The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. Flavor and Extract Manufacturers Association.

[1]  S. Mitchell,et al.  Fate of dipropyl sulphone in rat. , 1995, Xenobiotica; the fate of foreign compounds in biological systems.

[2]  H. Lee,et al.  Genotoxicity of 1,3-dithiane and 1,4-dithiane in the CHO/SCE assay and the Salmonella/microsomal test. , 1994, Mutation research.

[3]  A. Ohta,et al.  Effects of 2,5-dimethylpyrazine on plasma testosterone and polyamines- and acid phosphatase-levels in the rat prostate. , 1994, Biological & pharmaceutical bulletin.

[4]  S. Mitchell,et al.  Fate of dipropyl sulphide and dipropyl sulphoxide in rat. , 1994, Xenobiotica; the fate of foreign compounds in biological systems.

[5]  A. Ohta,et al.  Effects of dimethylpyrazine isomers on reproductive and accessory reproductive organs in male rats. , 1993, Biological & pharmaceutical bulletin.

[6]  R. J. Price,et al.  Effect of treatment with pyrazine and some derivatives on cytochrome P450 and some enzyme activities in rat liver. , 1993, Xenobiotica; the fate of foreign compounds in biological systems.

[7]  D. H. Hutson,et al.  Metabolism in the rat of a model xenobiotic plant metabolite S-benzyl-N-malonyl-L-cysteine. , 1991, Xenobiotica; the fate of foreign compounds in biological systems.

[8]  J. Cashman,et al.  Enantioselective S-oxygenation by flavin-containing and cytochrome P-450 monooxygenases. , 1990, Chemical research in toxicology.

[9]  T. Blake,et al.  The analysis and characterization of isomeric metabolites of temelastine by the combined use of thermospray liquid chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry. , 1989, Biomedical & environmental mass spectrometry.

[10]  J. Gustafsson,et al.  The metabolism of 4,8-DiMeIQx in conventional and germ-free rats. , 1989, Carcinogenesis.

[11]  T. Blake,et al.  Rapid structural analysis of the in vitro and in vivo metabolism of SK & F 95448 by the combined use of thermospray liquid chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry. , 1989, Biomedical & environmental mass spectrometry.

[12]  J. Holme,et al.  Metabolism of the food carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in isolated rat liver cells. , 1989, Carcinogenesis.

[13]  H. Wallin,et al.  Disposition and metabolism of the food mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in rats. , 1989, Carcinogenesis.

[14]  H. Aposhian,et al.  Determination and metabolism of dithiol chelating agents. VI. Isolation and identification of the mixed disulfides of meso-2,3-dimercaptosuccinic acid with L-cysteine in human urine. , 1989, Toxicology and applied pharmacology.

[15]  Y. Moriwaki,et al.  In vitro conversion of pyrazinamide into 5-hydroxypyrazinamide and that of pyrazinoic acid into 5-hydroxypyrazinoic acid by xanthine oxidase from human liver. , 1987, Biochemical pharmacology.

[16]  M. Armstrong,et al.  Relationships among cytotoxicity, lysosomal breakdown, chromosome aberrations, and DNA double-strand breaks. , 1987, Mutation research.

[17]  J. Saavedra,et al.  The metabolism of N-nitrosobis(2-oxopropyl)amine by microsomes and hepatocytes from Fischer 344 rats. , 1987, Carcinogenesis.

[18]  Y. Moriwaki,et al.  5-Hydroxypyrazinamide, a human metabolite of pyrazinamide. , 1987, Biochemical pharmacology.

[19]  L. Whitehouse,et al.  Metabolic disposition of pyrazinamide in the rat: identification of a novel in vivo metabolite common to both rat and human. , 1987, Biopharmaceutics & drug disposition.

[20]  H. Mukhtar,et al.  Cytochrome P-450 dependent metabolism of testosterone in rat skin. , 1987, Biochemical and biophysical research communications.

[21]  B. Lewis,et al.  Identification of ninhydrin-positive caprolactam metabolites in the rat. , 1987, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[22]  M. Novotny,et al.  Adrenal-mediated endogenous metabolites inhibit puberty in female mice. , 1986, Science.

[23]  J. Stofberg,et al.  The consumption ratio of flavouring materials: a mechanism for setting priorities for safety evaluation. , 1985, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[24]  M. Zajac-Kaye,et al.  DNAase I encapsulated in liposomes can induce neoplastic transformation of syrian hamster embryo cells in culture , 1984, Cell.

[25]  E Gocke,et al.  Study of artificial flavouring substances for mutagenicity in the Salmonella/microsome, Basc and micronucleus tests. , 1983, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[26]  J. Bryan,et al.  The origin of 1-(3-pyridyl-N-oxide)ethanol as a metabolite of 3-acetylpyridine. , 1980, Xenobiotica; the fate of foreign compounds in biological systems.

[27]  G. Hawksworth,et al.  Metabolism in the rat of some pyrazine derivatives having flavour importance in foods. , 1975, Xenobiotica; the fate of foreign compounds in biological systems.

[28]  W Bertsch,et al.  Profile of volatile metabolites in urine by gas chromatography-mass spectrometry. , 1973, Analytical chemistry.

[29]  H. Illing,et al.  Mechanism of biosynthesis of thio- -D-glucuronides and thio- -D-glucosides. , 1972, The Biochemical journal.

[30]  R. Buttery,et al.  Synthesis of some 2-methoxy-3-alkylpyrazines with strong bell pepper-like odors , 1970 .

[31]  J. Mcbain,et al.  S-methylation, oxidation, hydroxylation and conjugation of thiophenol in the rat. , 1969, Biochemical pharmacology.

[32]  J. Posternak,et al.  Summaries of toxicological data: Toxicological tests on flavouring matters , 1969 .

[33]  S. Burstein,et al.  Metabolism of dimethyl sulfide, dimethyl sulfoxide, and dimethyl sulfone in the rabbit. , 1966, Archives of biochemistry and biophysics.

[34]  D. Sylvester,et al.  Antiplatelet structure-activity relationship of tetramethylpyrazine. , 1994, Life sciences.

[35]  J. Löliger,et al.  Contribution of coffee aroma constituents to the mutagenicity of coffee. , 1989, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[36]  W. Troni,et al.  Urinary excretion of 2,5-hexanedione and peripheral polyneuropathies workers exposed to hexane. , 1987, Journal of toxicology and environmental health.

[37]  V. Rogiers,et al.  Metabolism of procyclidine in isolated rat hepatocytes. , 1987, Xenobiotica; the fate of foreign compounds in biological systems.

[38]  D. Brusick.  Genotoxic effects in cultured mammalian cells produced by low pH treatment conditions and increased ion concentrations. , 1986, Environmental mutagenesis.

[39]  E. Moran,et al.  Acute oral toxicity of Selected Flavour Chemicals , 1980 .

[40]  W. Powrie,et al.  Mutagenic activity of pyrazine derivatives: a comparative study with Salmonella typhimurium, Saccharomyces cerevisiae and Chinese hamster ovary cells. , 1980, Food and cosmetics toxicology.

[41]  D. Ziegler.  Chapter 9 – Microsomal Flavin-Containing Monooxygenase: Oxygenation of Nucleophilic Nitrogen and Sulfur Compounds , 1980 .

[42]  J. Stell,et al.  The oxidation of azaheterocycles with mammalian liver aldehyde oxidase. , 1979, Xenobiotica; the fate of foreign compounds in biological systems.

[43]  J. Posternak,et al.  Toxicological tests on flavouring matters. II. Pyrazines and other compounds. , 1975, Food and cosmetics toxicology.