Antioxidant and Antityrosinase Activity of Cissus quadrangularis Extract

The effects of Cissus quadrangularis Linn. extract on antioxidation and tyrosinase inhibition were investigated. The extract showed anti-oxidative activity with an IC50 value of 522.0 μg/mL, and inhibitory effects on tyrosinase activity and melanin production in B16 melanocytes in a dose-dependent manner (100-2000 μg/mL). This study suggests that this species contains anti-tyrosinase components.

[1]  S. Ross.  Metabolic Syndrome: A Proprietary Extract of Cissus quadrangularis Formulation in the Management of Metabolic Syndrome, Weight Loss, and Central Obesity , 2012, Holistic nursing practice.

[2]  G. Mishra,et al.  Pharmacological and therapeutic activity of Cissus quadrangularis: an overview. , 2010 .

[3]  B. Gilchrest,et al.  Cellular mechanisms regulating human melanogenesis , 2009, Cellular and Molecular Life Sciences.

[4]  K. Kang,et al.  The anti-melanogenic effect of pycnogenol by its anti-oxidative actions. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[5]  K. Schallreuter,et al.  Regulation of melanogenesis – controversies and new concepts , 2008, Experimental dermatology.

[6]  A. Panthong,et al.  Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn. , 2007, Journal of ethnopharmacology.

[7]  G. Agbor,et al.  The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome , 2006, Lipids in Health and Disease.

[8]  C. Bertolotto,et al.  BMP-2 stimulates tyrosinase gene expression and melanogenesis in differentiated melanocytes. , 2001, Pigment cell research.

[9]  G Yildiz,et al.  Ferrous iron-induced luminol chemiluminescence: a method for hydroxyl radical study. , 1998, Journal of pharmacological and toxicological methods.

[10]  M. Takagi,et al.  Evaluation of antioxidant activity by chemiluminescence. , 1997, Analytical biochemistry.

[11]  M. Kubo,et al.  Studies of cuticle drugs from natural sources. II. Inhibitory effects of Prunus plants on melanin biosynthesis. , 1994, Biological & pharmaceutical bulletin.