14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites

[1]  B. Kemp,et al.  CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins , 2020, The Journal of Biological Chemistry.

[2]  G. Travé,et al.  Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms , 2021, Nature Communications.

[3]  S. Malek,et al.  Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization , 2020, Nature Structural & Molecular Biology.

[4]  S. Strelkov,et al.  Concatenation of 14-3-3 with partner phosphoproteins as a tool to study their interaction , 2019, Scientific Reports.

[5]  S. Ficarro,et al.  Architecture of autoinhibited and active BRAF/MEK1/14-3-3 complexes , 2019, Nature.

[6]  S. Subramaniam,et al.  Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases , 2019, Science.

[7]  C. Ottmann,et al.  AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins , 2019, The Journal of Biological Chemistry.

[8]  T. Obsil,et al.  14‐3‐3 protein masks the nuclear localization sequence of caspase‐2 , 2018, The FEBS journal.

[9]  T. Obsil,et al.  CaMKK2 kinase domain interacts with the autoinhibitory region through the N-terminal lobe including the RP insert. , 2018, Biochimica et biophysica acta. General subjects.

[10]  T. Obsil,et al.  14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2). , 2018, Biochimica et biophysica acta. General subjects.

[11]  E. Roh,et al.  Death‐associated protein kinase (DAPK) family modulators: Current and future therapeutic outcomes , 2018, Medicinal research reviews.

[12]  Andrea Sinz,et al.  Cross-Linking/Mass Spectrometry for Studying Protein Structures and Protein-Protein Interactions: Where Are We Now and Where Should We Go from Here? , 2018, Angewandte Chemie.

[13]  M. Eisenstein,et al.  Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy , 2018, Nature Communications.

[14]  Dmitri I. Svergun,et al.  CHROMIXS: automatic and interactive analysis of chromatography-coupled small-angle X-ray scattering data , 2017, Bioinform..

[15]  T. Obsil,et al.  Molecular basis of the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1 , 2017, Proceedings of the National Academy of Sciences.

[16]  Thomas J. Simmons,et al.  Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates , 2017, Nature Communications.

[17]  L. M. Stevers,et al.  Modulators of 14-3-3 Protein–Protein Interactions , 2017, Journal of medicinal chemistry.

[18]  M. Nardini,et al.  Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins[OPEN] , 2017, Plant Cell.

[19]  A. Antson,et al.  Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator. , 2017, Structure.

[20]  Zdeněk Tošner,et al.  Structural Insight into the 14-3-3 Protein-dependent Inhibition of Protein Kinase ASK1 (Apoptosis Signal-regulating kinase 1)* , 2016, The Journal of Biological Chemistry.

[21]  D. Svergun,et al.  Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites , 2016, Structure.

[22]  L. M. Stevers,et al.  Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR , 2016, Proceedings of the National Academy of Sciences.

[23]  A. Tsuji,et al.  Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins. , 2015, Biochemical and biophysical research communications.

[24]  A. Kimchi,et al.  DAPK2 is a novel regulator of mTORC1 activity and autophagy , 2014, Cell Death and Differentiation.

[25]  A. Kimchi,et al.  Discovering protein-protein interactions within the programmed cell death network using a protein-fragment complementation screen. , 2014, Cell reports.

[26]  Michele Tinti,et al.  ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome , 2014, Database J. Biol. Databases Curation.

[27]  H. Simon,et al.  DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants , 2014, Journal of leukocyte biology.

[28]  A. Kimchi,et al.  The DAPK family: a structure–function analysis , 2014, Apoptosis.

[29]  C. Ottmann,et al.  A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. , 2013, Chemistry & biology.

[30]  John Kuriyan,et al.  Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II. , 2013, Current opinion in structural biology.

[31]  C. Ottmann,et al.  Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI. , 2012, Journal of structural biology.

[32]  A. Tsuji,et al.  cGMP-dependent protein kinase I promotes cell apoptosis through hyperactivation of death-associated protein kinase 2. , 2012, Biochemical and biophysical research communications.

[33]  Dominique Durand,et al.  How Random are Intrinsically Disordered Proteins? A Small Angle Scattering Perspective , 2012, Current protein & peptide science.

[34]  R. Yadav,et al.  Structure of the dimeric autoinhibited conformation of DAPK2, a pro-apoptotic protein kinase. , 2011, Journal of molecular biology.

[35]  P. Heřman,et al.  Maximum Entropy Analysis of Analytically Simulated Complex Fluorescence Decays , 2011, Journal of Fluorescence.

[36]  J. Teisinger,et al.  Characterization of calmodulin binding domains in TRPV2 and TRPV5 C-tails , 2011, Amino Acids.

[37]  C. Der Faculty Opinions recommendation of COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. , 2010 .

[38]  C. Ottmann,et al.  Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling , 2010, Molecular and Cellular Biology.

[39]  Peter J Parker,et al.  Recognition of an intra‐chain tandem 14‐3‐3 binding site within PKCε , 2009, EMBO reports.

[40]  Gernot Jäger,et al.  Targeted Restoration of Down-regulated DAPK2 Tumor Suppressor Activity Induces Apoptosis in Hodgkin Lymphoma Cells , 2009, Journal of immunotherapy.

