2010, ACS nano.
[114] S. Bensamoun,et al. Accelerated Achilles tendon healing by PDGF gene delivery with mesoporous silica nanoparticles. , 2010, Biomaterials.
[115] Zongxi Li,et al. Mesoporous silica nanoparticles facilitate delivery of siRNA to shutdown signaling pathways in mammalian cells. , 2010, Small.
[116] Qianjun He,et al. An anticancer drug delivery system based on surfactant-templated mesoporous silica nanoparticles. , 2010, Biomaterials.
[117] Li Shi,et al. Designer nanoparticles: incorporating size, shape and triggered release into nanoscale drug carriers , 2010, Expert opinion on drug delivery.
[118] M Ferrari,et al. Size and shape effects in the biodistribution of intravascularly injected particles. , 2010, Journal of controlled release : official journal of the Controlled Release Society.
[119] T. Asefa,et al. Mesoporous silica microparticles enhance the cytotoxicity of anticancer platinum drugs. , 2010, ACS nano.
[120] Jide Xu,et al. Novel sorbents for removal of gadolinium-based contrast agents in sorbent dialysis and hemoperfusion: preventive approaches to nephrogenic systemic fibrosis. , 2010, Nanomedicine : nanotechnology, biology, and medicine.
[121] Min Zhang,et al. Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells. , 2009, Small.
[122] N. Ghosh,et al. A review on chemical methodologies for preparation of mesoporous silica and alumina based materials. , 2009, Recent patents on nanotechnology.
[123] Saji George,et al. Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs. , 2009, ACS nano.
[124] V. S. Lin,et al. Mesoporous silica nanoparticle-based double drug delivery system for glucose-responsive controlled release of insulin and cyclic AMP. , 2009, Journal of the American Chemical Society.
[125] S. Tangestaninejad,et al. Alkene epoxidation catalyzed by molybdenum supported on functionalized MCM-41 containing N–S chelating Schiff base ligand , 2009 .
[126] Juan L. Vivero-Escoto,et al. Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers. , 2008, Advanced drug delivery reviews.
[127] Myung-Haing Cho,et al. Mannosylated polyethylenimine coupled mesoporous silica nanoparticles for receptor-mediated gene delivery. , 2008, International journal of pharmaceutics.
[128] Brian G. Trewyn,et al. Biocompatible mesoporous silica nanoparticles with different morphologies for animal cell membrane penetration , 2008 .
[129] Weibo Cai,et al. Nanoplatforms for targeted molecular imaging in living subjects. , 2007, Small.
[130] Monty Liong,et al. Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs. , 2007, Small.
[131] Victor S-Y Lin,et al. A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules. , 2003, Journal of the American Chemical Society.
[132] Natarajan Raghunand,et al. In vivo imaging of extracellular pH using 1H MRSI , 1999, Magnetic resonance in medicine.
[133] J. B. Higgins,et al. A new family of mesoporous molecular sieves prepared with liquid crystal templates , 1992 .
[134] I. Tannock,et al. Acid pH in tumors and its potential for therapeutic exploitation. , 1989, Cancer research.