Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer

Recent publications have classified breast cancers on the basis of expression of cytokeratin-5 and -17 at the RNA and protein levels, and demonstrated the importance of these markers in defining sporadic tumours with bad prognosis and an association with BRCA1-related breast cancers. These important observations using different technology platforms produce a new functional classification of breast carcinoma. However, it is important in developing hypotheses about the pathogenesis of this tumour type to review the nomenclature that is being used to emphasize potential confusion between terminology that defines clinical subgroups and markers of cell lineage. This article reviews the lineages in the normal breast in relation to what have become known as the 'basal-like' carcinomas.

[1]  H M Jensen,et al.  An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions. , 1975, Journal of the National Cancer Institute.

[2]  J. Rice,et al.  Preneoplastic lesions in the human breast. , 1976, Science.

[3]  R. F. Harvey,et al.  A SIMPLE INDEX OF CROHN'S-DISEASE ACTIVITY , 1980, The Lancet.

[4]  S. Wellings,et al.  A hypothesis of the origin of human breast cancer from the terminal ductal lobular unit. , 1980, Pathology, research and practice.

[5]  B. Gusterson,et al.  Distribution of myoepithelial cells and basement membrane proteins in the normal breast and in benign and malignant breast diseases. , 1982, Cancer research.

[6]  Benjamin Geiger,et al.  The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells , 1982, Cell.

[7]  R. Moll,et al.  Complex cytokeratin polypeptide patterns observed in certain human carcinomas. , 1982, Differentiation; research in biological diversity.

[8]  A. Ben-Ze'ev,et al.  Cell density and cell shape-related regulation of vimentin and cytokeratin synthesis. Inhibition of vimentin synthesis and appearance of a new 45 kD cytokeratin in dense epithelial cell cultures. , 1985, Experimental cell research.

[9]  B. Gusterson,et al.  Identification of myoepithelial cells in human and rat breasts by anti-common acute lymphoblastic leukemia antigen antibody A12. , 1986, Journal of the National Cancer Institute.

[10]  R. Nagle,et al.  Characterization of breast carcinomas by two monoclonal antibodies distinguishing myoepithelial from luminal epithelial cells. , 1986, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[11]  A. Hackett,et al.  MONOCLONAL MARKER THAT PREDICTS EARLY RECURRENCE OF BREAST CANCER , 1987, The Lancet.

[12]  R. Nagle,et al.  Differential diagnosis of benign epithelial proliferations and carcinomas of the breast using antibodies to cytokeratins. , 1988, Human pathology.

[13]  E. Lane,et al.  Keratin expression in human mammary epithelial cells cultured from normal and malignant tissue: relation to in vivo phenotypes and influence of medium. , 1989, Journal of cell science.

[14]  R. Nagle.  Intermediate filaments. Efficacy in surgical pathologic diagnosis. , 1989, American journal of clinical pathology.

[15]  D. Roop,et al.  Differential keratin gene expression in developing, differentiating, preneoplastic, and neoplastic mouse mammary epithelium. , 1990, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[16]  E. Lane,et al.  Characterization in vitro of luminal and myoepithelial cells isolated from the human mammary gland by cell sorting. , 1991, Differentiation; research in biological diversity.

[17]  E. Lane,et al.  Basal cell-specific and hyperproliferation-related keratins in human breast cancer. , 1991, The American journal of pathology.

[18]  E. Lane,et al.  Expression of cytokeratin messenger RNA versus protein in the normal mammary gland and in breast cancer. , 1996, Human pathology.

[19]  Yong-jie Lu,et al.  Experimental pathology and breast cancer genetics: new technologies. , 1998, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[20]  R. Moll,et al.  Biological and prognostic significance of stratified epithelial cytokeratins in infiltrating ductal breast carcinomas , 1998, Virchows Archiv.

[21]  E. Lane,et al.  The development of epithelial phenotypes in the human fetal and infant breast , 1998, The Journal of pathology.

[22]  M J O'Hare,et al.  Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[23]  M. Bissell,et al.  Human mammary luminal epithelial cells contain progenitors to myoepithelial cells. , 1999, Developmental biology.

[24]  Christian A. Rees,et al.  Molecular portraits of human breast tumours , 2000, Nature.

[25]  T. Tot.  The cytokeratin profile of medullary carcinoma of the breast , 2000, Histopathology.

[26]  A. Bankfalvi,et al.  Cytokeratin 5/6 immunohistochemistry assists the differential diagnosis of atypical proliferations of the breast , 2000, Histopathology.

