Regional differences and temporal trends in male reproductive health disorders: Semen quality may be a sensitive marker of environmental exposures

[1]  Pinar Erkekoglu Belma Giray.  Phthalates and testicular dysgenesis syndrome , 2013 .

[2]  J. Toppari,et al.  Semen quality and reproductive hormone levels in men from Southern Spain , 2012, International journal of andrology.

[3]  J. Toppari,et al.  Recent adverse trends in semen quality and testis cancer incidence among Finnish men , 2011, International journal of andrology.

[4]  J. Mendiola,et al.  Associations between urinary metabolites of di(2-ethylhexyl) phthalate and reproductive hormones in fertile men. , 2011, International journal of andrology.

[5]  U. N. Joensen,et al.  Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. , 2011, Human reproduction.

[6]  J. Toppari,et al.  Prenatal and adult exposures to smoking are associated with adverse effects on reproductive hormones, semen quality, final height and body mass index. , 2011, Human reproduction.

[7]  A. Giwercman,et al.  No secular trend over the last decade in sperm counts among Swedish men from the general population. , 2011, Human reproduction.

[8]  Niels Jørgensen,et al.  Shorter Anogenital Distance Predicts Poorer Semen Quality in Young Men in Rochester, New York , 2011, Environmental health perspectives.

[9]  S. Brunak,et al.  Many Putative Endocrine Disruptors Inhibit Prostaglandin Synthesis , 2010, Environmental health perspectives.

[10]  J. Toppari,et al.  Adverse Trends of Male Reproductive Health in Two Nordic Countries Indicate Environmental Problems , 2011 .

[11]  Søren Brunak,et al.  Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat. , 2011, Human reproduction.

[12]  Henrik Toft Sørensen,et al.  Maternal Use of Acetaminophen, Ibuprofen, and Acetylsalicylic Acid During Pregnancy and Risk of Cryptorchidism , 2010, Epidemiology.

[13]  Deborah Hughes,et al.  Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer , 2010, Nature Genetics.

[14]  Mark P Purdue,et al.  International Trends in the Incidence of Testicular Cancer, 1973-2002 , 2010, Cancer Epidemiology, Biomarkers & Prevention.

[15]  G. P. Herbison,et al.  The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis. , 2010, Human reproduction update.

[16]  T. Toth,et al.  Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. , 2010, Fertility and sterility.

[17]  N. Skakkebaek,et al.  Testicular germ cell cancer incidence in an immigration perspective, Denmark, 1978 to 2003. , 2010, The Journal of urology.

[18]  M. Faust,et al.  Combined exposures to anti-androgenic chemicals: steps towards cumulative risk assessment. , 2010, International journal of andrology.

[19]  S. Brunak,et al.  Country-specific chemical signatures of persistent environmental compounds in breast milk. , 2010, International journal of andrology.

[20]  J. Furr,et al.  Cumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicity. , 2010, International journal of andrology.

[21]  N. Skakkebaek,et al.  Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesis. , 2010, International journal of andrology.

[22]  P. Korrovits,et al.  Increased Prevalance of the -211 T allele of follicle stimulating hormone (FSH) beta subunit promoter polymorphism and lower serum FSH in infertile men. , 2010, The Journal of clinical endocrinology and metabolism.

[23]  K. Strandberg-Larsen,et al.  Alcohol binge drinking during pregnancy and cryptorchidism. , 2009, Human reproduction.

[24]  J. Angerer,et al.  Urinary di(2-ethylhexyl)phthalate (DEHP)--metabolites and male human markers of reproductive function. , 2009, International journal of hygiene and environmental health.

[25]  A. Kortenkamp,et al.  Synergistic Disruption of External Male Sex Organ Development by a Mixture of Four Antiandrogens , 2009, Environmental health perspectives.

[26]  Nandita Mitra,et al.  Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer , 2009, Nature Genetics.

[27]  N. Jørgensen,et al.  Associations between andrological measures, hormones and semen quality in fertile Australian men: inverse relationship between obesity and sperm output. , 2009, Human reproduction.

[28]  D. Dunger,et al.  The descriptive epidemiology of congenital and acquired cryptorchidism in a UK infant cohort , 2009, Archives of Disease in Childhood.

