Thinking big about small beings--the (yet) underdeveloped microbial natural products chemistry in Brazil.

Covering: up to 2013. Natural products isolated from microorganisms from Brazil are comprehensively reviewed, including the microbial sources, bioactivities and biosynthesis. Analysis of trends related to the research on microbial natural products in Brazil is discussed in detail. An outlook to future perspectives of research in Brazil is presented considering the development of state-of-the-art strategies and approaches that have emerged during the last decade, aiming to investigate and better understand the microbial world and its chemical and biochemical capabilities. Finally, the importance of microbial natural products biodiscovery is discussed in the context of the BIOTA-FAPESP program in Brazil.

[1]  T. Zucchi,et al.  Isolation and Characterization of Phytotoxic Compounds Produced by Streptomyces sp. AMC 23 from Red Mangrove (Rhizophora mangle) , 2013, Applied Biochemistry and Biotechnology.

[2]  L. Wade.  Biodiversity. The Amazon in 4D. , 2013, Science.

[3]  A. Ferreira,et al.  Two Polyketides from a Co-culture of Two Marine-derived Fungal Strains , 2013 .

[4]  I. S. Melo,et al.  Bioassay-Guided Isolation of a Low Molecular Weight PHB from Burkholderia sp. with Phytotoxic Activity , 2013, Applied Biochemistry and Biotechnology.

[5]  N. Nanayakkara,et al.  In vitro anti-allergic activity of the fungal metabolite pyridovericin. , 2013, International immunopharmacology.

[6]  M. D. F. Matos,et al.  Cytotoxic evaluation of phenolic compounds from lichens against melanoma cells. , 2013, Chemical & pharmaceutical bulletin.

[7]  L. F. Alves.  Production of Phytotherapeutics in Brazil: History, Problems and Perspectives , 2013 .

[8]  W. L. Araújo,et al.  Endophytic fungi from Vitis labrusca L. ('Niagara Rosada') and its potential for the biological control of Fusarium oxysporum. , 2012, Genetics and molecular research : GMR.

[9]  A. Cruz,et al.  Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum , 2012 .

[10]  N. Lima,et al.  Filamentous fungi from the Atlantic marine sponge Dragmacidon reticulatum , 2012, Archives of Microbiology.

[11]  J. Rosenthal,et al.  The impact of the United Nations Convention on Biological Diversity on natural products research. , 2012, Natural product reports.

[12]  P. Jimenez,et al.  Cytotoxic Activity of Fungal Strains Isolated from the Ascidian Eudistoma vannamei , 2012, Chemistry & biodiversity.

[13]  A. Ferreira,et al.  Biosynthesis of two dihydropyrrole-polyketides from a marine-derived Penicillium citrinum , 2012 .

[14]  N. Lopes,et al.  Meroterpenes isolated from the endophytic fungus Guignardia mangiferae , 2012 .

[15]  Anita J. Marsaioli,et al.  Epicolactone – Natural Product Isolated from the Sugarcane Endophytic Fungus Epicoccum nigrum , 2012 .

[16]  E. Jones,et al.  Marine Fungi: and Fungal-like Organisms , 2012 .

[17]  J. Azevedo,et al.  Phylogenetic diversity of endophytic leaf fungus isolates from the medicinal tree Trichilia elegans (Meliaceae). , 2012, Genetics and molecular research : GMR.

[18]  E. R. Filho,et al.  Evaluation of Herbicidal Potential of Depsides from Cladosporium uredinicola, an Endophytic Fungus Found in Guava Fruit , 2012 .

[19]  D. L. Hawksworth.  Global species numbers of fungi: are tropical studies and molecular approaches contributing to a more robust estimate? , 2012, Biodiversity and Conservation.

[20]  Bas E. Dutilh,et al.  Taxonomic and Functional Microbial Signatures of the Endemic Marine Sponge Arenosclera brasiliensis , 2012, PloS one.

[21]  Rodolfo Paranhos,et al.  Abrolhos Bank Reef Health Evaluated by Means of Water Quality, Microbial Diversity, Benthic Cover, and Fish Biomass Data , 2012, PloS one.

