Lung cancer chemoprevention: current status and future prospects

[1]  J. DeGregori,et al.  Using functional genomics to overcome therapeutic resistance in hematological malignancies , 2013, Immunologic research.

[2]  Prabhat Jha,et al.  21st-century hazards of smoking and benefits of cessation in the United States. , 2013, The New England journal of medicine.

[3]  S. Suissa,et al.  The Use of Metformin and the Incidence of Lung Cancer in Patients With Type 2 Diabetes , 2012, Diabetes Care.

[4]  S. Jick,et al.  Metformin does not alter the risk of lung cancer: a case-control analysis. , 2012, Lung cancer.

[5]  J. Siegfried,et al.  Prevention of tobacco carcinogen-induced lung cancer in female mice using antiestrogens. , 2012, Carcinogenesis.

[6]  M. Sporn,et al.  Synthetic Oleanane Triterpenoids: Multifunctional Drugs with a Broad Range of Applications for Prevention and Treatment of Chronic Disease , 2012, Pharmacological Reviews.

[7]  H. Haick,et al.  Non-invasive Breath Analysis of Pulmonary Nodules , 2012, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[8]  Meng Xu,et al.  The effect of metformin and thiazolidinedione use on lung cancer in diabetics , 2012, BMC Cancer.

[9]  Steven J. M. Jones,et al.  Comprehensive genomic characterization of squamous cell lung cancers , 2012, Nature.

[10]  Angela N. Brooks,et al.  Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing , 2012, Cell.

[11]  Y. Miller,et al.  Alveolar Hypoxia Promotes Murine Lung Tumor Growth through a VEGFR-2/EGFR-Dependent Mechanism , 2012, Cancer Prevention Research.

[12]  C. la Vecchia,et al.  Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis. , 2012, The oncologist.

[13]  P. Rothwell,et al.  Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials. , 2012, The Lancet. Oncology.

[14]  Tetsuro Tsujimoto,et al.  Cancer Risk in Diabetic Patients Treated with Metformin: A Systematic Review and Meta-analysis , 2012, PloS one.

[15]  Ching-Chu Chen,et al.  Antidiabetes drugs correlate with decreased risk of lung cancer: a population-based observation in Taiwan. , 2012, Clinical lung cancer.

[16]  Gretchen L. Gierach,et al.  Unopposed estrogen and estrogen plus progestin menopausal hormone therapy and lung cancer risk in the NIH–AARP Diet and Health Study Cohort , 2012, Cancer Causes & Control.

[17]  Yan Lu,et al.  Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice , 2011, Molecular carcinogenesis.

[18]  E. Szabo,et al.  Criteria of evidence to move potential chemopreventive agents into late phase clinical trials. , 2011, Current drug targets.

[19]  S. Malkoski,et al.  N-nitroso-tris-chloroethylurea Induces Premalignant Squamous Dysplasia in Mice , 2011, Cancer Prevention Research.

[20]  J. Y. Park,et al.  Aspirin use and risk for lung cancer: a meta-analysis. , 2011, Annals of oncology : official journal of the European Society for Medical Oncology.

[21]  P. Snijders,et al.  DNA copy number alterations in endobronchial squamous metaplastic lesions predict lung cancer. , 2011, American journal of respiratory and critical care medicine.

[22]  D. Aberle,et al.  Reduced lung-cancer mortality with low-dose computed tomographic screening. , 2011, The New England journal of medicine.

[23]  John D. Minna,et al.  Divergent Genomic and Epigenomic Landscapes of Lung Cancer Subtypes Underscore the Selection of Different Oncogenic Pathways during Tumor Development , 2011, PloS one.

[24]  R. Elashoff,et al.  Lung Cancer Chemoprevention with Celecoxib in Former Smokers , 2011, Cancer Prevention Research.

[25]  Karen A Gelmon,et al.  Exemestane for breast-cancer prevention in postmenopausal women. , 2011, The New England journal of medicine.

[26]  Y. Miller,et al.  Oral Iloprost Improves Endobronchial Dysplasia in Former Smokers , 2011, Cancer Prevention Research.

[27]  R. Caprioli,et al.  Lung cancer diagnosis from proteomic analysis of preinvasive lesions. , 2011, Cancer research.

[28]  A. Ferrara,et al.  Cohort Study of Pioglitazone and Cancer Incidence in Patients With Diabetes , 2011, Diabetes Care.

[29]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[30]  Xianglin L. Du,et al.  Menopausal Hormone Therapy Does Not Influence Lung Cancer Risk: Results from the California Teachers Study , 2011, Cancer Epidemiology, Biomarkers & Prevention.