[29]  A. S. Juncker,et al.  Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte. , 2009, Cancer research.

[30]  Deborah Hughes,et al.  A genome-wide association study of testicular germ cell tumor , 2009, Nature Genetics.

[31]  A. Calafat,et al.  Urinary metabolites of di(2-ethylhexyl) phthalate are associated with decreased steroid hormone levels in adult men. , 2009, Journal of andrology.

[32]  A. A. Jensen,et al.  Do Perfluoroalkyl Compounds Impair Human Semen Quality? , 2009, Environmental health perspectives.

[33]  J. Furr,et al.  Cumulative Effects of In Utero Administration of Mixtures of “Antiandrogens” on Male Rat Reproductive Development , 2007, Toxicologic pathology.

[34]  Jan Hauke,et al.  Prediction of spontaneous conception based on semen parameters. , 2008, International journal of andrology.

[35]  Jens Peter Bonde,et al.  Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile? , 2008, Fertility and sterility.

[36]  J. Toppari,et al.  Risk Factors for Congenital Cryptorchidism in a Prospective Birth Cohort Study , 2008, PloS one.

[37]  M. Punab,et al.  FSHB promoter polymorphism within evolutionary conserved element is associated with serum FSH level in men , 2008, Human reproduction.

[38]  M Scholze,et al.  Combined exposure to anti-androgens causes markedly increased frequencies of hypospadias in the rat. , 2008, International journal of andrology.

[39]  Andreas Kortenkamp,et al.  Low dose mixture effects of endocrine disrupters: implications for risk assessment and epidemiology. , 2008, International journal of andrology.

[40]  Niels Jørgensen,et al.  Semen quality in sub-fertile range for a significant proportion of young men from the general German population: a co-ordinated, controlled study of 791 men from Hamburg and Leipzig. , 2008, International journal of andrology.

[41]  Lee B. Smith,et al.  Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism. , 2008, The Journal of clinical investigation.

[42]  J. Toppari,et al.  Adverse trends in male reproductive health: we may have reached a crucial ‘tipping point’ , 2008, International journal of andrology.

[43]  Eva Bay Wedebye,et al.  Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism. , 2008, Chemical research in toxicology.

[44]  E. Budtz-Jørgensen,et al.  Impaired Reproductive Development in Sons of Women Occupationally Exposed to Pesticides during Pregnancy , 2008, Environmental health perspectives.

[45]  S. Krawetz,et al.  A Pilot Study Associating Urinary Concentrations of Phthalate Metabolites and Semen Quality , 2008, Systems biology in reproductive medicine.

[46]  A. Berenguer Sánchez,et al.  [Trends in the incidence of testicular germ cell cancer in a 300.000 inhabitants Spanish population (1991-2005)]. , 2008, Actas urologicas espanolas.

[47]  M. L. Galán,et al.  Tendencia en la incidencia del cáncer testicular de células germinales en un área sanitaria española de 300.000 habitantes (1991-2005) , 2008 .

[48]  J. Bonde,et al.  Prenatal alcohol exposure and cryptorchidism , 2007, Acta paediatrica.

[49]  J. Toppari,et al.  Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations. , 2007, International journal of andrology.

[50]  J. Olsen,et al.  Is prenatal exposure to tobacco smoking a cause of poor semen quality? A follow-up study. , 2007, American journal of epidemiology.

[51]  Mariana F. Fernández,et al.  Human Exposure to Endocrine-Disrupting Chemicals and Prenatal Risk Factors for Cryptorchidism and Hypospadias: A Nested Case–Control Study , 2007, Environmental health perspectives.

[52]  T. Backhaus,et al.  Low-Level Exposure to Multiple Chemicals: Reason for Human Health Concerns? , 2007, Environmental health perspectives.

[53]  N. Nassar,et al.  Increasing prevalence of hypospadias in Western Australia, 1980–2000 , 2007, Archives of Disease in Childhood.

[54]  J. Richie.  Trends in testicular cancer incidence and mortality in 22 European countries: continuing increases in incidence and declines in mortality , 2007 .