[22]  E. Stewart.  Growing Unculturable Bacteria , 2012, Journal of bacteriology.

[23]  M. Cavalcanti,et al.  Diversity of leaf endophytic fungi in mangrove plants of northeast Brazil , 2012, Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology].

[24]  J. A. Pamphile,et al.  Chemical characterization of bioactive compounds from the endophytic fungus Diaporthe helianthi isolated from Luehea divaricata , 2012, Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology].

[25]  Nuno Bandeira,et al.  Mass spectral molecular networking of living microbial colonies , 2012, Proceedings of the National Academy of Sciences.

[26]  G. Straatsma,et al.  Macrofungal diversity in Colombian Amazon forests varies with regions and regimes of disturbance , 2012, Biodiversity and Conservation.

[27]  L. F. C. Coradello,et al.  Evaluating methods for the isolation of marine-derived fungal strains and production of bioactive secondary metabolites , 2012 .

[28]  I. S. Melo,et al.  Endophytic and rhizospheric bacteria from Opuntia ficus-indica mill and their ability to promote plant growth in cowpea, Vigna unguiculata (L.) Walp , 2012 .

[29]  J. A. Jorge,et al.  The fungal metabolite eugenitin as additive for Aspergillus niveus glucoamylase activation , 2012 .

[30]  J. Takahashi,et al.  Chemical and molecular characterization of Phomopsis and Cytospora-like endophytes from different host plants in Brazil. , 2012, Fungal biology.

[31]  T. Lotufo,et al.  Studies on the Secondary Metabolites of a Pseudoalteromonas sp. Isolated from Sediments Collected at the Northeastern Coast of Brazil , 2012, Chemistry & biodiversity.

[32]  N. Lopes,et al.  Systematic UPLC-ESI-MS/MS study on the occurrence of staurosporine and derivatives in associated marine microorganisms from Eudistoma vannamei , 2012 .

[33]  E. R. Filho,et al.  An antimicrobial alkaloid and other metabolites produced by Penicillium sp. An endophytic fungus isolated from Mauritia flexuosa L. f. , 2012 .

[34]  M. Mazzola,et al.  Diversity and natural functions of antibiotics produced by beneficial and plant pathogenic bacteria. , 2012, Annual review of phytopathology.

[35]  K. Nelson,et al.  Genomics Applications for the Developing World , 2012, Advances in Microbial Ecology.

[36]  Benjamin L Turner,et al.  Fungal Community Composition in Neotropical Rain Forests: the Influence of Tree Diversity and Precipitation , 2011, Microbial Ecology.

[37]  Hong-yu Zhang,et al.  Historical Variation of Structural Novelty in a Natural Product Library , 2011, Chemistry & biodiversity.

[38]  Rohit Ghai,et al.  Metagenomics of the Water Column in the Pristine Upper Course of the Amazon River , 2011, PloS one.

[39]  P. Dorrestein,et al.  Imaging mass spectrometry in microbiology , 2011, Nature Reviews Microbiology.

[40]  E. Jones,et al.  Fifty years of marine mycology , 2011, Fungal Diversity.

[41]  Juliana Fonseca Moreira da Silva,et al.  DIVERSITY AND ANTIMICROBIAL ACTIVITIES OF ENDOPHYTIC FUNGI ISOLATED FROM MYRCIA SELLOWIANA IN TOCANTINS, BRAZIL , 2011 .

[42]  E. Jones.  Are there more marine fungi to be described? , 2011 .

[43]  C. Rosa,et al.  Antifungal activity of trichothecenes from Fusarium sp. against clinical isolates of Paracoccidioides brasiliensis , 2011, Mycoses.

[44]  Michael Spiteller,et al.  Are we ready for industrial production of bioactive plant secondary metabolites utilizing endophytes? , 2011, Natural product reports.

[45]  Yit-Heng Chooi,et al.  Metabolic engineering for the production of natural products. , 2011, Annual review of chemical and biomolecular engineering.

