Development of a novel signature derived from single cell RNA‐sequencing for preoperative prediction of lymph node metastasis in head and neck squamous cell carcinoma

Lymph node metastasis (LNM) is considered as an adverse prognostic indicator for cancer patients. Preoperative knowledge of LNM is valuable for pretreatment decision making. Here, we sought to develop and validate an LNM signature for preoperative prediction of LNM in patients with head and neck squamous cell carcinoma (HNSCC).

[1]  Pengfei Diao,et al.  Immune landscape and subtypes in primary resectable oral squamous cell carcinoma: prognostic significance and predictive of therapeutic response , 2021, Journal for ImmunoTherapy of Cancer.

[2]  I. Tirosh,et al.  Single-Cell Deconvolution of Head and Neck Squamous Cell Carcinoma , 2021, Cancers.

[3]  Huan Li,et al.  Single‐cell transcriptomics reveal the intratumoral landscape of infiltrated T‐cell subpopulations in oral squamous cell carcinoma , 2021, Molecular oncology.

[4]  C. R. Leemans,et al.  Head and neck squamous cell carcinoma , 2020, Nature Reviews Disease Primers.

[5]  I. Tirosh,et al.  Malignant cell-specific CXCL14 promotes tumor lymphocyte infiltration in oral cavity squamous cell carcinoma , 2020, Journal for ImmunoTherapy of Cancer.

[6]  Aviv Regev,et al.  A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors , 2019, Nature Medicine.

[7]  Jiashuo Wang,et al.  A Pre-operative Nomogram for Prediction of Lymph Node Metastasis in Bladder Urothelial Carcinoma , 2019, Front. Oncol..

[8]  R. Ferris,et al.  The changing therapeutic landscape of head and neck cancer , 2019, Nature Reviews Clinical Oncology.

[9]  Pengfei Diao,et al.  Identification of 4‐lncRNA prognostic signature in head and neck squamous cell carcinoma , 2018, Journal of cellular biochemistry.

[10]  A. Jemal,et al.  Cancer statistics, 2019 , 2019, CA: a cancer journal for clinicians.

[11]  Shawn M. Gillespie,et al.  Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer , 2017, Cell.

[12]  Yarden Katz,et al.  A single-cell survey of the small intestinal epithelium , 2017, Nature.

[13]  Brian O'Sullivan,et al.  Head and neck cancers—major changes in the American Joint Committee on cancer eighth edition cancer staging manual , 2017, CA: a cancer journal for clinicians.

[14]  A. Regev,et al.  Scaling single-cell genomics from phenomenology to mechanism , 2017, Nature.

[15]  Mariella G. Filbin,et al.  Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma , 2016, Nature.

[16]  Yanqi Huang,et al.  Development and Validation of a Radiomics Nomogram for Preoperative Prediction of Lymph Node Metastasis in Colorectal Cancer. , 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[17]  A. Jemal,et al.  Cancer treatment and survivorship statistics, 2016 , 2016, CA: a cancer journal for clinicians.

[18]  D. Nam,et al.  Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma , 2016, Genome Biology.

[19]  Charles H. Yoon,et al.  Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq , 2016, Science.

[20]  M. Scholz,et al.  The role of HPV RNA transcription, immune response‐related gene expression and disruptive TP53 mutations in diagnostic and prognostic profiling of head and neck cancer , 2015, International journal of cancer.

[21]  N. Navin,et al.  The first five years of single-cell cancer genomics and beyond , 2015, Genome research.

[22]  M. Charoenpitakchai,et al.  Prognostic factors of cervical node status in head and neck squamous cell carcinoma , 2015, World Journal of Surgical Oncology.

[23]  S. Hung,et al.  Computed tomography image characteristics of metastatic lymph nodes in patients with squamous cell carcinoma of the head and neck. , 2012, Auris, nasus, larynx.

[24]  Seiji Nakamura,et al.  Clinical significance of combined assessment of the maximum standardized uptake value of F-18 FDG PET with nodal size in the diagnosis of cervical lymph node metastasis of oral squamous cell carcinoma. , 2012, Academic radiology.

[25]  K. Yuasa,et al.  Quantitative evaluation of vascularity within cervical lymph nodes using Doppler ultrasound in patients with oral cancer: relation to lymph node size. , 2011, Dento maxillo facial radiology.

[26]  P. Hofman,et al.  Morphological MRI criteria improve the detection of lymph node metastases in head and neck squamous cell carcinoma: multivariate logistic regression analysis of MRI features of cervical lymph nodes , 2008, European Radiology.

[27]  N. Tamaki,et al.  Assessment of cervical lymph node metastases using FDG-PET in patients with head and neck cancer , 2008, Annals of nuclear medicine.

[28]  Cheng Li,et al.  Adjusting batch effects in microarray expression data using empirical Bayes methods. , 2007, Biostatistics.

[29]  T. Link,et al.  Comparison of 16-slice MSCT and MRI in the assessment of squamous cell carcinoma of the oral cavity. , 2006, European journal of radiology.

[30]  J. Shah,et al.  TNM Staging of Cancers of the Head and Neck: Striving for Uniformity Among Diversity , 2005, CA: a cancer journal for clinicians.

[31]  R. Takes.  Staging of the neck in patients with head and neck squamous cell cancer: imaging techniques and biomarkers. , 2004, Oral oncology.

[32]  Ruud H. Brakenhoff,et al.  Dissecting the metastatic cascade , 2004, Nature Reviews Cancer.

[33]  S. Taylor.  Head and neck cancer. , 1991, Cancer chemotherapy and biological response modifiers.