The physiological role of -adrenoceptors in the CNS:

Since the discovery of the classical MAO and DAO, knowledge of this field has con- siderably broadened. Similar enzymes have been discovered with different, and prob- ably very important, physiological roles, from the simple degradation of biologically-active amines to the formation of intramolecular crosslinks in elastin and collagen and, probably at various other levels, the regulation of cell-growth. Pharmacologists now need to check the activity of their drugs on these enzymes, to ascertain that they have no side effects on cell growth or connective tissue and to develop selective inhibitors. Reading list