[46]  I. G. Collado,et al.  Azaphilones from the endophyte Chaetomium globosum. , 2011, Journal of natural products.

[47]  E. Rodrigues-Fo,et al.  Dicitrinol, a Citrinin Dimer, Produced by Penicillium janthinellum , 2011 .

[48]  C. Souza-Motta,et al.  Endophytic fungi from the medicinal plant Lippia sidoides Cham. and their antimicrobial activity , 2011, Symbiosis.

[49]  D. Kingston.  Modern natural products drug discovery and its relevance to biodiversity conservation. , 2011, Journal of natural products.

[50]  C. Hertweck,et al.  Genomics-inspired discovery of natural products. , 2011, Current opinion in chemical biology.

[51]  P. de Vos,et al.  Vibrio communis sp. nov., isolated from the marine animals Mussismilia hispida, Phyllogorgia dilatata, Palythoa caribaeorum, Palythoa variabilis and Litopenaeus vannamei. , 2011, International journal of systematic and evolutionary microbiology.

[52]  R. Peixoto,et al.  Microbial Diversity of a Brazilian Coastal Region Influenced by an Upwelling System and Anthropogenic Activity , 2011, PloS one.

[53]  M. Rateb,et al.  Secondary metabolites of fungi from marine habitats. , 2011, Natural product reports.

[54]  Axel A Brakhage,et al.  Fungal secondary metabolites - strategies to activate silent gene clusters. , 2011, Fungal genetics and biology : FG & B.

[55]  M. Pupo,et al.  Biosynthesis of aphidicolin proceeds via the mevalonate pathway in the endophytic fungus Nigrospora sphaerica , 2011 .

[56]  Jesús Martín,et al.  Current approaches to exploit actinomycetes as a source of novel natural products , 2011, Journal of Industrial Microbiology & Biotechnology.

[57]  Wenjun Li,et al.  Biodiversity, bioactive natural products and biotechnological potential of plant-associated endophytic actinobacteria , 2011, Applied Microbiology and Biotechnology.

[58]  C. Pessoa,et al.  Chemical Constituents of Papulaspora immersa, an Endophyte from Smallanthus sonchifolius (Asteraceae), and Their Cytotoxic Activity , 2010, Chemistry & biodiversity.

[59]  W. Fenical,et al.  Antibacterials from the sea. , 2010, Chemistry.

[60]  David E. Williams,et al.  Use of experimental design for the optimization of the production of new secondary metabolites by two Penicillium species. , 2010, Journal of natural products.

[61]  L. Loguercio,et al.  Endophytic fungal diversity in Theobroma cacao (cacao) and T. grandiflorum (cupuaçu) trees and their potential for growth promotion and biocontrol of black-pod disease. , 2010, Fungal biology.

[62]  Anne Osbourn,et al.  Secondary metabolic gene clusters: evolutionary toolkits for chemical innovation. , 2010, Trends in genetics : TIG.

[63]  R. Berlinck,et al.  Sesquiterpenes from Xylaria sp., an endophytic fungus associated with Piper aduncum (Piperaceae) , 2010 .

[64]  G. Muricy,et al.  Isolation, characterization and phylogeny of sponge-associated bacteria with antimicrobial activities from Brazil. , 2010, Research in microbiology.

[65]  Ian Joint,et al.  Culturing marine bacteria – an essential prerequisite for biodiscovery , 2010, Microbial biotechnology.

[66]  Luís G. Dias,et al.  Diketopiperazines produced by endophytic fungi found in association with two Asteraceae species. , 2010, Phytochemistry.

[67]  R. Berlinck,et al.  Microbial diversity associated with algae, ascidians and sponges from the north coast of São Paulo state, Brazil. , 2010, Microbiological research.

[68]  K. Lewis,et al.  Uncultured microorganisms as a source of secondary metabolites , 2010, The Journal of Antibiotics.

[69]  C. Haddad,et al.  Biodiversity Conservation Research, Training, and Policy in São Paulo , 2010, Science.

