IN SILICO PHARMACOPHORE VALIDATION OF ANTICONVULSANT ACTIVITY OF (E) (±)-3-MENTHONE DERIVATIVES

Department of Pharmaceutical Chemistry, RamEesh Institute of Vocational and Technical Education, Greater Noida-201 310, Uttar Pradesh, India School of Pharmacy, Bharat Institute of Technology, Meerut-250 103, Uttar Pradesh, India D.A.V. Post Graduate College, Dehradun-248 121, Uttaranchal-248 121, India Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ferozpur Road, Moga-142 001, Punjab, India

[1]  K. Bothara,et al.  Design, synthesis and pharmacological screening of potential anticonvulsant agents using hybrid approach. , 2010, European journal of medicinal chemistry.

[2]  P. Yogeeswari,et al.  Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design. , 2005, Journal of medicinal chemistry.

[3]  N. Aggarwal,et al.  Synthesis and Evaluation of Schiff Bases for Anticonvulsant and Behavioral Depressant Properties , 2007 .

[4]  STRUCTURE BASED RATIONAL DRUG DESIGN OF SELECTIVE PHOSPHODIESTERASE-4 LIGANDS AS ANTI-INFLAMMATORY MOLECULES , 2011 .

[5]  J. Stables,et al.  Menthone aryl acid hydrazones: a new class of anticonvulsants. , 2011, Medicinal chemistry.

[6]  J. Sidrim,et al.  Antinociceptive, anticonvulsant and antibacterial effects of the essential oil from the flower heads of Egletes viscosa L , 1998 .

[7]  A. V. Adhikari,et al.  A new class of anticonvulsants possessing 6 Hz activity: 3,4-dialkyloxy thiophene bishydrazones. , 2009, European journal of medicinal chemistry.

[8]  Paola Storici,et al.  Structures of γ-Aminobutyric Acid (GABA) Aminotransferase, a Pyridoxal 5′-Phosphate, and [2Fe-2S] Cluster-containing Enzyme, Complexed with γ-Ethynyl-GABA and with the Antiepilepsy Drug Vigabatrin* , 2003, Journal of Biological Chemistry.

[9]  J. Duncan.  The promise of new antiepileptic drugs. , 2002, British journal of clinical pharmacology.

[10]  M. Eadie,et al.  Anticonvulsant Therapy: Pharmacological Basis and Practice , 1974 .

[11]  A. V. Adhikari,et al.  Synthesis and anticonvulsant activity of some new bishydrazones derived from 3,4-dipropyloxythiophene. , 2009, European journal of medicinal chemistry.

[12]  Vipin Kumar.  TOPOLOGICAL MODELS FOR THE PREDICTION OF TYROSINE KINASE INHIBITORY ACTIVITY OF 4-ANILINOQUINAZOLINES , 2011 .

[13]  J. Stables,et al.  Synthesis of isatin semicarbazones as novel anticonvulsants--role of hydrogen bonding. , 2002, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[14]  D. Woodbury,et al.  Anticonvulsant structure‐activity relationships: Historical development and probable causes of failure , 1982 .

[15]  J. Kuldo,et al.  Stereochemistry of terpene derivatives. Part 2: Synthesis of new chiral amino acids with potential neuroactivity , 2000 .

[16]  Emma Greenwood,et al.  Tumour suppressors: A new class? , 2001, Nature Reviews Cancer.

[17]  H. Lankau,et al.  Synthesis, anticonvulsant activity, and structure-activity relationships of sodium channel blocking 3-aminopyrroles. , 1998, Journal of medicinal chemistry.

[18]  Vikas Sharma,et al.  PHARMACOPHORE MODELING STUDIES ON XANTHONES AS MONOAMINE OXIDASE-A INHIBITORS , 2011 .

[19]  J. Quail,et al.  Evaluation of the semicarbazones, thiosemicarbazones and bis-carbohydrazones of some aryl alicycylic ketones for anticonvulsant and other biological propertie , 1995 .

[20]  S. Pascarella,et al.  Active site model for γ‐aminobutyrate aminotransferase explains substrate specificity and inhibitor reactivities , 1995, Protein science : a publication of the Protein Society.

[21]  P. Singh,et al.  Anticonvulsant activity of thioureido derivatives of acetophenone semicarbazone. , 1998, Pharmacological research.