A Wireless and Batteryless Microsystem with Implantable Grid Electrode/3-Dimensional Probe Array for ECoG and Extracellular Neural Recording in Rats

This paper presents the design, implementation, characterization and recording results of a wireless, batteryless microsystem for neural recording on rat, with implantable grid electrode and 3-dimensional probe array. The former provides brain surface ECoG acquisition, while the latter achieves 3D extracellular recording in the 3D target volume of tissue. The microsystem addressed the aforementioned properties by combining MEMS neural sensors, low-power circuit designs and commercial chips into system-level integration.

[1]  Wentai Liu,et al.  An optimal design methodology for inductive power link with class-E amplifier , 2005, IEEE Transactions on Circuits and Systems I: Regular Papers.

[2]  Reid R. Harrison,et al.  Designing Efficient Inductive Power Links for Implantable Devices , 2007, 2007 IEEE International Symposium on Circuits and Systems.

[3]  Jin-Chern Chiou,et al.  A wireless and batteryless microsystem with implantable grid electrode/3-dimensional probe array for ECoG and extracellular neural recording on rat , 2011 .

[4]  Jin-Chern Chiou,et al.  Development of a Three Dimensional Neural Sensing Device by a Stacking Method , 2010, Sensors.

[5]  Naoshige Uchida,et al.  A wireless multi-channel neural amplifier for freely moving animals , 2011, Nature Neuroscience.

[6]  Min-Yuan Cheng,et al.  Implantable Polyimide Cable for Multichannel High-Data-Rate Neural Recording Microsystems , 2012, IEEE Transactions on Biomedical Engineering.

[7]  Andreas Hierlemann,et al.  Impedance characterization and modeling of electrodes for biomedical applications , 2005, IEEE Transactions on Biomedical Engineering.

[8]  Antoine Depaulis,et al.  Endogenous control of epilepsy: The nigral inhibitory system , 1994, Progress in Neurobiology.

[9]  K. Wise,et al.  A Three-Dimensional 64-Site Folded Electrode Array Using Planar Fabrication , 2011, Journal of Microelectromechanical Systems.

[10]  P. Vaillancourt,et al.  EM radiation behavior upon biological tissues in a radio-frequency power transfer link for a cortical visual implant , 1997, Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136).

[11]  Eric M. Yeatman,et al.  Ultrasonic vs. Inductive Power Delivery for Miniature Biomedical Implants , 2010, 2010 International Conference on Body Sensor Networks.

[12]  Maysam Ghovanloo,et al.  Modeling and Optimization of Printed Spiral Coils in Air, Saline, and Muscle Tissue Environments , 2009, IEEE Transactions on Biomedical Circuits and Systems.

[13]  Xiaoqin Wang,et al.  Wireless multi-channel single unit recording in freely moving and vocalizing primates , 2012, Journal of Neuroscience Methods.

[14]  Sheng-Fu Liang,et al.  A Portable Wireless Online Closed-Loop Seizure Controller in Freely Moving Rats , 2011, IEEE Transactions on Instrumentation and Measurement.

[15]  Amir M. Sodagar,et al.  Microelectrodes, Microelectronics, and Implantable Neural Microsystems , 2008, Proceedings of the IEEE.

[16]  Maysam Ghovanloo,et al.  Design and Optimization of Printed Spiral Coils for Efficient Transcutaneous Inductive Power Transmission , 2007, IEEE Transactions on Biomedical Circuits and Systems.

[17]  W. Ko,et al.  Design of radio-frequency powered coils for implant instruments , 1977, Medical and Biological Engineering and Computing.

[18]  Maysam Ghovanloo,et al.  A low-noise clockless simultaneous 32-channel wireless neural recording system with adjustable resolution , 2011 .

[19]  M. Soljačić,et al.  Wireless Power Transfer via Strongly Coupled Magnetic Resonances , 2007, Science.

[20]  Christina Hassler,et al.  Miniaturized neural interfaces and implants , 2012, Photonics West - Micro and Nano Fabricated Electromechanical and Optical Components.

[21]  Qing Bai,et al.  Single-unit neural recording with active microelectrode arrays , 2001, IEEE Transactions on Biomedical Engineering.

[22]  Robert E. Hampson,et al.  A wireless recording system that utilizes Bluetooth technology to transmit neural activity in freely moving animals , 2009, Journal of Neuroscience Methods.

[23]  P. K. Chan,et al.  A CMOS analog front-end IC for portable EEG/ECG monitoring applications , 2005, IEEE Transactions on Circuits and Systems I: Regular Papers.

[24]  Ying Yao,et al.  A Microassembled Low-Profile Three-Dimensional Microelectrode Array for Neural Prosthesis Applications , 2007, Journal of Microelectromechanical Systems.

[25]  Chih-Wei Chang,et al.  Wireless powering electronics and spiral coils for implant microsystem toward nanomedicine diagnosis and therapy in free-behavior animal , 2012 .

[26]  T. Seese,et al.  Characterization of tissue morphology, angiogenesis, and temperature in the adaptive response of muscle tissue to chronic heating. , 1998, Laboratory investigation; a journal of technical methods and pathology.

[27]  D.J. Young,et al.  A Wireless and Batteryless 10-Bit Implantable Blood Pressure Sensing Microsystem With Adaptive RF Powering for Real-Time Laboratory Mice Monitoring , 2009, IEEE Journal of Solid-State Circuits.

[28]  Jin-Chern Chiou,et al.  Wireless powering electronics and spiral coils for implant microsystem toward nanomedicine diagnosis and therapy in free-behavior animal , 2011, The 4th IEEE International NanoElectronics Conference.

[29]  Andrew B. Schwartz,et al.  Brain-Controlled Interfaces: Movement Restoration with Neural Prosthetics , 2006, Neuron.

[30]  Reid R. Harrison,et al.  A Battery-Free Multichannel Digital Neural/EMG Telemetry System for Flying Insects , 2012, IEEE Transactions on Biomedical Circuits and Systems.

[31]  R. Oostenveld,et al.  A MEMS-based flexible multichannel ECoG-electrode array , 2009, Journal of neural engineering.

[32]  Klaus Finkenzeller,et al.  Book Reviews: RFID Handbook: Fundamentals and Applications in Contactless Smart Cards and Identification, 2nd ed. , 2004, ACM Queue.

[33]  Gabriel A. Rincon-Mora,et al.  A low-voltage, low quiescent current, low drop-out regulator , 1998, IEEE J. Solid State Circuits.