[70]  N. Lopes,et al.  Fungal tyrosine betaine, a novel secondary metabolite from conidia of entomopathogenic Metarhizium spp. fungi. , 2010, Fungal biology.

[71]  F. Pavan,et al.  Antimycobacterial activity of lichen substances. , 2010, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[72]  J. Takahashi,et al.  Cytosporones O, P and Q from an endophytic Cytospora sp. , 2010 .

[73]  P. Proksch,et al.  Fungal endophytes from higher plants: a prolific source of phytochemicals and other bioactive natural products , 2010, Fungal Diversity.

[74]  L. Pfenning,et al.  Fungal endophytes associated with the mistletoe Phoradendron perrottettii and its host tree Tapirira guianensis , 2010, Mycological Progress.

[75]  R. G. Taketani,et al.  Diversity and identification of methanogenic archaea and sulphate-reducing bacteria in sediments from a pristine tropical mangrove , 2010, Antonie van Leeuwenhoek.

[76]  J. Takahashi,et al.  Austin, dehydroaustin and other metabolites from Penicillium brasilianum , 2010 .

[77]  M. C. M. Young,et al.  Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum (piperaceae) , 2010 .

[78]  L. S. Amaral,et al.  Two novel eremophilane sesquiterpenes from an endophytic Xylariaceous fungus isolated from leaves of Cupressus lusitanica , 2010 .

[79]  J. Carvalho,et al.  In vitro Antitumour Activity of Orsellinates , 2010, Zeitschrift fur Naturforschung. C, Journal of biosciences.

[80]  J. A. Pamphile,et al.  Evaluation of foliar fungal endophyte diversity and colonization of medicinal plant Luehea divaricata (Martius et Zuccarini). , 2010, Biological research.

[81]  W. Vilegas,et al.  Lichen Metabolites Modulate Hydrogen Peroxide and Nitric Oxide in Mouse Macrophages , 2009, Zeitschrift fur Naturforschung. C, Journal of biosciences.

[82]  A. Pomini,et al.  Long-chain acyl-homoserine lactones from Methylobacterium mesophilicum: synthesis and absolute configuration. , 2009, Journal of natural products.

[83]  V. Bolzani,et al.  Bioactive Metabolites Produced by Penicillium sp.1 and sp.2, Two Endophytes Associated with Alibertia macrophylla (Rubiaceae) , 2009, Zeitschrift fur Naturforschung. C, Journal of biosciences.

[84]  Haruo Ikeda,et al.  Genomic basis for natural product biosynthetic diversity in the actinomycetes. , 2009, Natural product reports.

[85]  H. Jenke-Kodama,et al.  Evolution of metabolic diversity: insights from microbial polyketide synthases. , 2009, Phytochemistry.

[86]  M. E. Silva-Stenico,et al.  ANTIFUNGAL COMPOUND PRODUCED BY THE CASSAVA ENDOPHYTE Bacillus pumilus MAIIIM4A , 2009 .

[87]  G. Challis,et al.  New natural product biosynthetic chemistry discovered by genome mining. , 2009, Natural product reports.

[88]  A. Aguirre,et al.  Biodiversity and Human Health , 2009, EcoHealth.

[89]  E. Rodrigues-Filho,et al.  Co-Production of Bisphenylpropanoid Amides and Meroterpenes by an Endophytic Penicillium brasilianum Found in the Root Bark of Melia azedarach , 2009, Zeitschrift fur Naturforschung. C, Journal of biosciences.

[90]  D. Richardson,et al.  Influence of metal ions and organic carbons on denitrification activity of the halotolerant bacterium, Paracoccus pantotrophus P16 a strain from shrimp pond , 2009 .

[91]  L. Costa-Lotufo,et al.  Endophytic fungi found in association with Smallanthus sonchifolius (Asteraceae) as resourceful producers of cytotoxic bioactive natural products , 2009, Journal of basic microbiology.

[92]  U. Lins,et al.  Diversity of Bacteria in the Marine Sponge Aplysina fulva in Brazilian Coastal Waters , 2009, Applied and Environmental Microbiology.

