Transient striatal &ggr; local field potentials signal movement initiation in rats

Transient coherent neural oscillations, as indicated by local field potentials, are thought to underlie key perceptual and cognitive events. We report a transient, state-dependent 50 Hz oscillation recorded from electrodes placed in the striatum of awake, behaving rats. These coherent oscillations, which we term &ggr;50, occurred in brief (150 ms) events co-incident with the initiation of movement. On navigation tasks, the animal's speed increased dramatically at the precise moment of the &ggr;50 event. This synchronous oscillation may provide a key to understanding striatal function, as well as basal ganglia pathology, which often impairs the control of voluntary movements.

[1]  A. Graybiel,et al.  Synchronous, Focally Modulated β-Band Oscillations Characterize Local Field Potential Activity in the Striatum of Awake Behaving Monkeys , 2003, The Journal of Neuroscience.

[2]  P. Brown,et al.  Event-related beta desynchronization in human subthalamic nucleus correlates with motor performance. , 2004, Brain : a journal of neurology.

[3]  H. Freund.  Mechanisms of voluntary movements. , 2002, Parkinsonism & related disorders.

[4]  Chris I. De Zeeuw,et al.  GATA-3 Is Involved in the Development of Serotonergic Neurons in the Caudal Raphe Nuclei , 1999, The Journal of Neuroscience.

[5]  Graybiel Am.  The basal ganglia and the initiation of movement. , 1990 .

[6]  Vincent Hayward,et al.  Discrete-time adaptive windowing for velocity estimation , 2000, IEEE Trans. Control. Syst. Technol..

[7]  A. Graybiel.  The basal ganglia and the initiation of movement. , 1990, Revue neurologique.

[8]  A. Redish,et al.  Neuronal activity in the rodent dorsal striatum in sequential navigation: separation of spatial and reward responses on the multiple T task. , 2004, Journal of neurophysiology.

[9]  P. Brown.  Oscillatory nature of human basal ganglia activity: Relationship to the pathophysiology of Parkinson's disease , 2003, Movement disorders : official journal of the Movement Disorder Society.

[10]  C. Marsden,et al.  The functions of the basal ganglia and the paradox of stereotaxic surgery in Parkinson's disease. , 1994, Brain : a journal of neurology.

[11]  Vanderwolf Ch.  Limbic-diencephalic mechanisms of voluntary movement. , 1971 .

[12]  C. G. Phillips.  THE BASAL GANGLIA AND THEIR RELATION TO DISORDERS OF MOVEMENT , 1962 .

[13]  A. Redish,et al.  Development of path stereotypy in a single day in rats on a multiple-T maze. , 2002, Archives italiennes de biologie.

[14]  G. Buzsáki,et al.  tFast Network Oscillations in the Hippocampal CA1 Region of the Behaving Rat , 1999, The Journal of Neuroscience.

[15]  W. Singer,et al.  Dynamic predictions: Oscillations and synchrony in top–down processing , 2001, Nature Reviews Neuroscience.

[16]  H. Eichenbaum,et al.  Oscillatory Entrainment of Striatal Neurons in Freely Moving Rats , 2004, Neuron.

[17]  A. Redish,et al.  Measuring fundamental frequencies in local field potentials , 2004, Journal of Neuroscience Methods.

[18]  C. H. Vanderwolf,et al.  Limbic-diencephalic mechanisms of voluntary movement. , 1971, Psychological review.

[19]  A. David Redish,et al.  Measuring neural coupling from non-Gaussian power spectra of voltage traces taken from awake behaving animals , 2003, SPIE International Symposium on Fluctuations and Noise.

[20]  G. Buzsáki,et al.  Neuronal Oscillations in Cortical Networks , 2004, Science.

[21]  Peter Brown,et al.  Oscillatory Local Field Potentials Recorded from the Subthalamic Nucleus of the Alert Rat , 2002, Experimental Neurology.

[22]  Wolf Singer,et al.  Striving for coherence , 1999 .

[23]  M Abeles,et al.  Activity of Pallidal and Striatal Tonically Active Neurons Is Correlated in MPTP-Treated Monkeys But Not in Normal Monkeys , 2001, The Journal of Neuroscience.

[24]  W Singer,et al.  Visual feature integration and the temporal correlation hypothesis. , 1995, Annual review of neuroscience.