Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis

[1]  S. Hauser,et al.  Identification of autoantibodies associated with myelin damage in multiple sclerosis , 1999, Nature Medicine.

[2]  H. Alder,et al.  Oxidative damage to DNA in plaques of MS brains , 1998, Multiple sclerosis.

[3]  R. Schmidt,et al.  Peroxynitrite formation within the central nervous system in active multiple sclerosis , 1998, Journal of Neuroimmunology.

[4]  R. Rudick,et al.  Axonal transection in the lesions of multiple sclerosis. , 1998, The New England journal of medicine.

[5]  P M Matthews,et al.  Imaging axonal damage of normal-appearing white matter in multiple sclerosis. , 1998, Brain : a journal of neurology.

[6]  A. Cross,et al.  Evidence for the production of peroxynitrite in inflammatory CNS demyelination , 1997, Journal of Neuroimmunology.

[7]  G. Barker,et al.  1H magnetic resonance spectroscopy of chronic cerebral white matter lesions and normal appearing white matter in multiple sclerosis , 1997, Journal of neurology, neurosurgery, and psychiatry.

[8]  Hans Lassmann,et al.  Inflammatory central nervous system demyelination: Correlation of magnetic resonance imaging findings with lesion pathology , 1997, Annals of neurology.

[9]  G. Holmquist,et al.  Mapping frequencies of endogenous oxidative damage and the kinetic response to oxidative stress in a region of rat mtDNA. , 1997, Nucleic acids research.

[10]  M. Beal,et al.  Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia , 1997, Annals of neurology.

[11]  M. Gurney,et al.  Oxidative stress, mutant SOD1, and neurofilament pathology in transgenic mouse models of human motor neuron disease. , 1997, Laboratory investigation; a journal of technical methods and pathology.

[12]  V. Perry,et al.  Axonal damage in acute multiple sclerosis lesions. , 1997, Brain : a journal of neurology.

[13]  F. Barkhof,et al.  Accumulation of hypointense lesions ("black holes") on T1 spin-echo MRI correlates with disease progression in multiple sclerosis , 1996, Neurology.

[14]  R. Santella,et al.  Immunoperoxidase detection of 8-hydroxydeoxyguanosine in aflatoxin B1-treated rat liver and human oral mucosal cells. , 1996, Cancer research.

[15]  T. Olsson,et al.  Augmented expression of tumour necrosis factor-alpha and lymphotoxin in mononuclear cells in multiple sclerosis and optic neuritis. , 1996, Brain : a journal of neurology.

[16]  O. Bagasra,et al.  Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[17]  P. Matthews,et al.  Chemical pathology of acute demyelinating lesions and its correlation with disability , 1995, Annals of neurology.

[18]  D. Hafler,et al.  Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions , 1995, The Journal of experimental medicine.

[19]  M. Beal,et al.  Aging, energy, and oxidative stress in neurodegenerative diseases , 1995, Annals of neurology.

[20]  M. Beal,et al.  Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease , 1994, Journal of neurochemistry.

[21]  D. Hanley,et al.  Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains , 1994, Annals of neurology.

[22]  Patrizia Mecocci,et al.  Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease , 1994, Annals of neurology.

[23]  G. Fein,et al.  Biochemical alterations in multiple sclerosis lesions and normal‐appearing white matter detected by in vivo 31P and 1H spectroscopic imaging , 1994, Annals of neurology.

[24]  D. Turnbull,et al.  An evaluation of the measurement of the activities of complexes I-IV in the respiratory chain of human skeletal muscle mitochondria. , 1994, Biochemical medicine and metabolic biology.

[25]  P. Mecocci,et al.  Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain , 1993, Annals of neurology.

[26]  L. Ignarro,et al.  Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. , 1993, Journal of immunology.

[27]  B. Crain,et al.  Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients. , 1993, Genomics.

[28]  G. Pfeifer,et al.  Detection of DNA adducts at the DNA sequence level by ligation-mediated PCR. , 1993, Mutation research.

[29]  S. Tsang,et al.  5 – Small-Scale Preparation of Skeletal Muscle Mitochondria and Its Application in the Study of Human Disease , 1993 .

[30]  G. Grau,et al.  Tumor necrosis factor alpha production as a possible predictor of relapse in patients with multiple sclerosis. , 1992, European cytokine network.

[31]  G. Davies-Jones,et al.  MR imaging in acute multiple sclerosis: ringlike appearance in plaques suggesting the presence of paramagnetic free radicals. , 1992, AJNR. American journal of neuroradiology.

[32]  J. Nobrega,et al.  Brain Cytochrome Oxidase in Alzheimer's Disease , 1992, Journal of neurochemistry.

[33]  Seung U. Kim,et al.  Oligodendroglial cell death induced by oxygen radicals and its protection by catalase , 1991, Journal of neuroscience research.

[34]  C. Brosnan,et al.  Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. , 1991, The Journal of clinical investigation.

[35]  A. Riggs,et al.  In vivo mapping of a DNA adduct at nucleotide resolution: detection of pyrimidine (6-4) pyrimidone photoproducts by ligation-mediated polymerase chain reaction. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[36]  C. Marsden,et al.  Anatomic and Disease Specificity of NADH CoQ1 Reductase (Complex I) Deficiency in Parkinson's Disease , 1990, Journal of neurochemistry.

[37]  S. Hauser,et al.  Cytokine accumulations in CSF of multiple sclerosis patients , 1990, Neurology.

[38]  C. Marsden,et al.  Mitochondrial Complex I Deficiency in Parkinson's Disease , 1990, Lancet.

[39]  H. Kirchner,et al.  Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations? , 1988, Acta neurologica Scandinavica.

[40]  K. Selmaj,et al.  Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro , 1988, Annals of neurology.

[41]  H. Hopf,et al.  Monocytes constitute the only peripheral blood cell population showing an increased burst activity in multiple sclerosis patients. , 1986, International archives of allergy and applied immunology.

[42]  R. Wiggins,et al.  Effect of Reactive Oxygen Species on Myelin Membrane Proteins , 1985, Journal of neurochemistry.

[43]  A. Lehninger,et al.  Deficiency of the iron-sulfur clusters of mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone oxidoreductase (complex I) in an infant with congenital lactic acidosis. , 1984, The Journal of clinical investigation.

[44]  J. Golaz,et al.  Activated T lymphocytes in patients with multiple sclerosis , 1983, Neurology.

[45]  T. Singer Determination of the activity of succinate, NADH, choline, and alpha-glycerophosphate dehydrogenases. , 2006, Methods of biochemical analysis.