[93]  A. Demain,et al.  Microbial drug discovery: 80 years of progress , 2009, The Journal of Antibiotics.

[94]  A. D. Buss,et al.  Natural product chemistry for drug discovery , 2009 .

[95]  Philip G. Williams,et al.  Panning for chemical gold: marine bacteria as a source of new therapeutics. , 2009, Trends in biotechnology.

[96]  J. Takahashi,et al.  Isolation and screening of fungal species isolated from Brazilian cerrado soil for antibacterial activity against Escherichia coli , Staphylococcus aureus , Salmonella typhimurium , Streptococcus pyogenes and Listeria monocytogenes , 2008 .

[97]  C. Rosa,et al.  Leishmanicidal Metabolites from Cochliobolus sp., an Endophytic Fungus Isolated from Piptadenia adiantoides (Fabaceae) , 2008, PLoS neglected tropical diseases.

[98]  N. K. Honda,et al.  Radical-scavenging activity of orsellinates. , 2008, Chemical & pharmaceutical bulletin.

[99]  L. Bonjardim,et al.  Purification, physicochemical properties, thermal analysis and antinociceptive effect of atranorin extracted from Cladina kalbii. , 2008, Biological & pharmaceutical bulletin.

[100]  J. Takahashi,et al.  Phthalates production from Curvularia senegalensis (Speg.) Subram, a fungal species associated to crops of commercial value. , 2008, Microbiological research.

[101]  C. Rosa,et al.  Altenusin, a biphenyl isolated from the endophytic fungus Alternaria sp., inhibits trypanothione reductase from Trypanosoma cruzi. , 2008, FEMS microbiology letters.

[102]  V. Verma,et al.  Isolation and identification of an endophytic strain of Fusarium oxysporum producing podophyllotoxin from Juniperus recurva , 2008 .

[103]  C. Silveira,et al.  Bacterial communities of the marine sponges Hymeniacidon heliophila and Polymastia janeirensis and their environment in Rio de Janeiro, Brazil , 2008 .

[104]  R. Corrêa-Oliveira,et al.  A potent trypanocidal component from the fungus Lentinus strigosus inhibits trypanothione reductase and modulates PBMC proliferation. , 2008, Memorias do Instituto Oswaldo Cruz.

[105]  A. Ventosa,et al.  Prokaryotic diversity in one of the largest hypersaline coastal lagoons in the world , 2008, Extremophiles.

[106]  E. Stocker-Wörgötter.  Metabolic diversity of lichen-forming ascomycetous fungi: culturing, polyketide and shikimate metabolite production, and PKS genes. , 2008, Natural product reports.

[107]  A. K. Calgarotto,et al.  Koninginins, phospholipase A2 inhibitors from endophytic fungus Trichoderma koningii. , 2008, Toxicon : official journal of the International Society on Toxinology.

[108]  N. K. Honda,et al.  Activities of 2,4-Dihydroxy-6-n-pentylbenzoic Acid Derivatives , 2008, Zeitschrift fur Naturforschung. C, Journal of biosciences.

[109]  B. Pfeifer,et al.  Bacterial hosts for natural product production. , 2008, Molecular pharmaceutics.

[110]  M. Spiteller,et al.  An endophytic fungus from Hypericum perforatum that produces hypericin. , 2008, Journal of natural products.

[111]  Luciano da Silva Momesso,et al.  Chaetoglobosinas produzidas por Chaetomium globosum, fungo endofítico associado a Viguiera robusta Gardn. (Asteraceae) , 2008 .

[112]  K. Zengler.  Accessing uncultivated microorganisms : from the environment to organisms and genomes and back , 2008 .

[113]  F. Henrique-Silva,et al.  A new guaiane mannoside from a Eutypa-like fungus isolated from Murraya paniculata in Brazil , 2008 .

[114]  Arnold L. Demain,et al.  Contributions of Microorganisms to Industrial Biology , 2008, Molecular biotechnology.

[115]  C. L. Silva,et al.  A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina , 2008 .

