Energy discrimination for positron emission tomography using the time information of the first detected photons

The advantages of Time-of-Flight positron emission tomography (TOF-PET) have pushed the development of detectors with better time resolution. In particular, Silicon Photomultipliers (SiPM) have evolved tremendously in the past decade and arrays with a fully digital readout are the next logical step (dSiPM). New multi-timestamp methods use the precise time information of multiple photons to estimate the time of a PET event with greater accuracy, resulting in excellent time resolution. We propose a method which uses the same timestamps as the time estimator to perform energy discrimination, thus using data obtained within 5 ns of the beginning of the event. Having collected all the necessary information, the dSiPM could then be disabled for the remaining scintillation while dedicated electronics process the collected data. This would reduce afterpulsing as the SPAD would be turned off for several hundred nanoseconds, emptying the majority of traps. The proposed method uses a strategy based on subtraction and minimal electronics to reject energy below a selected threshold. This method achieves an error rate of less than 3% for photopeak discrimination (threshold at 400 keV) for dark count rates up to 100 cps/μm2, time-to-digital converter resolution up to 50 ps and a photon detection efficiency ranging from 10 to 70%.

[1]  Shingo Mandai,et al.  Time estimation with multichannel digital silicon photomultipliers , 2015, Physics in medicine and biology.

[2]  David Stoppa,et al.  A time of arrival estimator based on multiple timestamps for digital PET detectors , 2012, 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC).

[3]  A. Lacaita,et al.  Avalanche photodiodes and quenching circuits for single-photon detection. , 1996, Applied optics.

[4]  Réjean Fontaine,et al.  TDC Array Tradeoffs in Current and Upcoming Digital SiPM Detectors for Time-of-Flight PET , 2017, IEEE Transactions on Nuclear Science.

[5]  W. Moses,et al.  Measurements of the intrinsic rise times of common inorganic scintillators , 1999 .

[6]  Larissa Njejimana,et al.  Design of a Real-Time FPGA-Based Data Acquisition Architecture for the LabPET II: An APD-Based Scanner Dedicated to Small Animal PET Imaging , 2012, IEEE Transactions on Nuclear Science.

[7]  J. Corbeil,et al.  Measurements and Ray-Tracing Simulations of Light Spread in LSO Crystals , 2009, IEEE Transactions on Nuclear Science.

[8]  A. Tosi,et al.  Principles and features of Single Photon Avalanche Diode Arrays , 2007 .

[9]  W W Moses,et al.  High-performance electronics for time-of-flight PET systems. , 2013, Journal of instrumentation : an IOP and SISSA journal.

[10]  M. V. Nemallapudi,et al.  Single photon time resolution of state of the art SiPMs , 2016 .

[11]  Benjamin Frisch,et al.  Time of flight positron emission tomography towards 100ps resolution with L(Y)SO: An experimental and theoretical analysis , 2013 .

[12]  A. Blondel,et al.  Time of flight positron emission tomography towards 100 ps resolution with L ( Y ) SO : an experimental and theoretical analysis , 2017 .

[13]  I. H. Park,et al.  Precision measurement of the photon detection efficiency of silicon photomultipliers using two integrating spheres. , 2014, Optics express.

[14]  Paul Lecoq,et al.  Measurement of intrinsic rise times for various L(Y)SO and LuAG scintillators with a general study of prompt photons to achieve 10 ps in TOF-PET , 2016, Physics in medicine and biology.

[15]  M. V. Nemallapudi,et al.  State of the art timing in TOF-PET detectors with LuAG, GAGG and L(Y)SO scintillators of various sizes coupled to FBK-SiPMs , 2016 .

[16]  P. Jarron,et al.  On the comparison of analog and digital SiPM readout in terms of expected timing performance , 2015 .

[17]  F. Beekman,et al.  Optical simulation of monolithic scintillator detectors using GATE/GEANT4 , 2010, Physics in medicine and biology.

[18]  Caroline Paulin,et al.  Sherbrooke’s First 3D Digital SiPM: Measurements, Recommendations and Future Work , 2016 .

[19]  E Auffray,et al.  Time-Based Readout of a Silicon Photomultiplier (SiPM) for Time of Flight Positron Emission Tomography (TOF-PET) , 2011, IEEE Transactions on Nuclear Science.

[20]  Roger Lecomte,et al.  Modeling of Single Photon Avalanche Diode Array Detectors for PET Applications , 2014, IEEE Transactions on Nuclear Science.

[21]  Paul Lecoq,et al.  Development of new scintillators for medical applications , 2016 .

[22]  J. Varela,et al.  TOFPET 2: A high-performance circuit for PET time-of-flight , 2016 .

[23]  Paul Lecoq,et al.  Ultrafast emission from colloidal nanocrystals under pulsed X-ray excitation , 2016 .

[24]  R. Fontaine,et al.  Digital SPAD scintillation detector simulation flow to evaluate and minimize real-time requirements , 2016, 2016 IEEE-NPSS Real Time Conference (RT).

[25]  Craig S Levin,et al.  A new dual threshold time-over-threshold circuit for fast timing in PET , 2014, Physics in medicine and biology.

[26]  Réjean Fontaine,et al.  Design considerations for embedded real-time processing for 3D digital SiPMs with multiple TDCs , 2016, 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop (NSS/MIC/RTSD).

[27]  M. Conti Focus on time-of-flight PET: the benefits of improved time resolution , 2011, European Journal of Nuclear Medicine and Molecular Imaging.

[28]  Shingo Mandai,et al.  Energy estimation technique utilizing timing information for TOF-PET application , 2013, 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC).

[29]  M. Paganoni,et al.  Performance study of Philips digital silicon photomultiplier coupled to scintillating crystals , 2016 .

[30]  T. Frach,et al.  The digital silicon photomultiplier — Principle of operation and intrinsic detector performance , 2009, 2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC).

[31]  Rejean Fontaine,et al.  Implementation Study of Single Photon Avalanche Diodes (SPAD) in $0.8~\mu\hbox{m}$ HV CMOS Technology , 2015, IEEE Transactions on Nuclear Science.

[32]  A Gulinatti,et al.  Self-suppression of reset induced triggering in picosecond SPAD timing circuits. , 2007, The Review of scientific instruments.

[33]  C. Piemonte,et al.  Set-up and methods for SiPM Photo-Detection Efficiency measurements , 2016 .

[34]  S. Charlebois,et al.  Modeling of single photon avalanche diode array detectors for PET applications , 2011, 2011 IEEE Nuclear Science Symposium Conference Record.