Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy.

[1]  G. Koehl,et al.  Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor , 2002, Nature Medicine.

[2]  J. Cherrington,et al.  The Antiangiogenic Agents SU5416 and SU6668 Increase the Antitumor Effects of Fractionated Irradiation , 2002, Radiation research.

[3]  D. Fabbro,et al.  Effect of VEGF receptor inhibitor PTK787/ZK222548 combined with ionizing radiation on endothelial cells and tumour growth , 2001, British Journal of Cancer.

[4]  J. Camardo,et al.  Rapamycin: clinical results and future opportunities. , 2001, Transplantation.

[5]  P. Harari,et al.  Radiation response modification following molecular inhibition of epidermal growth factor receptor signaling. , 2001, Seminars in radiation oncology.

[6]  R. DePinho,et al.  Malignant glioma: genetics and biology of a grave matter. , 2001, Genes & development.

[7]  A. Gingras,et al.  Regulation of translation initiation by FRAP/mTOR. , 2001, Genes & development.

[8]  D. Hallahan,et al.  Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy. , 2001, Cancer research.

[9]  D. O’Rourke,et al.  Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia. , 2000, Cancer research.

[10]  J. Fowler,et al.  Confirmation of improved local-regional control with altered fractionation in head and neck cancer. , 2000, International journal of radiation oncology, biology, physics.

[11]  H. Withers,et al.  Transmutability of dose and time. Commentary on the first report of RTOG 90003 (K. K. FU et al.) , 2000, International journal of radiation oncology, biology, physics.

[12]  Christine C. Hudson,et al.  A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. , 2000, Cancer research.

[13]  Eric C. Holland,et al.  Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice , 2000, Nature Genetics.

[14]  C. James,et al.  Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. , 2000, Cancer research.

[15]  A. Koong,et al.  Loss of PTEN facilitates HIF-1-mediated gene expression. , 2000, Genes & development.

[16]  H. Hwang,et al.  Radiosensitivity of thymidylate synthase-deficient human tumor cells is affected by progression through the G1 restriction point into S-phase: implications for fluoropyrimidine radiosensitization. , 2000, Cancer research.

[17]  S. Schreiber,et al.  Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[18]  R. Dale,et al.  Inclusion of molecular biotherapies with radical radiotherapy: modeling of combined modality treatment schedules. , 1999, International journal of radiation oncology, biology, physics.

[19]  T. Seufferlein,et al.  Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells. , 1999, Cancer research.

[20]  R. Weichselbaum,et al.  Blockade of the Vascular Endothelial Growth Factor Stress Response Increases the Antitumor Effects of Ionizing Radiation , 1999 .

[21]  A. Merlo,et al.  Frequent Co‐Alterations of TP53, p16/CDKN2A, p14ARF, PTEN Tumor Suppressor Genes in Human Glioma Cell Lines. , 1999, Brain pathology.

[22]  Linda N. Liu,et al.  Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells. , 1999, Cancer research.

[23]  Gordon Mills,et al.  Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC , 1998, Current Biology.

[24]  S. Desrivières,et al.  Rapamycin Inhibition of the G1 to S Transition Is Mediated by Effects on Cyclin D1 mRNA and Protein Stability* , 1998, The Journal of Biological Chemistry.

[25]  R E Durand,et al.  Cell kinetics and repopulation mechanisms during multifraction irradiation of spheroids. , 1998, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[26]  A. Giaccia,et al.  Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. , 1997, Blood.

[27]  K. Rosenzweig,et al.  Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

[28]  L Meijer,et al.  Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. , 1997, European journal of biochemistry.

[29]  J. Massagué,et al.  Rapamycin resistance tied to defective regulation of p27Kip1 , 1996, Molecular and cellular biology.

[30]  A. Taghian,et al.  In vivo radiation sensitivity of glioblastoma multiforme. , 1995, International journal of radiation oncology, biology, physics.

[31]  M. Lindstrom,et al.  The decreased influence of overall treatment time on the response of human breast tumor xenografts following prolongation of the potential doubling time (Tpot). , 1995, International journal of radiation oncology, biology, physics.

[32]  Charles B. Wilson,et al.  Correlation between the bromodeoxyuridine labeling index and the MIB‐1 and Ki‐67 proliferating cell indices in cerebral gliomas , 1994, Cancer.

[33]  Paul Tempst,et al.  RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs , 1994, Cell.

[34]  Stuart L. Schreiber,et al.  A mammalian protein targeted by G1-arresting rapamycin–receptor complex , 1994, Nature.

[35]  P. Workman,et al.  Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors. , 1994, International journal of radiation oncology, biology, physics.

[36]  M. Lindstrom,et al.  Tamoxifen-induced increase in the potential doubling time of MCF-7 xenografts as determined by bromodeoxyuridine labeling and flow cytometry. , 1993, Cancer research.

[37]  M. Lindstrom,et al.  Loss of local control with prolongation in radiotherapy. , 1992, International journal of radiation oncology, biology, physics.

[38]  C. Daumas-Duport,et al.  Histological grading and bromodeoxyuridine labeling index of astrocytomas. Comparative study in a series of 60 cases. , 1991, Journal of neurosurgery.

[39]  A. Zietman,et al.  Radiation response of xenografts of a human squamous cell carcinoma and a glioblastoma multiforme: a progress report. , 1990, International journal of radiation oncology, biology, physics.

[40]  R. Sutherland Cell and environment interactions in tumor microregions: the multicell spheroid model. , 1988, Science.

[41]  J. Peacock,et al.  Radiation cell survival and growth delay studies in multicellular spheroids of small-cell lung carcinoma. , 1987, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[42]  G. Hahn,et al.  Repair of potentially lethal radiation damage in vitro and in vivo. , 1973, Radiology.