[116]  G. Oliva,et al.  Biological activities from extracts of endophytic fungi isolated from Viguiera arenaria and Tithonia diversifolia. , 2008, FEMS immunology and medical microbiology.

[117]  L. Roesch,et al.  Diversidade de bactérias diazotróficas endofíticas associadas a plantas de milho , 2007 .

[118]  J. Takahashi,et al.  Antimicrobial properties of sclerotiorin, isocHromophilone VI and pencolide, metabolites from a Brazilian cerrado isolate of Penicillium sclerotiorum van Beyma , 2007 .

[119]  Mônica Tallarico Pupo,et al.  BIOLOGIA QUÍMICA: UMA ESTRATÉGIA MODERNA PARA A PESQUISA EM PRODUTOS NATURAIS , 2007 .

[120]  W. L. Araújo,et al.  Diversity of Cultivated Endophytic Bacteria from Sugarcane: Genetic and Biochemical Characterization of Burkholderia cepacia Complex Isolates , 2007, Applied and Environmental Microbiology.

[121]  M. Saleem,et al.  Marine natural products of fungal origin. , 2007, Natural product reports.

[122]  S. Reed,et al.  Biogeochemical consequences of rapid microbial turnover and seasonal succession in soil. , 2007, Ecology.

[123]  J. Pielke.  The Honest Broker: Making Sense of Science in Policy and Politics , 2007 .

[124]  D. Hoffmeister,et al.  Natural products of filamentous fungi: enzymes, genes, and their regulation. , 2007, Natural product reports.

[125]  S. Tsai,et al.  Sporulation and diversity of arbuscular mycorrhizal fungi in Brazil Pine in the field and in the greenhouse , 2007, Mycorrhiza.

[126]  Renata Pastre,et al.  DIVERSIDADE DE POLICETÍDEOS PRODUZIDOS POR ESPÉCIES DE Penicillium ISOLADAS DE Melia azedarach E Murraya paniculata , 2007 .

[127]  Nduka Okafor,et al.  Modern Industrial Microbiology and Biotechnology , 2007 .

[128]  C. Costa-Neto,et al.  Aromatic compounds produced by Periconia atropurpurea, an endophytic fungus associated with Xylopia aromatica. , 2006, Phytochemistry.

[129]  Michael A Fischbach,et al.  New antibiotics from bacterial natural products , 2006, Nature Biotechnology.

[130]  G. Silva,et al.  Antifungal metabolites from Colletotrichum gloeosporioides, an endophytic fungus in Cryptocarya mandioccana Nees (Lauraceae) , 2006 .

[131]  W. Borges,et al.  Novel anthraquinone derivatives produced by Phoma sorghina, an endophyte found in association with the medicinal plant Tithonia diversifolia (Asteraceae) , 2006 .

[132]  R. Duran,et al.  Characterization of hydrocarbonoclastic bacterial communities from mangrove sediments in Guanabara Bay, Brazil. , 2006, Research in microbiology.

[133]  R. M. Muzzi,et al.  Cytotoxic Activity of Orsellinates , 2006, Zeitschrift fur Naturforschung. C, Journal of biosciences.

[134]  R. Tan,et al.  Biology and chemistry of endophytes. , 2006, Natural product reports.

[135]  M. Eberlin,et al.  Cadinane sesquiterpenoids of Phomopsis cassiae, an endophytic fungus associated with Cassia spectabilis (Leguminosae). , 2006, Phytochemistry.

[136]  C. Ireland,et al.  New Destruxins from the Marine-derived Fungus Beauveria felina , 2006, The Journal of Antibiotics.

[137]  J. R. Porter,et al.  Endophyte fungal isolates from Podophyllum peltatum produce podophyllotoxin. , 2006, Journal of natural products.

[138]  C. Pedrós-Alió,et al.  Marine microbial diversity: can it be determined? , 2006, Trends in microbiology.

[139]  Ben Shen,et al.  Microbial genomics for the improvement of natural product discovery. , 2006, Current opinion in microbiology.