[55]  J. Olsen,et al.  Cryptorchidism According to Maternal Gestational Smoking , 2007, Epidemiology.

[56]  Claire V. Harper,et al.  [Ca2+]i signalling in sperm — making the most of what you've got , 2007, Nature Cell Biology.

[57]  A. Calafat,et al.  DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites. , 2007, Human reproduction.

[58]  J. Toppari,et al.  Cryptorchidism and Maternal Alcohol Consumption during Pregnancy , 2006, Environmental health perspectives.

[59]  A. Calafat,et al.  Altered Semen Quality in Relation to Urinary Concentrations of Phthalate Monoester and Oxidative Metabolites , 2006, Epidemiology.

[60]  J. Thorup,et al.  The incidence of bilateral cryptorchidism is increased and the fertility potential is reduced in sons born to mothers who have smoked during pregnancy. , 2006, The Journal of urology.

[61]  E. R. Meyts.  Developmental model for the pathogenesis of testicular carcinoma in situ: genetic and environmental aspects , 2006 .

[62]  R. Sharpe.  Pathways of endocrine disruption during male sexual differentiation and masculinization. , 2006, Best practice & research. Clinical endocrinology & metabolism.

[63]  N. Skakkebaek,et al.  Semen quality of 324 fertile Japanese men. , 2006, Human reproduction.

[64]  K. Schramm,et al.  Persistent Pesticides in Human Breast Milk and Cryptorchidism , 2006, Environmental health perspectives.

[65]  Henrik Møller,et al.  Trends in testicular cancer incidence in the Nordic countries, focusing on the recent decrease in Denmark. , 2006, International journal of andrology.

[66]  Jorma Toppari,et al.  Human Breast Milk Contamination with Phthalates and Alterations of Endogenous Reproductive Hormones in Infants Three Months of Age , 2005, Environmental health perspectives.

[67]  P. Chinnaswamy,et al.  Effect of chronic alcoholism on male fertility hormones and semen quality. , 2005, Fertility and sterility.

[68]  B. Graubard,et al.  Increasing incidence of testicular germ cell tumors among black men in the United States. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[69]  J. Toppari,et al.  Hypospadias in a cohort of 1072 Danish newborn boys: prevalence and relationship to placental weight, anthropometrical measurements at birth, and reproductive hormone levels at three months of age. , 2005, The Journal of clinical endocrinology and metabolism.

[70]  L. Hagmar,et al.  Urinary Phthalate Metabolites and Biomarkers of Reproductive Function in Young Men , 2005, Epidemiology.

[71]  R. Kruse,et al.  Decrease in Anogenital Distance among Male Infants with Prenatal Phthalate Exposure , 2005, Environmental health perspectives.

[72]  T. K. Jensen,et al.  Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. , 2004, Fertility and sterility.

[73]  A. Martini,et al.  Effects of alcohol and cigarette consumption on human seminal quality. , 2004, Fertility and sterility.

[74]  J. Toppari,et al.  Difference in prevalence of congenital cryptorchidism in infants between two Nordic countries , 2004, The Lancet.

[75]  J. Fisher,et al.  Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome. , 2004, Reproduction.

[76]  K. Pienta,et al.  Testicular Cancer , 2009, Nature Reviews Disease Primers.

[77]  Niels Keiding,et al.  Association of in utero exposure to maternal smoking with reduced semen quality and testis size in adulthood: a cross-sectional study of 1,770 young men from the general population in five European countries. , 2004, American journal of epidemiology.

[78]  N. Skakkebaek,et al.  Histological evidence of testicular dysgenesis in contralateral biopsies from 218 patients with testicular germ cell cancer , 2003, The Journal of pathology.

[79]  R. Sharpe,et al.  Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate. , 2003, Human reproduction.

[80]  R. Sharpe,et al.  Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood. , 2003, Reproduction.

[81]  Robert F. Herrick,et al.  Phthalate Exposure and Human Semen Parameters , 2003, Epidemiology.

[82]  Lone Storgaard,et al.  Does Smoking During Pregnancy Affect Sons’ Sperm Counts? , 2003, Epidemiology.

