Establishment and functional validation of a structural homology model for human DNA methyltransferase 1.

[1]  B. Saunders,et al.  358. Toxic fluorine compounds containing the C–F link. Part I. Methyl Fluoroacetate and Related Compounds , 1948 .

[2]  Richard Hurwitz,et al.  Characterization of a leukemic cell line of the pre‐B phenotype , 1979, International journal of cancer.

[3]  A. Razin,et al.  Substrate and sequence specificity of a eukaryotic DNA methylase , 1982, Nature.

[4]  V. Ingram,et al.  Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[5]  D. Santi,et al.  Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[6]  H. Leonhardt,et al.  A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei , 1992, Cell.

[7]  Rudolf Jaenisch,et al.  Targeted mutation of the DNA methyltransferase gene results in embryonic lethality , 1992, Cell.

[8]  J. Thornton,et al.  PROCHECK: a program to check the stereochemical quality of protein structures , 1993 .

[9]  Xiaodong Cheng,et al.  The DNA (cytosine-5) methyltransferases , 1994, Nucleic Acids Res..

[10]  R. Roberts,et al.  Hhal methyltransferase flips its target base out of the DNA helix , 1994, Cell.

[11]  J. Thompson,et al.  CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. , 1994, Nucleic acids research.

[12]  W. Lipscomb,et al.  The crystal structure of Haelll methyltransferase covalently complexed to DNA: An extrahelical cytosine and rearranged base pairing , 1995, Cell.

[13]  J. Scott Dixon,et al.  Flexible ligand docking using a genetic algorithm , 1995, J. Comput. Aided Mol. Des..

[14]  H. Ng,et al.  Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1. , 1997, Science.

[15]  David S. Goodsell,et al.  Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function , 1998 .

[16]  E. Li,et al.  Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases , 1998, Nature Genetics.

[17]  D. Haber,et al.  DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development , 1999, Cell.

[18]  A. Wolffe,et al.  DNA methylation in health and disease , 2000, Nature Reviews Genetics.

[19]  T. Bestor,et al.  The DNA methyltransferases of mammals. , 2000, Human molecular genetics.

[20]  J. Herman,et al.  DNA hypermethylation in tumorigenesis: epigenetics joins genetics. , 2000, Trends in genetics : TIG.

[21]  T. Bestor,et al.  Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA. , 2001, Nucleic acids research.

[22]  Peter A. Jones,et al.  The fundamental role of epigenetic events in cancer , 2002, Nature Reviews Genetics.

[23]  J. Weber,et al.  Review of the clinical experience with 5-azacytidine and 5-aza-2'-deoxycytidine in solid tumors. , 2002, Current opinion in investigational drugs.

[24]  J. Christman,et al.  5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy , 2002, Oncogene.

[25]  Rachel Jones,et al.  Behavioural genetics: Worms gang up on bacteria , 2002, Nature Reviews Genetics.

[26]  A. Bird.  DNA methylation patterns and epigenetic memory. , 2002, Genes & development.

[27]  H. Döhner,et al.  Capillary electrophoretic analysis of genomic DNA methylation levels. , 2003, Nucleic acids research.

[28]  M. Robert,et al.  DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells , 2003, Nature Genetics.

[29]  M. Muller,et al.  Endogenous Assays of DNA Methyltransferases: Evidence for Differential Activities of DNMT1, DNMT2, and DNMT3 in Mammalian Cells In Vivo , 2003, Molecular and Cellular Biology.