Phosphoinositide metabolism, aging and Alzheimer's disease.

[1]  J. Jolles,et al.  Platelet phosphatidylinositol kinase activity is not altered in Alzheimer disease. , 1993, Molecular and chemical neuropathology.

[2]  J. Jolles,et al.  Brain phosphatidic acid and polyphosphoinositide formation in a broken cell preparation: Regional distribution and the effect of age , 1992, Neurochemistry International.

[3]  C. Hensey,et al.  The protein kinase C family. , 1992, European journal of biochemistry.

[4]  P. Janmey,et al.  Identification of a polyphosphoinositide-binding sequence in an actin monomer-binding domain of gelsolin. , 1992, The Journal of biological chemistry.

[5]  P. Hawkins,et al.  Platelet-derived growth factor stimulates synthesis of Ptdlns(3,4,5)P3 by activating a Ptdlns(4,5)P2 3-OH kinase , 1992, Nature.

[6]  C. Surridge,et al.  Phosphatidylinositol inhibits microtubule assembly by binding to microtubule-associated protein 2 at a single, specific, high-affinity site. , 1992, Biochemistry.

[7]  B. Winblad,et al.  Preservation of Gi-protein inhibited adenylyl cyclase activity in the brains of patients with Alzheimer's disease , 1992, Neuroscience Letters.

[8]  E. Friedman,et al.  Aging-induced decrease in dopaminergic-stimulated phosphoinositide metabolism in rat brain , 1992, Neurobiology of Aging.

[9]  S. Rhee,et al.  Regulation of inositol phospholipid-specific phospholipase C isozymes. , 1992, The Journal of biological chemistry.

[10]  J. Jolles,et al.  Phosphatidylinositol Kinase Is Reduced in Alzheimer's Disease , 1992, Journal of neurochemistry.

[11]  T. Taniguchi,et al.  Phosphatidylinositol-specific phospholipase C activity in the postmortem human brain: no alteration in Alzheimer's disease , 1992, Brain Research.

[12]  B. Winblad,et al.  Adenylyl Cyclase Activity in Postmortem Human Brain: Evidence of Altered G Protein Mediation in Alzheimer's Disease , 1992, Journal of neurochemistry.

[13]  C. Advokat,et al.  Excitatory amino acids and memory: Evidence from research on Alzheimer's disease and behavioral pharmacology , 1992, Neuroscience & Biobehavioral Reviews.

[14]  S. Iwashita,et al.  Signal transduction system for growth factor receptors associated with tyrosine kinase activity: epidermal growth factor receptor signalling and its regulation. , 1992, Cellular signalling.

[15]  J. Warsh,et al.  Inositol 1,4,5-trisphosphate receptor in developing and senescent rat cerebellum , 1992, Neurobiology of Aging.

[16]  C. Gelbmann,et al.  Chronic treatment with phosphatidylserine restores muscarinic cholinergic receptor deficits in the aged mouse brain , 1992, Neurobiology of Aging.

[17]  G. Johnson,et al.  Phosphorylation by cAMP-dependent protein kinase inhibits the degradation of tau by calpain. , 1992, The Journal of biological chemistry.

[18]  B. Agranoff,et al.  Inositol Lipids and Signal Transduction in the Nervous System: An Update , 1992, Journal of neurochemistry.

[19]  Y. Nishizuka,et al.  Protein kinase C in rat brain synaptosomes , 1991, FEBS letters.

[20]  B. Winblad,et al.  Preservation of 5-hydroxytryptamine1A receptor-G protein interactions in the cerebral cortex of patients with Alzheimer's disease , 1991, Neuroscience Letters.

[21]  R. Tanzi,et al.  Molecular genetics of Alzheimer disease amyloid. , 1991, The Journal of biological chemistry.

[22]  D. Hanger,et al.  A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilities. , 1991, The Biochemical journal.

[23]  J. Boonstra,et al.  Phosphoinositide kinase, diacylglycerol kinase, and phospholipase C activities associated to the cytoskeleton: effect of epidermal growth factor , 1991, The Journal of cell biology.

[24]  T. Taniguchi,et al.  Aberrant accumulation of phospholipase C-delta in Alzheimer brains. , 1991, The American journal of pathology.

[25]  B. Winblad,et al.  Regional distribution of somatostatin receptor binding and modulation of adenylyl cyclase activity in Alzheimer's disease brain , 1991, Journal of the Neurological Sciences.

[26]  E. Masliah,et al.  Protein kinase C alteration is an early biochemical marker in Alzheimer's disease , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[27]  H. Thaler,et al.  Inositol phosphates and intracellular calcium after bradykinin stimulation in fibroblasts from young, normal aged and Alzheimer donors , 1991, Neurobiology of Aging.

