Philadelphia‐chromosome‐negative chronic myelogenous leukemia with lymphoid stem cell blastic transformation

A patient is described who had blastic transformation of Ph1 negative chronic myelogenous leukemia (Ph1 – CML). Characterization of the leukemic cells revealed a population with a lymphoid stem cell phenotype (cALL–, TdT +, Ia+, cIgM –). This particular phenotype may be responsible for the refractoriness to vincristine and prednisone and the rapid downhill course.

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