The Biologic Clock: The Mitochondria?

The author suggests that the maximal life span of a given mammalian species is largely an expression of genetic control over the rate of oxygen utilization. The latter determines the rate of accumulation of mitochondrial damage produced by free radical reactions, the rate increasing with the rate of oxygen consumption, which ultimately causes death.

[1]  K Schmidt-Nielsen,et al.  Energy metabolism, body size, and problems of scaling. , 1970, Federation proceedings.

[2]  B. Woodhall,et al.  Prospects for further increase in average longevity. , 1957, Geriatrics.

[3]  J. H. Wang Oxidative and photosynthetic phosphorylation mechanisms. , 1970, Science.

[4]  E. C. Weinbach,et al.  Oxidative phosphorylation in mitochondria from aged rats. , 1959, The Journal of biological chemistry.

[5]  D. Thornhill,et al.  Amino acid composition of human aortic elastin as influenced by age. , 1966, Journal of gerontology.

[6]  H. Tauchi,et al.  Age changes in size and number of mitochondria of human hepatic cells. , 1968, Journal of gerontology.

[7]  D. Harman PROLONGATION OF LIFE: ROLE OF FREE RADICAL REACTIONS IN AGING , 1969, Journal of the American Geriatrics Society.

[8]  D. Harman Prolongation of the normal life span by radiation protection chemicals. , 1957, Journal of gerontology.

[9]  F. E. Hunter,et al.  Phosphorylation coupled to oxidation of thiol groups (GSH) by cytochrome c with disulfide (GSSG) as an essential catalyst. IV. Stability of intermediates and possible mechanism of reaction. , 1970, Biochemical and biophysical research communications.

[10]  D. Harman Aging: a theory based on free radical and radiation chemistry. , 1956, Journal of gerontology.

[11]  D. Harman Atherosclerosis: a hypothesis concerning the initiating steps in pathogenesis. , 1957, Journal of gerontology.

[12]  D. Harman THE FREE RADICAL THEORY OF AGING: EFFECT OF AGE ON SERUM COPPER LEVELS. , 1965, Journal of gerontology.

[13]  F S LABELLA,et al.  STRUCTURE OF COLLAGEN FROM HUMAN TENDON AS INFLUENCED BY AGE AND SEX. , 1965, Journal of gerontology.

[14]  I. Isenberg FREE RADICALS IN TISSUE. , 1964, Physiological reviews.

[15]  D. Harman The free radical theory of aging: the effect of age on serum mercaptan levels. , 1960, Journal of gerontology.

[16]  D. Harman,et al.  Free radical theory of aging: effect of free radical reaction inhibitors on the mortality rate of male LAF mice. , 1968, Journal of gerontology.

[17]  D. Harman Prolongation of the normal lifespan and inhibition of spontaneous cancer by antioxidants. , 1961, Journal of gerontology.

[18]  早石 修,et al.  "Electronic aspects of biochemistry-生化学と電子論"シンポジウムに出席して , 1968 .

[19]  D. Harman,et al.  Role of free radicals in mutation, cancer, aging, and the maintenance of life. , 1962, Radiation research.

[20]  D. Harman,et al.  Free radical theory of aging: effect of the amount and degree of unsaturation of dietary fat on mortality rate. , 1971, Journal of gerontology.