[31]  P. Rothwell,et al.  Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials , 2011, The Lancet.

[32]  S. Ferretti,et al.  Randomized Phase II Trial of Inhaled Budesonide versus Placebo in High-Risk Individuals with CT Screen–Detected Lung Nodules , 2010, Cancer Prevention Research.

[33]  Loyda B. Mendez,et al.  Inhaled aerosol particle dosimetry in mice: A review , 2010, Inhalation toxicology.

[34]  T. Key Fruit and vegetables and cancer risk , 2010, British Journal of Cancer.

[35]  Yan Lu,et al.  Chemopreventive Effects of Pioglitazone on Chemically Induced Lung Carcinogenesis in Mice , 2010, Molecular Cancer Therapeutics.

[36]  J. Manson,et al.  Lung cancer among postmenopausal women treated with estrogen alone in the women's health initiative randomized trial. , 2010, Journal of the National Cancer Institute.

[37]  J. Engelman,et al.  Chemoprevention Meets Glucose Control , 2010, Cancer Prevention Research.

[38]  R. Memmott,et al.  Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis , 2010, Cancer Prevention Research.

[39]  Y. Miller,et al.  Vascular Endothelial Growth Factor Receptor 2–Targeted Chemoprevention of Murine Lung Tumors , 2010, Cancer Prevention Research.

[40]  P. Dear,et al.  Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer. , 2010, American journal of respiratory and critical care medicine.

[41]  R. Marks,et al.  A phase III, intergroup, randomized, double-blind, chemoprevention trial of selenium (Se) supplementation in resected stage I non-small cell lung cancer (NSCLC). , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[42]  Stephen A. Williams,et al.  Unlocking Biomarker Discovery: Large Scale Application of Aptamer Proteomic Technology for Early Detection of Lung Cancer , 2010, PloS one.

[43]  Adam M. Gustafson,et al.  Airway PI3K Pathway Activation Is an Early and Reversible Event in Lung Cancer Development , 2010, Science Translational Medicine.

[44]  R. DuBois,et al.  Eicosanoids and cancer , 2010, Nature Reviews Cancer.

[45]  Edward S. Kim,et al.  Biological Activity of Celecoxib in the Bronchial Epithelium of Current and Former Smokers , 2010, Cancer Prevention Research.

[46]  J. Siegfried,et al.  Estrogen receptor signaling in lung cancer. , 2009, Seminars in oncology.

[47]  Y. Miller,et al.  A Randomized Phase II Chemoprevention Trial of 13-CIS Retinoic Acid with Or without α Tocopherol or Observation in Subjects at High Risk for Lung Cancer , 2009, Cancer Prevention Research.

[48]  G Block,et al.  The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study in Finland. , 2009, Nutrition reviews.

[49]  P. Metcalf,et al.  COPD prevalence is increased in lung cancer, independent of age, sex and smoking history , 2009, European Respiratory Journal.

[50]  S. Narumiya,et al.  Prostacyclin Prevents Murine Lung Cancer Independent of the Membrane Receptor by Activation of Peroxisomal Proliferator–Activated Receptor γ , 2008, Cancer Prevention Research.

[51]  M. Spitz,et al.  An Expanded Risk Prediction Model for Lung Cancer , 2008, Cancer Prevention Research.

[52]  M. Sporn,et al.  The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis , 2008, Molecular Cancer Therapeutics.

[53]  L. Thiberville,et al.  Molecular predictive factors for progression of high-grade preinvasive bronchial lesions. , 2008, American journal of respiratory and critical care medicine.

[54]  E. Smit,et al.  CT detected indeterminate pulmonary nodules in a chemoprevention trial of fluticasone. , 2008, Lung cancer.

[55]  Hiromasa Yamamoto,et al.  Sequential Molecular Changes during Multistage Pathogenesis of Small Peripheral Adenocarcinomas of the Lung , 2008, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[56]  E. White,et al.  Long-term use of supplemental multivitamins, vitamin C, vitamin E, and folate does not reduce the risk of lung cancer. , 2008, American journal of respiratory and critical care medicine.

[57]  S. Lam,et al.  Chromosomal aneusomy in bronchial high-grade lesions is associated with invasive lung cancer. , 2008, American journal of respiratory and critical care medicine.

[58]  T. Byers,et al.  Bronchial Epithelial Ki-67 Index Is Related to Histology, Smoking, and Gender, but Not Lung Cancer or Chronic Obstructive Pulmonary Disease , 2007, Cancer Epidemiology Biomarkers & Prevention.

