Massively parallel CRISPR off-target detection enables rapid off-target prediction model building.
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Hongxian Xie | R. Tian | Chen Cao | Zhaoyue Huang | Dirong Dong | Yongfeng Hong | Yuyan Wang | Lifang Li | Zheng Hu | Jiashu Liu | Zheying Huang | Ye Chen | Chaoyue Zhong | Z. Jin | Dan He | Lili Sun | Tingting Zhao
[1] Zheng Hu,et al. FrCas9 is a CRISPR/Cas9 system with high editing efficiency and fidelity , 2022, Nature Communications.
[2] Suchita P. Nety,et al. The widespread IS200/IS605 transposon family encodes diverse programmable RNA-guided endonucleases , 2021, Science.
[3] E. Koonin,et al. Programmable RNA targeting with the single-protein CRISPR effector Cas7-11 , 2021, Nature.
[4] Ciaran M Lee,et al. Tools for experimental and computational analyses of off-target editing by programmable nucleases , 2020, Nature Protocols.
[5] A. Kernytsky,et al. Evaluation of Homology-Independent CRISPR-Cas9 Off-Target Assessment Methods , 2020, The CRISPR journal.
[6] J. Sagartz,et al. CRISPR-Cas9 gene editing of hepatitis B virus in chronically infected humanized mice , 2020, Molecular therapy. Methods & clinical development.
[7] P. Debata,et al. An effective vaginal gel to deliver CRISPR/Cas9 system encapsulated in poly (β-amino ester) nanoparticles for vaginal gene therapy , 2020, EBioMedicine.
[8] Ruochi Zhang,et al. CHANGE-seq reveals genetic and epigenetic effects on CRISPR-Cas9 genome-wide activity , 2020, Nature Biotechnology.
[9] Zhaolei Zhang,et al. CRISPR‐Net: A Recurrent Convolutional Network Quantifies CRISPR Off‐Target Activities with Mismatches and Indels , 2020, Advanced Science.
[10] Wen Xue,et al. Advances in CRISPR/Cas-based Gene Therapy in Human Genetic Diseases , 2020, Theranostics.
[11] Dipali G. Sashital,et al. CRISPR-Cas12a has widespread off-target and dsDNA-nicking effects , 2020, The Journal of Biological Chemistry.
[12] P. Debata,et al. Hyperbranched poly(β-amino ester) based polyplex nanopaticles for delivery of CRISPR/Cas9 system and treatment of HPV infection associated cervical cancer. , 2020, Journal of controlled release : official journal of the Controlled Release Society.
[13] Stan J. J. Brouns,et al. Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants , 2019, Nature Reviews Microbiology.
[14] Luca Pinello,et al. CRISPRitz: rapid, high-throughput and variant-aware in silico off-target site identification for CRISPR genome editing , 2019, Bioinform..
[15] Michael P Snyder,et al. Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements , 2019, Nature Communications.
[16] Xiangdong Wang,et al. Off-target genome editing: A new discipline of gene science and a new class of medicine , 2019, Cell Biology and Toxicology.
[17] Emanuel J. V. Gonçalves,et al. Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens , 2019, Nature.
[18] You Lu,et al. Advancements and Obstacles of CRISPR-Cas9 Technology in Translational Research , 2019, Molecular therapy. Methods & clinical development.
[19] F. Bushman,et al. iGUIDE: an improved pipeline for analyzing CRISPR cleavage specificity , 2019, Genome Biology.
[20] Charles D. Yeh,et al. Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq , 2018, Science.
[21] Daesik Kim,et al. DIG-seq: a genome-wide CRISPR off-target profiling method using chromatin DNA , 2018, Genome research.
[22] Tyler J. Reich,et al. Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells , 2018, Nature.
[23] Tao Zhang,et al. CRISPRMatch: An Automatic Calculation and Visualization Tool for High-throughput CRISPR Genome-editing Data Analysis , 2018, International journal of biological sciences.
[24] Jia Gu,et al. fastp: an ultra-fast all-in-one FASTQ preprocessor , 2018, bioRxiv.
[25] R. Weiss,et al. Human oncogenic viruses: nature and discovery , 2017, Philosophical Transactions of the Royal Society B: Biological Sciences.
[26] A. Bassuk,et al. Unexpected mutations after CRISPR–Cas9 editing in vivo , 2017, Nature Methods.
[27] J. Joung,et al. CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR-Cas9 nuclease off-targets , 2017, Nature Methods.
[28] Erik L. G. Wernersson,et al. BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks , 2017, Nature Communications.
[29] Leslie S. Edwards,et al. Mapping the genomic landscape of CRISPR–Cas9 cleavage , 2017, Nature Methods.
[30] J. Doudna,et al. Cornerstones of CRISPR–Cas in drug discovery and therapy , 2016, Nature Reviews Drug Discovery.
[31] Jin-Wu Nam,et al. In vivo high-throughput profiling of CRISPR–Cpf1 activity , 2016, Nature Methods.
[32] M. Plummer,et al. Global burden of cancers attributable to infections in 2012: a synthetic analysis. , 2016, The Lancet. Global health.
[33] Jin-Soo Kim,et al. Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells , 2016, Nature Biotechnology.
[34] Martin J. Aryee,et al. Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells , 2016, Nature Biotechnology.
[35] Max A. Horlbeck,et al. Nucleosomes impede Cas9 access to DNA in vivo and in vitro , 2016, eLife.
[36] Jin-Soo Kim,et al. Genome-wide target specificities of CRISPR-Cas9 nucleases revealed by multiplex Digenome-seq , 2016, Genome research.
[37] Meagan E. Sullender,et al. Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 , 2015, Nature Biotechnology.
[38] Xiao-Hui Zhang,et al. Off-target Effects in CRISPR/Cas9-mediated Genome Engineering , 2015, Molecular therapy. Nucleic acids.
[39] A. Regev,et al. Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System , 2015, Cell.
[40] Honglin Chen,et al. CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells. , 2015, The Journal of general virology.
[41] Changyu Wang,et al. TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy. , 2015, The Journal of clinical investigation.
[42] Martin J. Aryee,et al. GUIDE-Seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases , 2014, Nature Biotechnology.
[43] Akash Kumar,et al. MIPgen: optimized modeling and design of molecular inversion probes for targeted resequencing , 2014, Bioinform..
[44] M. Rowicka,et al. Nucleotide-resolution DNA double-strand breaks mapping by next-generation sequencing , 2013, Nature Methods.
[45] Marcel Martin. Cutadapt removes adapter sequences from high-throughput sequencing reads , 2011 .
[46] C. Wheeler,et al. HPV genotypes: implications for worldwide cervical cancer screening and vaccination. , 2010, The Lancet. Oncology.
[47] Alexander A. Sousa,et al. Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs , 2017, Nature Biomedical Engineering.
[48] S. Salzberg,et al. FLASH: fast length adjustment of short reads to improve genome assemblies , 2011, Bioinform..
[49] Claude-Alain H. Roten,et al. Fast and accurate short read alignment with Burrows–Wheeler transform , 2009, Bioinform..