[83]  R. Sharpe.  The 'oestrogen hypothesis'- where do we stand now? , 2003, International journal of andrology.

[84]  N. Skakkebæk,et al.  Association between testicular dysgenesis syndrome (TDS) and testicular neoplasia: Evidence from 20 adult patients with signs of maldevelopment of the testis , 2003, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[85]  L. Quintana-Murci,et al.  Y chromosome haplogroups: A correlation with testicular dysgenesis syndrome? , 2003, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[86]  Fan Liu,et al.  Geographic differences in semen quality of fertile U.S. males. , 2002, Environmental health perspectives.

[87]  K. Hemminki,et al.  Reply to: "On cancer risks in second‐generation immigrants to Sweden" , 2002, International journal of cancer.

[88]  L. Hagmar,et al.  Higher sperm counts in Southern Sweden compared with Denmark. , 2002, Human reproduction.

[89]  N. Skakkebaek,et al.  Regional differences in semen qualities in the Baltic region. , 2002, International journal of andrology.

[90]  Niels Jørgensen,et al.  East-West gradient in semen quality in the Nordic-Baltic area: a study of men from the general population in Denmark, Norway, Estonia and Finland. , 2002, Human reproduction.

[91]  K. Czene,et al.  Cancer risks in first‐generation immigrants to Sweden , 2002, International journal of cancer.

[92]  Atar Baer,et al.  Maternal, Delivery, and Perinatal Characteristics Associated with Cryptorchidism: A Population-Based Case-Control Study among Births in Washington State , 2002, Epidemiology.

[93]  N. Keiding,et al.  Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities. , 2002, Human reproduction.

[94]  J. Auger,et al.  Semen quality and male reproductive health: the controversy about human sperm concentration decline , 2001, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[95]  N. Skakkebaek,et al.  Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects , 2001, Human reproduction.

[96]  J. Toppari,et al.  Trends in the incidence of cryptorchidism and hypospadias, and methodological limitations of registry-based data , 2001 .

[97]  Niels Keiding,et al.  Regional differences in semen quality in Europe , 2001, Human reproduction.

[98]  R. Pelham,et al.  Role of actin polymerization and actin cables in actin-patch movement in Schizosaccharomyces pombe , 2001, Nature Cell Biology.

[99]  J. Toppari,et al.  The birth rate of hypospadias in the Turku area in Finland Note , 2001, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[100]  Actor,et al.  SPERM MORPHOLOGY , MOTILITY , AND CONCENTRATION IN FERTILE AND INFERTILE MEN , 2001 .

[101]  R J Mitchell,et al.  Y-chromosomal diversity in Europe is clinal and influenced primarily by geography, rather than by language. , 2000, American journal of human genetics.

[102]  S. Swan,et al.  The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996. , 2000, Environmental health perspectives.

[103]  R. Mieusset,et al.  Increase in scrotal temperature in car drivers. , 2000, Human reproduction.

[104]  K. Dieckmann,et al.  Carcinoma in situ of the testis , 1991 .

[105]  Y. Kuroki,et al.  Spermatogenic ability is different among males in different Y chromosome lineage , 1999, Journal of Human Genetics.

[106]  S. Chia,et al.  What constitutes a normal seminal analysis? Semen parameters of 243 fertile men. , 1998, Human reproduction.

[107]  T. K. Jensen,et al.  Cryptorchidism and hypospadias in sons of gardeners and farmers. , 1998, Environmental health perspectives.

[108]  T. K. Jensen,et al.  Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners , 1998, The Lancet.

[109]  M J Goldacre,et al.  Prenatal risk factors for cryptorchidism: a record linkage study. , 1998, Paediatric and perinatal epidemiology.

[110]  L. Paulozzi,et al.  Hypospadias trends in two US surveillance systems. , 1998, Pediatrics.

[111]  David Handelsman.  Sperm output of healthy men in Australia: magnitude of bias due to self-selected volunteers. , 1997, Human reproduction.

[112]  S. Swan,et al.  Have sperm densities declined? A reanalysis of global trend data. , 1997, Environmental health perspectives.

[113]  L. Paulozzi,et al.  Hypospadias Trends in Two US Surveillance Systems , 1997 .