[59]  W. Pao,et al.  Development of New Mouse Lung Tumor Models Expressing EGFR T790M Mutants Associated with Clinical Resistance to Kinase Inhibitors , 2007, PloS one.

[60]  S. Belinsky,et al.  Rosiglitazone prevents the progression of preinvasive lung cancer in a murine model. , 2007, Carcinogenesis.

[61]  Matthew B Schabath,et al.  A risk model for prediction of lung cancer. , 2007, Journal of the National Cancer Institute.

[62]  E. Siegel,et al.  Thiazolidinediones and the risk of lung, prostate, and colon cancer in patients with diabetes. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[63]  D. Au,et al.  Inhaled corticosteroids and risk of lung cancer among patients with chronic obstructive pulmonary disease. , 2007, American journal of respiratory and critical care medicine.

[64]  M. Sporn,et al.  The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. , 2007, Cancer research.

[65]  P. Sebastiani,et al.  Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer , 2007, Nature Medicine.

[66]  A. Nicholson,et al.  Bronchioloalveolar Carcinoma and Lung Adenocarcinoma: The Clinical Importance and Research Relevance of the 2004 World Health Organization Pathologic Criteria , 2006, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[67]  Calum MacAulay,et al.  A Phase I Study of myo-Inositol for Lung Cancer Chemoprevention , 2006, Cancer Epidemiology Biomarkers & Prevention.

[68]  J. Minna,et al.  EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients. , 2005, Cancer research.

[69]  J. Manson,et al.  Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial. , 2005, JAMA.

[70]  Bibliography Current World Literature , 2005, Current opinion in gastroenterology.

[71]  S. Lam,et al.  A Randomized Phase IIb Trial of Pulmicort Turbuhaler (Budesonide) in People with Dysplasia of the Bronchial Epithelium , 2004, Clinical Cancer Research.

[72]  Gang Liu,et al.  Effects of cigarette smoke on the human airway epithelial cell transcriptome. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[73]  C. Morrison,et al.  A Chemically Induced Model for Squamous Cell Carcinoma of the Lung in Mice , 2004, Cancer Research.

[74]  V. Keshamouni,et al.  Peroxisome proliferator-activated receptor-γ activation inhibits tumor progression in non-small-cell lung cancer , 2004, Oncogene.

[75]  J. Verdebout,et al.  Epidermal growth factor receptor expression in pre-invasive and early invasive bronchial lesions , 2003, European Respiratory Journal.

[76]  C. Begg,et al.  Variations in lung cancer risk among smokers. , 2003, Journal of the National Cancer Institute.

[77]  L. Dwyer-Nield,et al.  Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice. , 2002, Carcinogenesis.

[78]  S. Lam,et al.  A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia. , 2002, Journal of the National Cancer Institute.

[79]  Y. Miller,et al.  Manipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer. , 2002, Cancer research.

[80]  H. Varmus,et al.  Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. , 2001, Genes & development.

[81]  T. Jacks,et al.  Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. , 2001, Genes & development.

[82]  A. Malkinson,et al.  Indomethacin reduces lung adenoma number in A/J mice. , 2001, Anticancer research.

[83]  T. Jacks,et al.  Somatic activation of the K-ras oncogene causes early onset lung cancer in mice , 2001, Nature.

[84]  S. Lippman,et al.  Randomized phase III intergroup trial of isotretinoin to prevent second primary tumors in stage I non-small-cell lung cancer. , 2001, Journal of the National Cancer Institute.

[85]  A. Nicholson,et al.  Reproducibility of the WHO/IASLC grading system for pre‐invasive squamous lesions of the bronchus: a study of inter‐observer and intra‐observer variation , 2001, Histopathology.

[86]  J. Connett,et al.  Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease. , 2000, The New England journal of medicine.

[87]  T. Willson,et al.  Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[88]  J. Mulshine,et al.  Topical delivery of 13-cis-retinoic acid by inhalation up-regulates expression of rodent lung but not liver retinoic acid receptors. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[89]  S. Lippman,et al.  N-(4-hydroxyphenyl)retinamide in the chemoprevention of squamous metaplasia and dysplasia of the bronchial epithelium. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[90]  O. Dalesio,et al.  EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the EUropean Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups. , 2000, Journal of the National Cancer Institute.

[91]  S. Spencer,et al.  Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial , 2000, BMJ : British Medical Journal.