[140]  C. Rosa,et al.  Cytotoxic, immunosuppressive and trypanocidal activities of agrocybin, a polyacetylene produced by Agrocybe perfecta (Basidiomycota) , 2006 .

[141]  T. Amna,et al.  The endophytic fungus Trametes hirsuta as a novel alternative source of podophyllotoxin and related aryl tetralin lignans. , 2006, Journal of biotechnology.

[142]  K. S. Lam,et al.  Drug discovery from natural products , 2006, Journal of Industrial Microbiology and Biotechnology.

[143]  A. Gunatilaka.  Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity, and implications of their occurrence. , 2006, Journal of natural products.

[144]  S. Kehraus,et al.  Natural Products from Marine Organisms and Their Associated Microbes , 2006, Chembiochem : a European journal of chemical biology.

[145]  G. Mueller,et al.  An estimate of the lower limit of global fungal diversity , 2006, Biodiversity and Conservation.

[146]  M. C. M. Young,et al.  Substâncias antifúngicas de Xylaria sp., um fungo endofítico isolado de Palicourea marcgravii (Rubiaceae) , 2005 .

[147]  M. Spiteller,et al.  An endophytic fungus from Nothapodytes foetida that produces camptothecin. , 2005, Journal of natural products.

[148]  A. Ferreira,et al.  C25 steroid epimers produced by Penicillium janthinellum, a fungus isolated from fruits Melia azedarach , 2005 .

[149]  M. Eberlin,et al.  New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis , 2005 .

[150]  I. Carvalho,et al.  Diketopiperazines produced by an Aspergillus fumigatus Brazilian strain , 2005 .

[151]  M. Eberlin,et al.  Benzopyrans from Curvularia sp., an endophytic fungus associated with Ocotea corymbosa (Lauraceae). , 2005, Phytochemistry.

[152]  E. Rodrigues-Filho,et al.  Lanostane triterpenes from the fungus Pisolithus tinctorius , 2005 .

[153]  Claudia Schmidt-Dannert,et al.  Current and Emerging Approaches for Natural Product Biosynthesis in Microbial Cells , 2005 .

[154]  E. Rodrigues-Filho,et al.  Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach , 2005 .

[155]  E. Rodrigues-Filho,et al.  Four spiroquinazoline alkaloids from Eupenicillium sp. isolated as an endophytic fungus from leaves of Murraya paniculata (Rutaceae) , 2005 .

[156]  János Bérdy,et al.  Bioactive microbial metabolites. , 2005, The Journal of antibiotics.

[157]  A. Demain,et al.  Natural products : drug discovery and therapeutic medicine , 2005 .

[158]  M. Fonseca,et al.  Antibacterial activity from Penicillium corylophilum Dierckx. , 2004, Microbiology Research.

[159]  G. Manfio,et al.  Investigation of bacterial diversity in Brazilian tropical estuarine sediments reveals high actinobacterial diversity , 2004, Antonie van Leeuwenhoek.

[160]  J. Rohr,et al.  DNA-binding properties of cosmomycin D, an anthracycline with two trisaccharide chains. , 2004, The Journal of antibiotics.

[161]  Karl-Erich Jaeger,et al.  Prospecting for biocatalysts and drugs in the genomes of non-cultured microorganisms. , 2004, Current opinion in biotechnology.

[162]  W. Vilegas,et al.  Intermediate reactive oxygen and nitrogen from macrophages induced by Brazilian lichens. , 2004, Fitoterapia.

[163]  A. Ferreira,et al.  Dipeptide metabolites from the marine derived bacterium Streptomyces acrymicini , 2004 .

[164]  M. Iacomini,et al.  Culture studies and secondary compounds of six Ramalina species. , 2004, Mycological research.

[165]  C. Ireland,et al.  Marine-derived fungi: a chemically and biologically diverse group of microorganisms. , 2004, Natural product reports.

[166]  C. Nunez,et al.  Challenges and rewards of research in marine natural products chemistry in Brazil. , 2004, Journal of natural products.

