Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease

[1]  I. Vujkovic-Cvijin,et al.  Broadly effective metabolic and immune recovery with C5 inhibition in CHAPLE disease , 2020, Nature Immunology.

[2]  L. Kane,et al.  Noncanonical STAT3 activity sustains pathogenic Th17 proliferation and cytokine response to antigen , 2020, The Journal of experimental medicine.

[3]  Inkyung Jung,et al.  Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 , 2020, Science Immunology.

[4]  Andrew J. Oler,et al.  HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease , 2020, Science.

[5]  armen Berasaina,et al.  Amphiregulin , 2020, Definitions.

[6]  Jing Wang,et al.  WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs , 2019, Nucleic Acids Res..

[7]  M. Freeman,et al.  The molecular, cellular and pathophysiological roles of iRhom pseudoproteases , 2019, Open Biology.

[8]  H. Ochs,et al.  Hyper IgE syndromes: clinical and molecular characteristics , 2018, Immunology and cell biology.

[9]  C. Huttenhower,et al.  Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course. , 2018, Cell host & microbe.

[10]  H. Hammad,et al.  The emerging role of ADAM metalloproteinases in immunity , 2018, Nature Reviews Immunology.

[11]  Linfeng Hu,et al.  iRhom2 loss alleviates renal injury in long-term PM2.5-exposed mice by suppression of inflammation and oxidative stress , 2018, Redox biology.

[12]  M. Wiles,et al.  ADAM17 is essential for ectodomain shedding of the EGF‐receptor ligand amphiregulin , 2018, FEBS open bio.

[13]  J. S. Kim,et al.  Role of iRhom2 in intestinal ischemia-reperfusion-mediated acute lung injury , 2018, Scientific Reports.

[14]  S. Rose-John,et al.  The shedding protease ADAM17: Physiology and pathophysiology. , 2017, Biochimica et biophysica acta. Molecular cell research.

[15]  H. Shu,et al.  iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA , 2017, PLoS pathogens.

[16]  J. Segre,et al.  Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation , 2017, Science.

[17]  A. von Kriegsheim,et al.  Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE , 2017, Cell reports.

[18]  Yuhong Yang,et al.  IL-23R-activated STAT3/STAT4 is essential for Th1/Th17-mediated CNS autoimmunity. , 2017, JCI insight.

[19]  M. Wiles,et al.  Genetic deletion of amphiregulin restores the normal skin phenotype in a mouse model of the human skin disease tylosis , 2017, Biology Open.

[20]  M. Freeman,et al.  Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling , 2017, eLife.

[21]  Brendan H. Lee,et al.  P3h3-null and Sc65-null Mice Phenocopy the Collagen Lysine Under-hydroxylation and Cross-linking Abnormality of Ehlers-Danlos Syndrome Type VIA* , 2017, The Journal of Biological Chemistry.

[22]  J. W. Collins,et al.  Citrobacter rodentium mouse model of bacterial infection , 2016, Nature Protocols.

[23]  H. Shu,et al.  iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING , 2016, Nature Immunology.

[24]  John C. Marioni,et al.  Hierarchical deconstruction of mouse olfactory sensory neurons: from whole mucosa to single-cell RNA-seq , 2015, Scientific Reports.

[25]  G. Weskamp,et al.  iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling , 2015, Proceedings of the National Academy of Sciences.

[26]  W. Gause,et al.  Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair. , 2015, Immunity.

[27]  H. Nie,et al.  TNFα Promotes Th17 Cell Differentiation through IL-6 and IL-1β Produced by Monocytes in Rheumatoid Arthritis , 2014, Journal of immunology research.

[28]  M. Freeman.  The rhomboid-like superfamily: molecular mechanisms and biological roles. , 2014, Annual review of cell and developmental biology.

[29]  B. Finlay,et al.  Citrobacter rodentium: infection, inflammation and the microbiota , 2014, Nature Reviews Microbiology.

[30]  D. Kelsell,et al.  iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function. , 2014, Human molecular genetics.

[31]  K. Johnson,et al.  Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin , 2014, Proceedings of the National Academy of Sciences.

[32]  S. Uhlig,et al.  Smooth Muscle Cells Relay Acute Pulmonary Inflammation via Distinct ADAM17/ErbB Axes , 2014, The Journal of Immunology.

[33]  M. Freeman,et al.  Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation , 2013, EMBO reports.

[34]  K. Horiuchi,et al.  iRHOM2 is a critical pathogenic mediator of inflammatory arthritis. , 2013, The Journal of clinical investigation.

[35]  S. Holland,et al.  An update on the hyper-IgE syndromes , 2012, Arthritis Research & Therapy.

[36]  R. Mason,et al.  Efficient and rapid isolation and purification of mouse alveolar type II epithelial cells , 2012, Experimental lung research.

[37]  C. Huttenhower,et al.  Metagenomic microbial community profiling using unique clade-specific marker genes , 2012, Nature Methods.

[38]  L. Aaltonen,et al.  Analysis of a Finnish family confirms RHBDF2 mutations as the underlying factor in tylosis with esophageal cancer , 2012, Familial Cancer.

[39]  D. Bishop,et al.  RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome. , 2012, American journal of human genetics.

[40]  M. Freeman,et al.  Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE , 2012, Science.

[41]  C. Blobel,et al.  iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS , 2012, Science.

[42]  Rob Knight,et al.  Bayesian community-wide culture-independent microbial source tracking , 2011, Nature Methods.

[43]  Jing Chen,et al.  ToppGene Suite for gene list enrichment analysis and candidate gene prioritization , 2009, Nucleic Acids Res..

[44]  K. Boyd,et al.  Cytokine secretion requires phosphatidylcholine synthesis , 2008, The Journal of cell biology.

[45]  C. Mamotte,et al.  Phenylketonuria: an inborn error of phenylalanine metabolism. , 2008, The Clinical biochemist. Reviews.

[46]  C. Liang,et al.  In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro , 2007, Nature Protocols.

[47]  B. Ryffel,et al.  Membrane TNF confers protection to acute mycobacterial infection , 2005, Respiratory research.

[48]  S. Batalov,et al.  A gene atlas of the mouse and human protein-encoding transcriptomes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[49]  A. Schäffer,et al.  Genetic linkage of hyper-IgE syndrome to chromosome 4. , 1999, American journal of human genetics.

[50]  G. Dougan,et al.  Citrobacter rodentium Infection in Mice Elicits a Mucosal Th1 Cytokine Response and Lesions Similar to Those in Murine Inflammatory Bowel Disease , 1999, Infection and Immunity.

[51]  M. Lambert,et al.  Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α , 1997, Nature.

[52]  Nicole Nelson,et al.  A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells , 1997, Nature.

[53]  R. Rappuoli,et al.  Development of a mouse model of Helicobacter pylori infection that mimics human disease , 1995, Science.

[54]  R. Zinkernagel,et al.  Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes , 1993, Nature.

[55]  G. Aversa,et al.  The 26-kD transmembrane form of tumor necrosis factor alpha on activated CD4+ T cell clones provides a costimulatory signal for human B cell activation , 1993, The Journal of experimental medicine.

[56]  T. Mak,et al.  Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection , 1993, Cell.

[57]  J. Fox,et al.  A small animal model of human Helicobacter pylori active chronic gastritis. , 1990, Gastroenterology.

[58]  C. Blobel,et al.  iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling , 2021 .

[59]  P. Vassalli,et al.  The pathophysiology of tumor necrosis factors. , 1992, Annual review of immunology.