[114]  A. Andersen,et al.  Birth Defects among Offspring of Norwegian Farmers, 1967‐1991 , 1997, Epidemiology.

[115]  J. Nicolás,et al.  Testicular function in asymptomatic chronic alcoholics: relation to ethanol intake. , 1997, Alcoholism, clinical and experimental research.

[116]  A. Lenzi,et al.  Effects of prolonged autovehicle driving on male reproduction function: a study among taxi drivers. , 1996, American journal of industrial medicine.

[117]  Sharpe,et al.  Male reproductive health and environmental xenoestrogens. , 1996, Environmental health perspectives.

[118]  H. Adami,et al.  Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon. , 1996, Journal of the National Cancer Institute.

[119]  N. Berman,et al.  Data from men in greater Seattle area reveals no downward trend in semen quality: further evidence that deterioration of semen quality is not geographically uniform * † , 1996 .

[120]  J. H. Olson,et al.  Semen analyses in 1,283 men from the United States over a 25-year period: no decline in quality. , 1996, Fertility and sterility.

[121]  S. Irvine,et al.  Evidence of deteriorating semen quality in the United Kingdom: birth cohort study in 577 men in Scotland over 11 years , 1996, BMJ.

[122]  F. Comhaire,et al.  Deterioration of sperm quality in young healthy Belgian men. , 1996, Human reproduction.

[123]  S. Saarikoski,et al.  High and unchanged sperm counts of Finnish men. , 1996, International journal of andrology.

[124]  J. Auger,et al.  Debate about sperm count decline. , 1998, Environmental health perspectives.

[125]  T. Ord,et al.  Oocyte donation in humans: a model to study the effect of age on embryo implantation rate. , 1994, Human reproduction.

[126]  H. Adami,et al.  Testicular cancer in nine northern european countries , 1994, International journal of cancer.

[127]  A. Leviton,et al.  Correlates of decaffeinated coffee choice. , 1994, Epidemiology.

[128]  Guess Ha.  How should acute hepatic drug effects be studied epidemiologically , 1993 .

[129]  R. M. Sharpe,et al.  Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? , 1993, The Lancet.

[130]  N. Skakkebæk,et al.  Immunohistochemical markers of carcinoma in situ of the testis also expressed in normal infantile germ cells , 1993, Histopathology.

[131]  N Keiding,et al.  Evidence for decreasing quality of semen during past 50 years. , 1992, BMJ.

[132]  Cryptorchidism: a prospective study of 7500 consecutive male births, 1984-8. John Radcliffe Hospital Cryptorchidism Study Group. , 1992, Archives of disease in childhood.

[133]  R. Dougherty,et al.  Phthalate esters and semen quality parameters. , 1987, Biomedical & environmental mass spectrometry.

[134]  P. Sundström,et al.  Pregnancy rate in relation to number of cleaved eggs replaced after in-vitro fertilization in stimulated cycles monitored by serum levels of oestradiol and progesterone as sole index. , 1987, Human reproduction.

[135]  R. Menkveld,et al.  Possible changes in male fertility over a 15-year period. , 1986, Archives of andrology.

[136]  J. Ranstam,et al.  Depressed semen quality: a study over two decades. , 1984, Archives of andrology.

[137]  W. James.  Secular Trend in Reported Sperm Counts , 2009, Andrologia.

[138]  R. Falvo,et al.  Testosterone Regulation of Luteinizing Hormone Secretion in the Male Dog , 1979 .

[139]  O. Clausen,et al.  Effects of Hypophysectomy on LH Receptor Binding and Leydig Cell Sensitivity and Responsiveness to hCG/LH in the Immature (30 Day) Rat , 1979 .

[140]  L. Plöen,et al.  Studies on Regional Fine Structure and Function in the Rabbit Epididymis , 1979 .

[141]  M. Courot.  Prepubertal Development and Puberty: Comparative Aspects , 1978 .

[142]  C G SCORER,et al.  The Descent of the Testis , 1964, Archives of disease in childhood.

[143]  H. Henriksen,et al.  Incidence of undescended testis in the newborn. , 1961, Acta chirurgica Scandinavica. Supplementum.