Increased IL‐6 and Potential IL‐6 trans‐signalling in the airways after an allergen challenge

In asthma, IL‐6 is a potential cause of enhanced inflammation, tissue damage and airway dysfunction. IL‐6 signalling is regulated by its receptor, which is composed of two proteins, IL‐6R and GP130. In addition to their membrane form, these two proteins may be found as extracellular soluble forms. The interaction of IL‐6 with soluble IL‐6R (sIL‐6R) can trigger IL‐6 trans‐signalling in cells lacking IL‐6R. Conversely, the soluble form of GP130 (sGP130) competes with its membrane form to inhibit IL‐6 trans‐signalling.

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