[41]  Dmitri I. Svergun,et al.  Electronic Reprint Applied Crystallography Dammif, a Program for Rapid Ab-initio Shape Determination in Small-angle Scattering Applied Crystallography Dammif, a Program for Rapid Ab-initio Shape Determination in Small-angle Scattering , 2022 .

[42]  M. Erdoğan,et al.  Down-regulation of Death-associated Protein Kinase-2 Is Required for β-Catenin-induced Anoikis Resistance of Malignant Epithelial Cells* , 2009, Journal of Biological Chemistry.

[43]  M. Tschan,et al.  DAPK2 is a novel E2F1/KLF6 target gene involved in their proapoptotic function , 2008, Oncogene.

[44]  F. Niesen,et al.  The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability , 2007, Nature Protocols.

[45]  B. Torbett,et al.  The death‐associated protein kinase 2 is up‐regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells , 2007, Journal of leukocyte biology.

[46]  A. Kimchi,et al.  The death-associated protein kinases: structure, function, and beyond. , 2006, Annual review of biochemistry.

[47]  L. Amzel,et al.  C-terminal Recognition by 14-3-3 Proteins for Surface Expression of Membrane Receptors* , 2005, Journal of Biological Chemistry.

[48]  D. Klein,et al.  Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[49]  T. Soderling,et al.  Inhibition of Calcium/Calmodulin-dependent Protein Kinase Kinase by Protein 14-3-3* , 2004, Journal of Biological Chemistry.

[50]  Dmitri I. Svergun,et al.  PRIMUS: a Windows PC-based system for small-angle scattering data analysis , 2003 .

[51]  Dmitri I. Svergun,et al.  Uniqueness of ab initio shape determination in small-angle scattering , 2003 .

[52]  Martin Würtele,et al.  Structural view of a fungal toxin acting on a 14‐3‐3 regulatory complex , 2003, The EMBO journal.

[53]  A. Kimchi,et al.  DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death , 2002, The Journal of cell biology.

[54]  M. Eisenstein,et al.  The Pro-apoptotic Function of Death-associated Protein Kinase Is Controlled by a Unique Inhibitory Autophosphorylation-based Mechanism* , 2001, The Journal of Biological Chemistry.

[55]  R. Ghirlando,et al.  Crystal Structure of the 14-3-3ζ:Serotonin N-Acetyltransferase Complex A Role for Scaffolding in Enzyme Regulation , 2001, Cell.

[56]  K. Scheidtmann,et al.  The DAP kinase family of pro‐apoptotic proteins: novel players in the apoptotic game , 2001, BioEssays : news and reviews in molecular, cellular and developmental biology.

[57]  M Eisenstein,et al.  Autophosphorylation restrains the apoptotic activity of DRP‐1 kinase by controlling dimerization and calmodulin binding , 2001, The EMBO journal.

[58]  Dmitri I. Svergun,et al.  Automated matching of high- and low-resolution structural models , 2001 .

[59]  A. Kimchi,et al.  Death-Associated Protein Kinase-Related Protein 1, a Novel Serine/Threonine Kinase Involved in Apoptosis , 2000, Molecular and Cellular Biology.

[60]  S. Akira,et al.  Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity , 1999, Oncogene.

[61]  A. Nairn,et al.  Inhibition of the Ca2+/Calmodulin-dependent Protein Kinase I Cascade by cAMP-dependent Protein Kinase* , 1999, The Journal of Biological Chemistry.

[62]  S. Akira,et al.  DRAKs, Novel Serine/Threonine Kinases Related to Death-associated Protein Kinase That Trigger Apoptosis* , 1998, The Journal of Biological Chemistry.

[63]  Shizuo Akira,et al.  ZIP Kinase, a Novel Serine/Threonine Kinase Which Mediates Apoptosis , 1998, Molecular and Cellular Biology.

[64]  M. Yaffe,et al.  The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity , 1997, Cell.

[65]  A. Vagin,et al.  MOLREP: an Automated Program for Molecular Replacement , 1997 .

[66]  Dmitri I. Svergun,et al.  Determination of the regularization parameter in indirect-transform methods using perceptual criteria , 1992 .

[67]  R. Bryan,et al.  Maximum entropy analysis of oversampled data problems , 1990, European Biophysics Journal.

[68]  R. Kincaid,et al.  Ca2+-dependent interaction of 5-dimethylaminonaphthalene-1-sulfonyl-calmodulin with cyclic nucleotide phosphodiesterase, calcineurin, and troponin I. , 1982, The Journal of biological chemistry.

[69]  P. Boston,et al.  Human 14‐3‐3 Protein: Radioimmunoassay, Tissue Distribution, and Cerebrospinal Fluid Levels in Patients with Neurological Disorders , 1982, Journal of neurochemistry.

[70]  P. Jackson,et al.  Purification, Properties, and Immunohistochemical Localisation of Human Brain 14‐3‐3 Protein , 1982, Journal of Neurochemistry.

[71]  N. Sluchanko,et al.  Intrinsic disorder associated with 14-3-3 proteins and their partners. , 2019, Progress in molecular biology and translational science.

[72]  D. Svergun,et al.  Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering. , 2012, Molecular bioSystems.

[73]  A. D. de Boer,et al.  Fusicoccanes: diterpenes with surprising biological functions. , 2012, Trends in plant science.

[74]  Vincent B. Chen,et al.  Acta Crystallographica Section D Biological , 2001 .