CHANGES IN SERUM LEVELS OF AMINO ACIDS AS AN INDEX FOR PRE- AND POSTOPERATIVE NUTRITION MANAGEMENT IN VARIOUS HEPATIC DISEASES

Correlations between the morbid condition of liver cirrhosis and plasma free amino acids, immunoreactive insulin (IRI) or immunoreactive glucagon (IRG) were studied. The following results were obtained from two groups of patients with and without encephalopathy:1) The sum of branched-chain amino acids (BCAA) was closely related to KICG, Bil and NH3.2) There was a negative relation between the sum of AAA and KICG, whereas there was a positive relation between the sum of AAA and Bil or NH3.3) BCAA/AAA was closely related to KICG, NH3 and Bul, which were in turn related to cholesterol or albumin.The following results were obtained from the group without encephalopathy:1) There was a negative correlation between IRI and I-Leu, Leu or BCAA/AAA;2) There was a close correlation between IRG and I-Leu or BCAA.It was thus considered that BCAA and AAA showed a close correlation with liver function, being respectively specific for IRI, IRG and individual amino acids. Therefore pre- and postoperative determination of individual changes in BCAA and of changes in IRI and IRG may provide an important index for nutrition management.

[1]  R. Baldessarini,et al.  False neurotransmitters and hepatic failure. , 1971, Lancet.

[2]  J. Fischer,et al.  Plasma amino acid patterns in hepatic encephalopathy of differing etiology. , 1977, Gastroenterology.

[3]  L. Jefferson,et al.  Regulation by insulin of amino acid release and protein turnover in the perfused rat hemicorpus. , 1977, The Journal of biological chemistry.

[4]  S. Iwarson,et al.  GENETIC FACTORS IN THE DEVELOPMENT OF CHRONIC ACTIVE HEPATITIS , 1977, The Lancet.

[5]  P. Soeters,et al.  INSULIN, GLUCAGON, AMINOACID IMBALANCE, AND HEPATIC ENCEPHALOPATHY , 1976, The Lancet.

[6]  A. M. Ebeid,et al.  The effect of normalization of plasma amino acids on hepatic encephalopathy in man. , 1976, Surgery.

[7]  J. Fischer,et al.  The role of plasma amino acids in hepatic encephalopathy. , 1975, Surgery.

[8]  R. Wurtman,et al.  INSULIN, PLASMA AMINOACID IMBALANCE, AND HEPATIC COMA , 1975, The Lancet.

[9]  R. Parrilla,et al.  Effect of Glucagon: Insulin Ratios on Hepatic Metabolism , 1974, Diabetes.

[10]  Cummings Mc,et al.  Depletion of brain norepinephrine in acute hepatic coma. , 1974 .

[11]  R. Sherwin,et al.  Hyperglucagonemia in Laennec's cirrhosis. The role of portal-systemic shunting. , 1974, The New England journal of medicine.

[12]  I. Valverde,et al.  Elevated plasma glucagon levels in cirrhosis of the liver. , 1973, The New England journal of medicine.

[13]  R. Williams,et al.  PLASMA AND BRAIN TRYPTOPHAN CHANGES IN EXPERIMENTAL ACUTE HEPATIC FAILURE , 1973, Journal of neurochemistry.

[14]  R. Wurtman,et al.  Brain Serotonin Content: Physiological Regulation by Plasma Neutral Amino Acids , 1972, Science.

[15]  D. M. Rocha,et al.  Glucagon-stimulating activity of 20 amino acids in dogs. , 1972, The Journal of clinical investigation.

[16]  R. Unger.  Glucagon and the Insulin:Glucagon Ratio in Diabetes and Other Catabolic Illnesses , 1971, Diabetes.

[17]  W H Oldendorf,et al.  Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. , 1971, The American journal of physiology.

[18]  W. Blackard,et al.  Portal and Peripheral Vein Immunoreactive Insulin Concentrations Before and After Glucose Infusion , 1970, Diabetes.

[19]  O. Crofford,et al.  Glucose intolerance and insulin resistance in patients with liver disease. II. A study of etiologic factors and evaluation of insulin actions. , 1969, Archives of internal medicine.

[20]  V. Marks,et al.  Glucose tolerance and diabetes in chronic liver disease. , 1967, Lancet.

[21]  W. Coon,et al.  Altered clearance of free amino acids from plasma of patients with cirrhosis of the liver. , 1966, The Journal of surgical research.

[22]  R. Butcher,et al.  Gluconeogenesis in the perfused liver. The effects of fasting, alloxan diabetes, glucagon, epinephrine, adenosine 3',5'-monophosphate and insulin. , 1966, The American journal of medicine.

[23]  T. Chalmers,et al.  The plasma amino acids in patients with liver failure. , 1957, The Journal of laboratory and clinical medicine.