Hereditary breast cancer: Pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage

The purpose of this investigation was to determine if there are pathobiologic differences between BRCA1‐related and BRCA2‐related hereditary breast cancer (HBC) and non‐HBC.

[1]  M. Province,et al.  Proliferative rate by S‐phase measurement may affect cure of breast carcinoma , 1995, Cancer.

[2]  David L. Page,et al.  Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression , 1995, Nature Genetics.

[3]  A. Whittemore,et al.  An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Breast Cancer Linkage Consortium. , 1995, American journal of human genetics.

[4]  A. Lawler.  New GOP Chairs Size Up Science. , 1994, Science.

[5]  L. Hartwell,et al.  Cell cycle control and cancer. , 1994, Science.

[6]  M. Skolnick,et al.  BRCA1 mutations in primary breast and ovarian carcinomas. , 1994, Science.

[7]  Steven E. Bayer,et al.  A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. , 1994, Science.

[8]  U. Chetty,et al.  Breast cancer incidence, penetrance and survival in probable carriers of BRCA1 gene mutation in families linked to BRCA1 on chromosome 17q12–21 , 1994, The British journal of surgery.

[9]  S. Seal,et al.  Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. , 1994, Science.

[10]  R. Nowak.  Breast cancer gene offers surprises. , 1994, Science.

[11]  K. McKenzie,et al.  Frequent p53 gene mutations and novel alleles in familial breast cancer. , 1994, Cancer research.

[12]  Å. Borg,et al.  High frequency of allelic imbalance at the BRCA1 region on chromosome 17q in both familial and sporadic ductal breast carcinomas. , 1994, Journal of the National Cancer Institute.

[13]  M. King,et al.  Familial male breast cancer is not linked to the BRCA1 locus on chromosome 17q , 1994, Nature Genetics.

[14]  D. Page,et al.  Pathology and heredity of breast cancer in younger women. , 1994, Journal of the National Cancer Institute. Monographs.

[15]  P. O'Connell,et al.  A breast-ovarian cancer susceptibility gene maps to chromosome 17q21. , 1993, American journal of human genetics.

[16]  D. Easton,et al.  Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium. , 1993, American journal of human genetics.

[17]  M. Pike,et al.  Hormonal chemoprevention of cancer in women , 1993, Science.

[18]  C. Steel,et al.  Breast cancer survival in BRCA1 carriers , 1993, The Lancet.

[19]  W. Thompson,et al.  Relationship between breast histopathology and family history of breast cancer , 1993, Cancer.

[20]  Y. Nakamura,et al.  Correlation of loss of alleles on the short arms of chromosomes 11 and 17 with metastasis of primary breast cancer to lymph nodes. , 1992, Cancer research.

[21]  H. Lynch,et al.  Hereditary Ovarian Cancer: A Clinicopathological Study , 1992, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[22]  V. Kosma,et al.  DNA flow cytometry, nuclear morphometry, mitotic indices and steroid receptors as independent prognostic factors in female breast cancer , 1992, International journal of cancer.

[23]  E. Kawasaki,et al.  Accumulation of p53 tumor suppressor gene protein: an independent marker of prognosis in breast cancers. , 1992, Journal of the National Cancer Institute.

[24]  V. Kosma,et al.  Nuclear morphometry and DNA flow cytometry as prognostic factors in female breast cancer. , 1992, The European journal of surgery = Acta chirurgica.

[25]  P. Devilee,et al.  Fractional allelic imbalance in human breast cancer increases with tetraploidization and chromosome loss , 1992, International journal of cancer.

[26]  R. Weinberg,et al.  Tumor suppressor genes. , 1991, Science.

[27]  Y. Nakamura,et al.  Accumulation of genetic alterations and progression of primary breast cancer. , 1991, Cancer research.

[28]  G. Lenoir,et al.  Familial breast-ovarian cancer locus on chromosome 17q12-q23 , 1991, The Lancet.

[29]  B. Ljung,et al.  Loss of heterozygosity on the short arm of chromosome 17 is associated with high proliferative capacity and DNA aneuploidy in primary human breast cancer. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[30]  M. Fernö,et al.  Proliferation and DNA ploidy in malignant breast tumors in relation to early oral contraceptive use and early abortions , 1991, Cancer.

