Optoacoustic online control for laser cyclophotocoagulation

In this work, we show the capability of laser optoacoustics to localize the position of the ciliary body on enucleated porcine and rabbit eyes. Our findings correspond well with histological sections of the measured area. Different wavelengths for an optoacoustical detection system in combination with laser cyclophotocoagulation have been compared taking grayscale images of the region of interest of rabbit and porcine eyes for various wavelengths in the NIR spectral range. Additionally, the changes in the optical properties of the tissue induced by coagulation with a diode laser were observed. First online measurements of the changes due to coagulation show that the method of laser optoacoustics is suitable for an online therapy control system.

[1]  John A. Stanturf,et al.  Where are we and how did we get here , 2003 .

[2]  Holger Lubatschowski,et al.  Characterization of tissuelike media using the photoacoustic method , 1998, European Conference on Biomedical Optics.

[3]  Kirill V. Larin,et al.  Monitoring of temperature distribution in tissues with optoacoustic technique in real time , 2000, BiOS.

[4]  Paul C. Beard,et al.  Optical detection system for biomedical photoacoustic imaging , 2000, BiOS.

[5]  Alexander A. Oraevsky,et al.  Ultimate sensitivity of time-resolved optoacoustic detection , 2000, BiOS.

[6]  H. G. Rylander,et al.  Optical model for light distribution during transscleral cyclophotocoagulation. , 1998, Applied optics.

[7]  H. G. Rylander,et al.  Optical properties of conjunctiva, sclera, and the ciliary body and their consequences for transscleral cyclophotocoagulation: erratum. , 1997, Applied optics.

[8]  Martin Frenz,et al.  Two-dimensional recording of optoacoustic waves , 1999, Photonics West - Biomedical Optics.

[9]  Ralf Brinkmann,et al.  Optoacoustic measurements during us irradiation of the retinal pigment epithelium , 2000, Photonics West - Biomedical Optics.

[10]  Holger Lubatschowski,et al.  Optoacoustical tissue differentiation for on-line therapy control , 2000, European Conference on Biomedical Optics.

[11]  A. Welch,et al.  Optical properties of conjunctiva, sclera, and the ciliary body and their consequences for transscleral cyclophotocoagulation. , 1996, Applied optics.

[12]  Alexander A. Oraevsky,et al.  Optoacoustic tomography of breast cancer with arc-array transducer , 2000, BiOS.

[13]  J. Mastrobattista,et al.  Ciliary body ablation: where are we and how did we get here? , 1996, Survey of ophthalmology.

[14]  Kirill V. Larin,et al.  Real-time optoacoustic monitoring during thermotherapy , 2000, BiOS.

[15]  Alexander A. Oraevsky,et al.  Noninvasive detection and staging of oral cancer in vivo with confocal optoacoustic tomography , 2000, BiOS.

[16]  F. D. de Mul,et al.  Image reconstruction for photoacoustic scanning of tissue structures. , 2000, Applied optics.

[17]  R. Esenaliev,et al.  Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors , 1999 .