Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory

[1]  Jaekwang Kim,et al.  Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms , 2014, Molecules and cells.

[2]  J. Hardy,et al.  Apolipoprotein E in Alzheimer's disease: an update. , 2014, Annual review of neuroscience.

[3]  F. Crawford,et al.  Apolipoprotein E Isoform-Specific Effects on Lipoprotein Receptor Processing , 2014, NeuroMolecular Medicine.

[4]  E. Weeber,et al.  APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease* , 2012, The Journal of Biological Chemistry.

[5]  K. Garai,et al.  Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer’s disease , 2012, Proceedings of the National Academy of Sciences.

[6]  L. D’Adamio,et al.  Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia , 2012, Molecular Neurodegeneration.

[7]  O. Arancio,et al.  β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia , 2012, Molecular Neurodegeneration.

[8]  Yadong Huang,et al.  Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models. , 2011, Biochemical Society transactions.

[9]  E. Snapp,et al.  Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesicles , 2011, Neurobiology of Aging.

[10]  David M Holtzman,et al.  Human Apoe Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance Nih Public Access , 2022 .

[11]  O. Arancio,et al.  APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant , 2011, The EMBO journal.

[12]  H. Arrighi,et al.  Apolipoprotein E ε4 Prevalence in Alzheimer’s Disease Patients Varies across Global Populations: A Systematic Literature Review and Meta-Analysis , 2010, Dementia and Geriatric Cognitive Disorders.

[13]  O. Arancio,et al.  Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits , 2010, Proceedings of the National Academy of Sciences.

[14]  Wei Li,et al.  Memory Deficits Due to Familial British Dementia BRI2 Mutation Are Caused by Loss of BRI2 Function Rather than Amyloidosis , 2010, The Journal of Neuroscience.

[15]  R. Vidal,et al.  Generation and Initial Characterization of FDD Knock In Mice , 2009, PloS one.

[16]  D. Holtzman,et al.  The Role of Apolipoprotein E in Alzheimer's Disease , 2009, Neuron.

[17]  F. Liu,et al.  Human APOE Isoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice , 2009, The Journal of Neuroscience.

[18]  C. Kelche,et al.  Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks , 2008, Behavioural Brain Research.

[19]  E. McGowan,et al.  BRI2 Inhibits Amyloid β-Peptide Precursor Protein Processing by Interfering with the Docking of Secretases to the Substrate , 2008, The Journal of Neuroscience.

[20]  D. Holtzman,et al.  Transport Pathways for Clearance of Human Alzheimer's Amyloid β-Peptide and Apolipoproteins E and J in the Mouse Central Nervous System , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[21]  P. Bosco,et al.  Allele ɛ4 of APOE is a stronger predictor of Alzheimer risk in Sicily than in continental South Italy , 2005, Neuroscience Letters.

[22]  J. Ghiso,et al.  BRI2 Interacts with Amyloid Precursor Protein (APP) and Regulates Amyloid β (Aβ) Production* , 2005, Journal of Biological Chemistry.

[23]  P. Davies,et al.  The Familial Dementia BRI2 Gene Binds the Alzheimer Gene Amyloid-β Precursor Protein and Inhibits Amyloid-β Production* , 2005, Journal of Biological Chemistry.

[24]  C. Kelche,et al.  Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior , 2005, Behavioural Brain Research.

[25]  D. Schmechel,et al.  Marked regional differences of brain human apolipoprotein e expression in targeted replacement mice , 2004, Neuroscience.

[26]  Richard J. Caselli,et al.  Apolipoprotein E ε4 affects new learning in cognitively normal individuals at risk for Alzheimer’s disease , 2003, Neurobiology of Aging.

[27]  F. Pfrieger,et al.  Cholesterol homeostasis and function in neurons of the central nervous system , 2003, Cellular and Molecular Life Sciences CMLS.

[28]  D. Selkoe.  Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease. , 2002, The Journal of clinical investigation.

[29]  G. Plant,et al.  Complement Activation in Chromosome 13 Dementias , 2002, The Journal of Biological Chemistry.

[30]  David A Bennett,et al.  The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period. , 2002, Archives of neurology.

[31]  G. Plant,et al.  Familial Danish Dementia: A Novel Form of Cerebral Amyloidosis Associated with Deposition of Both Amyloid‐Dan and Amyloid‐Beta , 2002, Journal of neuropathology and experimental neurology.

[32]  J. Flory,et al.  Memory performance and the apolipoprotein E polymorphism in a community sample of middle-aged adults. , 2000, American journal of medical genetics.

[33]  F. Panza,et al.  Apolipoprotein E in Southern Italy: protective effect of ε2 allele in early- and late-onset sporadic Alzheimer's disease , 2000, Neuroscience Letters.

[34]  T Bek,et al.  A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[35]  F. Panza,et al.  Decreased frequency of apolipoprotein E ε4 allele from Northern to Southern Europe in Alzheimer's disease patients and centenarians , 1999, Neuroscience Letters.

