Prebiotic Feed Additives: Rationale and Use in Pigs

Disease has always been a critical issue in pig production, affecting not only animal health and well-being, but also the physical and economic health of the producer. Growth promotant antibiotics have been fed to livestock since the 1940’s and have generally enhanced pig performance (Cromwell, 2000). Growth promotant antibiotics act by a variety of mechanisms to alter the intestinal microbiota, with subsequent direct and indirect effects on the pig (Anderson, et al., 2000, Gaskins et al., 2000). Enteric disease issues are coming to the forefront as governmental and public concerns about preharvest food safety and microbial antibiotic resistance increase. The European Union is phasing out use of growth promotant antibiotics and there is increasing pressure to do so in North America.

[1]  L. T. Angenent,et al.  Getting a grip on things: how do communities of bacterial symbionts become established in our intestine? , 2004, Nature Immunology.

[2]  S. Salminen,et al.  Microbial-gut interactions in health and disease. Probiotics. , 2004, Best practice & research. Clinical gastroenterology.

[3]  T. Macdonald,et al.  Microbial-gut interactions in health and disease. Immune responses. , 2004, Best practice & research. Clinical gastroenterology.

[4]  M. Lyte.  Microbial endocrinology and infectious disease in the 21st century. , 2004, Trends in microbiology.

[5]  G. Fahey,et al.  Nutritional Responses to the Presence of Inulin and Oligofructose in the Diets of Domesticated Animals: A Review , 2003, Critical reviews in food science and nutrition.

[6]  Gary L. Cromwell,et al.  WHY AND HOW ANTIBIOTICS ARE USED IN SWINE PRODUCTION , 2002, Animal biotechnology.

[7]  R. Buddington,et al.  Non–digestible oligosaccharides and defense functions: lessons learned from animal models , 2002, British Journal of Nutrition.

[8]  J. Schrezenmeir,et al.  Inulin, oligofructose and mineral metabolism — experimental data and mechanism , 2002, British Journal of Nutrition.

[9]  H. Gaskins,et al.  ANTIBIOTICS AS GROWTH PROMOTANTS:MODE OF ACTION , 2002, Animal biotechnology.

[10]  J. Saavedra,et al.  Human studies with probiotics and prebiotics: clinical implications , 2002, British Journal of Nutrition.

[11]  C. Field,et al.  The immune-enhancing effects of dietary fibres and prebiotics , 2002, British Journal of Nutrition.

[12]  J. Gordon,et al.  How host-microbial interactions shape the nutrient environment of the mammalian intestine. , 2002, Annual review of nutrition.

[13]  N. Petrovsky.  Towards a unified model of neuroendocrine–immune interaction , 2001, Immunology and cell biology.

[14]  B. Deplancke,et al.  Microbial modulation of innate defense: goblet cells and the intestinal mucus layer. , 2001, The American journal of clinical nutrition.

[15]  R. Lorenz,et al.  The gastrointestinal ecosystem: a precarious alliance among epithelium, immunity and microbiota , 2001, Cellular microbiology.

[16]  J. Pluske,et al.  Dietary manipulation of enteric disease , 2001 .

[17]  R. Matteri,et al.  Neuroendocrine responses to stress. , 2000 .

[18]  R. Mackie,et al.  Developmental microbial ecology of the neonatal gastrointestinal tract. , 1999, The American journal of clinical nutrition.

[19]  R. Mackie,et al.  Gut Microbiology and growth-promoting antibiotics in swine , 1999 .

[20]  G. Tannock.  Modification of the Normal Microbiota by Diet, Stress, Antimicrobial Agents, and Probiotics , 1997 .

[21]  G R Gibson,et al.  Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. , 1995, The Journal of nutrition.