[31]  S. Narod.  Counselling under genetic heterogeneity: a practical approach , 1991, Clinical genetics.

[32]  M. King,et al.  Linkage of early-onset familial breast cancer to chromosome 17q21. , 1990, Science.

[33]  M. Pike,et al.  Increased cell division as a cause of human cancer. , 1990, Cancer research.

[34]  L. Ellwein,et al.  Cell proliferation in carcinogenesis. , 1990, Science.

[35]  R. Camplejohn,et al.  DNA index, S-phase fraction, histological grade and prognosis in breast cancer. , 1990, British Journal of Cancer.

[36]  D. Visscher,et al.  Prognostic significance of morphological parameters and flow cytometric DNA analysis in carcinoma of the breast. , 1990, Pathology annual.

[37]  H. Magdelenat,et al.  Correlation of pretreatment proliferative activity of breast cancer with the response to cytotoxic chemotherapy. , 1989, Journal of the National Cancer Institute.

[38]  B. Modan,et al.  Histologic types of breast carcinoma in relation to international variation and breast cancer risk factors , 1989 .

[39]  S. Shackney,et al.  Model for the genetic evolution of human solid tumors. , 1989, Cancer research.

[40]  S. Shackney,et al.  Model for the genetic evolution of solid tumors , 1989 .

[41]  R. Zarbo,et al.  Flow cytometric DNA analysis of colon adenocarcinomas: a comparative study of preparatory techniques. , 1988, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

[42]  M. King,et al.  Inheritance of human breast cancer: evidence for autosomal dominant transmission in high-risk families. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[43]  J. Russo,et al.  Influence of age and gland topography on cell kinetics of normal human breast tissue. , 1987, Journal of the National Cancer Institute.

[44]  H. Lynch,et al.  Breast cancer genetics in an oncology clinic: 328 consecutive patients. , 1986, Cancer genetics and cytogenetics.

[45]  Robert W. McDivitt,et al.  A proposed classification of breast cancer based on kinetic information derived from a comparison of risk factors in 168 primary operable breast cancers , 1986, Cancer.

[46]  J. Meyer,et al.  Breast carcinoma cell kinetics, morphology, stage, and host characteristics. A thymidine labeling study. , 1986, Laboratory investigation; a journal of technical methods and pathology.

[47]  I W Taylor,et al.  Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. , 1983, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[48]  M. Pike,et al.  BREAST CANCER IN YOUNG WOMEN AND USE OF ORAL CONTRACEPTIVES: POSSIBLE MODIFYING EFFECT OF FORMULATION AND AGE AT USE , 1983, The Lancet.

[49]  William H. Hartmann,et al.  The World Health Organization Histological Typing of Breast Tumors—Second Edition , 1982 .

[50]  W. Kimberling,et al.  Natural history of hereditary cancer of the breast and colon , 1982, Cancer.

[51]  R. Senie,et al.  Epidemiology of breast carcinoma III relationship of family history to tumor type , 1982, Cancer.

[52]  S H Moolgavkar,et al.  Mutation and cancer: a model for human carcinogenesis. , 1981, Journal of the National Cancer Institute.

[53]  J. Kalbfleisch,et al.  The Statistical Analysis of Failure Time Data , 1980 .

[54]  Christine Betts,et al.  Tubular carcinoma: a variant of secretory breast carcinoma , 1979, Histopathology.

[55]  C. Redmond,et al.  Tubulolobular invasive breast cancer: a variant of lobular invasive cancer. , 1977, Human pathology.

[56]  P. Rosen,et al.  Medullary carcinoma of the breast. A clinicopathologic study with 10 year follow‐up , 1977, Cancer.

[57]  J. Meyer.  Cell proliferation in normal human breast ducts, fibroadenomas, and other ductal hyperplasias measured by nuclear labeling with tritiated thymidine. Effects of menstrual phase, age, and oral contraceptive hormones. , 1977, Human pathology.

[58]  D. Anderson.  Genetic study of breast cancer: Identification of a high risk group , 1974, Cancer.

[59]  Strother H. Walker,et al.  Estimation of the probability of an event as a function of several independent variables. , 1967, Biometrika.