[36]  Agueda Rostagno,et al.  A stop-codon mutation in the BRI gene associated with familial British dementia , 1999, Nature.

[37]  Masahiko Watanabe,et al.  Apo E structure determines VLDL clearance and atherosclerosis risk in mice. , 1999, The Journal of clinical investigation.

[38]  J. Holton,et al.  Cytoskeletal pathology in familial cerebral amyloid angiopathy (British type) with non-neuritic amyloid plaque formation , 1999, Acta Neuropathologica.

[39]  J. Poirier,et al.  The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease , 1998, Brain Research Reviews.

[40]  K. Marder,et al.  The APOE- (cid:101) 4 Allele and the Risk of Alzheimer Disease Among African Americans, Whites, and Hispanics , 2001 .

[41]  N. Maeda,et al.  Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis* , 1997, The Journal of Biological Chemistry.

[42]  M. Shapiro,et al.  Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein , 1997, Nature.

[43]  John Hardy,et al.  Amyloid, the presenilins and Alzheimer's disease , 1997, Trends in Neurosciences.

[44]  W. Tsai,et al.  Effect of Age, Ethnicity, and Head Injury on the Association between APOE Genotypes and Alzheimer's Disease , 1996, Annals of the New York Academy of Sciences.

[45]  R. Neve,et al.  Age-Dependent Neuronal and Synaptic Degeneration in Mice Transgenic for the C Terminus of the Amyloid Precursor Protein , 1996, The Journal of Neuroscience.

[46]  N Butters,et al.  Episodic memory changes are associated with the APOE- epsilon 4 allele in nondemented older adults , 1995, Neurology.

[47]  D. Pollen,et al.  Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease , 1995, Nature.

[48]  B. Hyman,et al.  Frequency of the apolipoprotein E ε2 allele is diminished in sporadic Alzheimer disease , 1994, Neuroscience Letters.

[49]  A. M. Saunders,et al.  Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease , 1994, Nature Genetics.

[50]  J. Haines,et al.  Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.

[51]  D. Selkoe.  The molecular pathology of Alzheimer's disease , 1991, Neuron.

[52]  G. Plant,et al.  Familial cerebral amyloid angiopathy with nonneuritic amyloid plaque formation. , 1990, Brain : a journal of neurology.

[53]  R. Mahley,et al.  Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. , 1988, Science.

[54]  R. E. Pitas,et al.  Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain. , 1987, The Journal of biological chemistry.

[55]  J. Taylor,et al.  Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. , 1985, The Journal of clinical investigation.

[56]  R. Mahley,et al.  Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms. , 1981, The Journal of biological chemistry.

[57]  J. Breslow,et al.  Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification. , 1981, Biochemistry.

[58]  E. Strömgren,et al.  CATARACT, DEAFNESS, CEREBELLAR ATAXIA, PSYCHOSIS AND DEMENTIA—A NEW SYNDROME , 1970, Acta neurologica Scandinavica.

[59]  C. Worster-Drought,et al.  Familial Presenile Dementia with Spastic Paralysis* , 1933, The Journal of neurology and psychopathology.

[60]  R. Morris.  Neurobiology of Learning and Memory 72 , 2013 .

[61]  V. Narayanaswami,et al.  Apolipoprotein E: from lipid transport to neurobiology. , 2011, Progress in lipid research.

[62]  D. Selkoe.  Alzheimer's disease. , 2011, Cold Spring Harbor perspectives in biology.

[63]  L. D’Adamio,et al.  Increased AβPP processing in familial Danish dementia patients. , 2011, Journal of Alzheimer's disease : JAD.

[64]  T. Miida,et al.  [Lipoproteins and their receptors in the central nervous system]. , 2009, Rinsho byori. The Japanese journal of clinical pathology.

[65]  J. Holton,et al.  Genetic alterations of the BRI2 gene: familial British and Danish dementias. , 2006, Brain pathology.

[66]  P. Bosco,et al.  Allele epsilon 4 of APOE is a stronger predictor of Alzheimer risk in Sicily than in continental South Italy. , 2005, Neuroscience letters.

[67]  P. Davies,et al.  The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production. , 2005, The Journal of biological chemistry.

[68]  J. Ghiso,et al.  BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production. , 2005, The Journal of biological chemistry.

[69]  Sterling C. Johnson,et al.  Apolipoprotein E epsilon 4 affects new learning in cognitively normal individuals at risk for Alzheimer's disease. , 2003, Neurobiology of aging.

[70]  F. Panza,et al.  Apolipoprotein E in Southern Italy: protective effect of epsilon 2 allele in early- and late-onset sporadic Alzheimer's disease. , 2000, Neuroscience letters.

[71]  C. H. Park,et al.  Roles of A beta and carboxyl terminal peptide fragments of amyloid precursor protein in Alzheimer disease. , 2000, Journal of neural transmission. Supplementum.

[72]  B. Hyman,et al.  Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease. , 1994, Neuroscience letters.

[73]  M A Pericak-Vance,et al.  Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. , 1993, Neurology.