Solid pseudopapillary neoplasm of pancreas in a 12-year-old girl

A-12-year old girl presented with acute exacerbation of mild upper abdominal pain and nausea associated with weight loss. Subsequent work up revealed raised serum lipase and a bulky (7.8 cm x 4.9 cm x 2 cm) mass involving the head of the pancreas with areas of necrosis and cystic degeneration and peripheral rim enhancement, without any calcification. MPD was dilated (6mm). The cyst fluid had normal amylase, CA 19-9 level, CEA levels, and cytology revealed atypical epithelial cells. Patient underwent an uneventful pancreaticoduodenectomy. Subsequent histopathology revealed solid pseudopapillary tumor of the pancreas of low-grade malignancy.

[1]  S. Shrikhande,et al.  Analysis of 50 cases of solid pseudopapillary tumor of pancreas: Aggressive surgical resection provides excellent outcomes. , 2019, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[2]  C. F. Fernandez-del Castillo,et al.  Diagnosis and Management of Pancreatic Cystic Neoplasms. , 2015, Hematology/oncology clinics of North America.

[3]  R. Thakkar,et al.  Solid pseudopapillary neoplasm of the pancreas in pediatric patients: A case report and institutional case series , 2015 .

[4]  S. Yakan,et al.  Diagnosis and treatment of solid pseudopapillary tumor of the pancreas: experience of one single institution from Turkey , 2013, World Journal of Surgical Oncology.

[5]  A. El Nakeeb,et al.  Solid pseudopapillary tumour of the pancreas: Incidence, prognosis and outcome of surgery (single center experience). , 2013, International journal of surgery.

[6]  F. Rotellar,et al.  Solid pseudopapillary tumor of the pancreas (SPPT). Still an unsolved enigma. , 2010, Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva.

[7]  Zaher Chakhachiro,et al.  Solid-pseudopapillary neoplasm: a pancreatic enigma. , 2009, Archives of pathology & laboratory medicine.

[8]  J. Cameron,et al.  Surgical management of solid-pseudopapillary neoplasms of the pancreas (Franz or Hamoudi tumors): a large single-institutional series. , 2009, Journal of the American College of Surgeons.

[9]  H. Pitt,et al.  Cystic Pancreatic Neoplasms: Observe or Operate , 2004, Annals of surgery.

[10]  C. Vollmer,et al.  Management of a solid pseudopapillary tumor of the pancreas with liver metastases. , 2003, HPB : the official journal of the International Hepato Pancreato Biliary Association.

[11]  C. Forsmark,et al.  Cystic neoplasms of the pancreas , 2000 .

[12]  J. Grosfeld,et al.  Papillary epithelial neoplasm of pancreas in a child. Report of a case with electron microscopy , 1970, Cancer.

[13]  V. Frantz.  Papillary tumors of the Pancreas : Benign or malignant? , 1959 .