[92]  Y. Miller,et al.  Angiogenic squamous dysplasia in bronchi of individuals at high risk for lung cancer. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[93]  Tsg-Hui Chang,et al.  Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor gamma in non-small cell lung cancer. , 2000, Cancer research.

[94]  V. Steele,et al.  Chemoprevention of pulmonary carcinogenesis by brief exposures to aerosolized budesonide or beclomethasone dipropionate and by the combination of aerosolized budesonide and dietary myo-inositol. , 2000, Carcinogenesis.

[95]  P. Lange,et al.  Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial , 1999, The Lancet.

[96]  J. Minna,et al.  Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma , 1999, Oncogene.

[97]  B. Johnson,et al.  Second lung cancers in patients after treatment for an initial lung cancer. , 1998, Journal of the National Cancer Institute.

[98]  H. Witschi Tobacco smoke as a mouse lung carcinogen. , 1998, Experimental lung research.

[99]  Y. Miller,et al.  Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis. , 1997, The Journal of clinical investigation.

[100]  A. Malkinson,et al.  Butylated hydroxytoluene exposure is necessary to induce lung tumors in BALB mice treated with 3-methylcholanthrene. , 1997, Cancer research.

[101]  M R Cullen,et al.  Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial. , 1996, Journal of the National Cancer Institute.

[102]  M. Spitz,et al.  Lung carcinoma in former smokers , 1996, Cancer.

[103]  G. Omenn,et al.  Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. , 1996, The New England journal of medicine.

[104]  J. Manson,et al.  Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. , 1996, The New England journal of medicine.

[105]  David B. Holiday,et al.  Beta-Carotene, vitamin A, and lung cancer chemoprevention: results of an intermediate endpoint study. , 1995, The American journal of clinical nutrition.

[106]  E. Dmitrovsky,et al.  Aberrant expression of p53 or the epidermal growth factor receptor is frequent in early bronchial neoplasia and coexpression precedes squamous cell carcinoma development. , 1995, Cancer research.

[107]  S. Lippman,et al.  Randomized placebo-controlled trial of isotretinoin in chemoprevention of bronchial squamous metaplasia. , 1994, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[108]  B. Gillespie,et al.  Patterns of absolute risk of lung cancer mortality in former smokers. , 1993, Journal of the National Cancer Institute.

[109]  L. Booker,et al.  The effect of the synthetic retinoid etretinate on sputum cytology: results from a randomised trial. , 1992, British Journal of Cancer.

[110]  R. Prentice Surrogate endpoints in clinical trials: definition and operational criteria. , 1989, Statistics in medicine.

[111]  D. Heimburger,et al.  Improvement in bronchial squamous metaplasia in smokers treated with folate and vitamin B12. Report of a preliminary randomized, double-blind intervention trial. , 1988, JAMA.

[112]  R. Doll,et al.  Randomised trial of prophylactic daily aspirin in British male doctors , 1988, British medical journal.

[113]  J. Vane Prostacyclin: a hormone with a therapeutic potential. The Sir Henry Dale Lecture for 1981. , 1982, The Journal of endocrinology.

[114]  M. Sporn Approaches to prevention of epithelial cancer during the preneoplastic period. , 1976, Cancer research.

[115]  D. Slaughter,et al.  “Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin , 1953, Cancer.

[116]  Kyung Soo Lee,et al.  Natural history of pure ground-glass opacity lung nodules detected by low-dose CT scan. , 2013, Chest.

[117]  A. Jemal,et al.  Cancer statistics, 2012 , 2012, CA: a cancer journal for clinicians.

[118]  C. Gatsonis,et al.  Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening , 2012 .

[119]  A. Jemal,et al.  Global cancer statistics , 2011, CA: a cancer journal for clinicians.

[120]  Raphael A Nemenoff,et al.  Tumorigenesis and Neoplastic Progression Analysis of Orthologous Gene Expression between Human Pulmonary Adenocarcinoma and a Carcinogen-Induced Murine Model , 2010 .

[121]  A. Potti,et al.  Hormone replacement therapy is associated with decreased survival in women with lung cancer. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[122]  P. Lønning,et al.  The ne w e ngl and j our na l of medicine , 2006 .

[123]  N. Dubrawsky Cancer statistics , 1989, CA: a cancer journal for clinicians.

[124]  Final report on the aspirin component of the ongoing Physicians' Health Study. , 1989, The New England journal of medicine.

[125]  S. Mirvish The carcinogenic action and metabolism of urethan and N-hydroxyurethan. , 1968, Advances in cancer research.

[126]  C. Coulson Electronic configuration and carcinogenesis. , 1953, Advances in cancer research.