[167]  A. Marsaioli,et al.  Terreinol-a novel metabolite from Aspergillus terreus: structure and 13C labeling , 2004 .

[168]  G. Strobel,et al.  Bioprospecting for Microbial Endophytes and Their Natural Products , 2003, Microbiology and Molecular Biology Reviews.

[169]  S. Giovannoni,et al.  The uncultured microbial majority. , 2003, Annual review of microbiology.

[170]  Maria Francisca Simas Teixeira,et al.  Endophytic fungi from Melia azedarach , 2003 .

[171]  E. Rodrigues-Filho,et al.  Structures of meroterpenes produced by Penicillium sp, an endophytic fungus found associated with Melia azedarach , 2003 .

[172]  E. Rodrigues-Fo,et al.  Further Meroterpenes Produced by Penicillium sp., an Endophyte Obtained from Melia azedarach , 2003, Zeitschrift fur Naturforschung. C, Journal of biosciences.

[173]  D. Hughes,et al.  Diversifying microbial natural products for drug discovery , 2003, Applied Microbiology and Biotechnology.

[174]  C. Daolio,et al.  Three Highly Oxygenated Caryophyllene Sesquiterpenes from Pestalotiopsis sp., a Fungus Isolated from Bark of Pinus taeda , 2003, Zeitschrift für Naturforschung C - A Journal of Biosciences.

[175]  D. Hughes.  Microbial genetics: Exploiting genomics, genetics and chemistry to combat antibiotic resistance , 2003, Nature Reviews Genetics.

[176]  T. Mincer,et al.  Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora. , 2003, Angewandte Chemie.

[177]  A. Bull.  Microbial Diversity and Bioprospecting , 2003 .

[178]  E. Rodrigues-Fo,et al.  Meroterpenes from Penicillium sp found in association with Melia azedarach. , 2002, Phytochemistry.

[179]  F. Rohwer,et al.  Use of 16S Ribosomal DNA for Delineation of Marine Bacterioplankton Species , 2002, Applied and Environmental Microbiology.

[180]  Norberto Lopes,et al.  Produtos naturais: atualidade, desafios e perspectivas , 2002 .

[181]  Alphonse Kelecom,et al.  Secondary metabolites from marine microorganisms. , 2002, Anais da Academia Brasileira de Ciencias.

[182]  S. Said,et al.  The antimicrobial activity of Aspergillus fumigatus is enhanced by a pool of bacteria. , 2002, Microbiological research.

[183]  M. Hesse,et al.  Guignardic Acid, a Novel Type of Secondary Metabolite Produced by the Endophytic Fungus Guignardia sp.: Isolation, Structure Elucidation, and Asymmetric Synthesis , 2001 .

[184]  D. Hawksworth.  The magnitude of fungal diversity: the 1.5 million species estimate revisited * * Paper presented at , 2001 .

[185]  R. Tan,et al.  Endophytes: a rich source of functional metabolites. , 2001, Natural product reports.

[186]  Alan T. Bull,et al.  Search and Discovery Strategies for Biotechnology: the Paradigm Shift , 2000, Microbiology and Molecular Biology Reviews.

[187]  A. Magalhães,et al.  N-acetyl-gamma-hydroxyvaline lactone, an unusual amino acid derivative from a marine streptomycete. , 2000, Journal of Natural Products.

[188]  D. Hawksworth,et al.  Where are all the undescribed fungi? , 1997, Phytopathology.

[189]  A. Stierle,et al.  The search for a taxol-producing microorganism among the endophytic fungi of the Pacific yew, Taxus brevifolia. , 1995, Journal of natural products.

[190]  A. Stierle,et al.  Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew. , 1993, Science.

[191]  David L. Hawksworth,et al.  The fungal dimension of biodiversity: magnitude, significance, and conservation , 1991 .

[192]  Arnold L. Demain,et al.  Manual of Industrial Microbiology and Biotechnology , 1986 .

[193]  T. Macke,et al.  A phylogenetic definition of the major eubacterial taxa. , 1985, Systematic and applied microbiology.