Protective Effects of Gynostemma Pentaphyllum in γ-irradiated Mice

Radiation protective effects of Gynostemma Pentaphyllum (Gp) were investigated in γ-irradiated mice. Animals were sacrificed on days 5, 15, 25 and 35 after γ-irradiation. GOT, GPT, serum IgG and leukocyte counts were measured. Proliferation of splenocytes stimulated by mitogens, such as PHA, Con A, and LPS were detected and compared. The results showed that all parameters measured in this study were decreased and proliferation of splenocytes stimulated by mitogens were repressed in γ-irradiated mice. Gp helped to recover the decreased leukocyte counts, GOT, GPT and IgG in serum and the proliferation of splenocytes stimulated by PHA, LPS and Con A in the γ-ray irradiated mice.