[27]  S. Lakhani,et al.  CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation , 2001, British Journal of Cancer.

[28]  R. Tibshirani,et al.  Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[29]  K. Schaefer,et al.  Monoclonality in normal epithelium and in hyperplastic and neoplastic lesions of the breast , 2001, The Journal of pathology.

[30]  Charles M. Perou,et al.  A Comparison of Gene Expression Signatures from Breast Tumors and Breast Tissue Derived Cell Lines , 2002, Disease markers.

[31]  Hermann Herbst,et al.  Common Adult Stem Cells in the Human Breast Give Rise to Glandular and Myoepithelial Cell Lineages: A New Cell Biological Concept , 2002, Laboratory Investigation.

[32]  Martin Eisenacher,et al.  Cytogenetic Alterations and Cytokeratin Expression Patterns in Breast Cancer: Integrating a New Model of Breast Differentiation into Cytogenetic Pathways of Breast Carcinogenesis , 2002, Laboratory Investigation.

[33]  R. Tibshirani,et al.  Copyright © American Society for Investigative Pathology Short Communication Expression of Cytokeratins 17 and 5 Identifies a Group of Breast Carcinomas with Poor Clinical Outcome , 2022 .

[34]  A. Ashworth,et al.  Functional and molecular characterisation of mammary side population cells , 2002, Breast Cancer Research.

[35]  C. Perou,et al.  Molecular portraits and the family tree of cancer , 2002, Nature Genetics.

[36]  T. Graubert,et al.  Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population. , 2002, Developmental biology.

[37]  One,et al.  Epithelial progenitor cell lines as models of normal breast morphogenesis and neoplasia , 2003 .

[38]  Philip M. Long,et al.  Breast cancer classification and prognosis based on gene expression profiles from a population-based study , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[39]  L. Bégin,et al.  Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer. , 2004, Journal of the National Cancer Institute.

[40]  W. Boecker,et al.  Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium: a new progenitor (adult stem) cell concept , 2003, Cell proliferation.

[41]  R. Tibshirani,et al.  Repeated observation of breast tumor subtypes in independent gene expression data sets , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[42]  M. Bissell,et al.  Epithelial progenitor cell lines as models of normal breast morphogenesis and neoplasia , 2003, Cell proliferation.

[43]  J. Reis-Filho,et al.  Novel and Classic Myoepithelial/Stem Cell Markers in Metaplastic Carcinomas of the Breast , 2003, Applied immunohistochemistry & molecular morphology : AIMM.

[44]  Novel and classic myoepithelial/stem cell markers in metaplastic carcinomas of the breast , 2003 .

[45]  J. Dering,et al.  Recent translational research: microarray expression profiling of breast cancer – beyond classification and prognostic markers? , 2004, Breast Cancer Research.

[46]  A. Gown,et al.  Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma , 2004, Clinical Cancer Research.

[47]  W. Foulkes.  BRCA1 functions as a breast stem cell regulator , 2004, Journal of Medical Genetics.

[48]  William D. Foulkes,et al.  Re: Germline BRCA1 Mutations and a Basal Epithelial Phenotype in Breast Cancer , 2004 .

[49]  C. Perou,et al.  Cell-Type-Specific Responses to Chemotherapeutics in Breast Cancer , 2004, Cancer Research.

[50]  David Botstein,et al.  Different gene expression patterns in invasive lobular and ductal carcinomas of the breast. , 2004, Molecular biology of the cell.

[51]  C. Perou,et al.  Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression. , 2004, Cancer cell.

[52]  Jorge S. Reis-Filho,et al.  Molecular Cytogenetic Identification of Subgroups of Grade III Invasive Ductal Breast Carcinomas with Different Clinical Outcomes , 2004, Clinical Cancer Research.

[53]  G. Dontu,et al.  Breast cancer, stem/progenitor cells and the estrogen receptor , 2004, Trends in Endocrinology & Metabolism.

[54]  I. Ellis,et al.  Expression of luminal and basal cytokeratins in human breast carcinoma , 2004, The Journal of pathology.

[55]  M. Vivanco,et al.  Growth and differentiation of progenitor/stem cells derived from the human mammary gland. , 2004, Experimental cell research.

[56]  A. Howell,et al.  A putative human breast stem cell population is enriched for steroid receptor-positive cells. , 2005, Developmental biology.

[57]  Fariba Behbod,et al.  Will cancer stem cells provide new therapeutic targets? , 2005, Carcinogenesis.

[58]  S. Lakhani,et al.  Molecular evolution of breast cancer , 2005, The Journal of pathology.