[28]  M. Plantavid,et al.  Interaction of pp60c-src, phospholipase C, inositol-lipid, and diacyglycerol kinases with the cytoskeletons of thrombin-stimulated platelets. , 1991, The Journal of biological chemistry.

[29]  B. Winblad,et al.  Somatostatin receptors and the modulation of adenylyl cyclase activity in Alzheimer's disease. , 1991, Journal of neurology, neurosurgery, and psychiatry.

[30]  D. F. Musto,et al.  Opium, cocaine and marijuana in American history. , 1991, Scientific American.

[31]  J. Price,et al.  The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease , 1991, Neurobiology of Aging.

[32]  J. Mcculloch,et al.  Robustness of G Proteins in Alzheimer's Disease: An Immunoblot Study , 1991, Journal of neurochemistry.

[33]  L. Cantley,et al.  Novel polyphosphoinositides in cell growth and activation. , 1991, Cancer cells.

[34]  L. Svennerholm,et al.  Membrane Lipids in the Aging Human Brain , 1991, Journal of neurochemistry.

[35]  J. Pettegrew,et al.  L‐Phosphoserine, a Metabolite Elevated in Alzheimer's Disease, Interacts with Specific L‐Glutamate Receptor Subtypes , 1991, Journal of Neurochemistry.

[36]  N. Cairns,et al.  Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated. , 1991, The Biochemical journal.

[37]  H. Tilson,et al.  Age-dependent changes in receptor-stimulated phosphoinositide turnover in the rat hippocampus , 1991, Pharmacology Biochemistry and Behavior.

[38]  E. Masliah,et al.  Altered Protein Tyrosine Phosphorylation in Alzheimer's Disease , 1991, Journal of neurochemistry.

[39]  G. Miner,et al.  Na+/Ca2+ exchange activity is increased in Alzheimer's disease brain tissues , 1991, Brain Research.

[40]  P. Galloway,et al.  Tropomyosin distinguishes Lewy bodies of Parkinson disease from other neurofibrillary pathology , 1991, Brain Research.

[41]  L. Hunyady,et al.  Second messengers derived from inositol lipids , 1991, Journal of bioenergetics and biomembranes.

[42]  G. Daley,et al.  Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants , 1991, Molecular and cellular biology.

[43]  A. Saltiel The role of glycosyl-phosphoinositides in hormone action , 1991, Journal of bioenergetics and biomembranes.

[44]  J. Bohl,et al.  Reduced basal and stimulated (isoprenaline, Gpp(NH)p, forskolin) adenylate cyclase activity in Alzheimer's disease correlated with histopathological changes , 1991, Brain Research.

[45]  L. Cantley,et al.  Oncogenes and signal transduction , 1991, Cell.

[46]  P. Wilce,et al.  Effects of chronic ethanol treatment and aging on brain phosphoinositide turnover and adenylate cyclase activity , 1990, Neurochemistry International.

[47]  J. Jolles,et al.  Phosphatidic acid and polyphosphoinositide formation in a broken cell preparation from rat brain: Effects of different incubation conditions , 1990, Neurochemistry International.

[48]  P. Majerus,et al.  Pathway for the formation of D-3 phosphate containing inositol phospholipids in intact human platelets. , 1990, The Journal of biological chemistry.

[49]  C. Taylor,et al.  The role of G proteins in transmembrane signalling. , 1990, The Biochemical journal.

[50]  L. Cantley,et al.  Purification and characterization of phosphoinositide 3-kinase from rat liver. , 1990, The Journal of biological chemistry.

[51]  C. Downes,et al.  myo-inositol metabolites as cellular signals. , 1990, European journal of biochemistry.

[52]  M. Trabucchi,et al.  Regulation of phorbol ester binding and protein kinase C activity in aged rat brain , 1990, Neurobiology of Aging.

[53]  T. Koyama,et al.  Membrane Viscosity Correlates with α1‐Adrenergic Signal Transduction of the Aged Rat Cerebral Cortex , 1990, Journal of neurochemistry.

[54]  E. Masliah,et al.  Differential involvement of protein kinase C isozymes in Alzheimer's disease , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[55]  A. Tanaka,et al.  Association of type I phosphatidylinositol kinase activity with mutationally activated forms of human pp60c-src , 1990, Molecular and cellular biology.

[56]  T. Oltersdorf,et al.  Cleavage of amyloid beta peptide during constitutive processing of its precursor. , 1990, Science.

[57]  J. Pettegrew,et al.  Changes in Brain Energy and Phospholipid Metabolism During Development and Aging in the Fischer 344 Rat , 1990, Journal of neuropathology and experimental neurology.

[58]  D. Price,et al.  Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. , 1990, Science.

[59]  N. Zahniser,et al.  Decreased efficacy of inositol 1,4,5-trisphosphate to elicit calcium mobilization from cerebrocortical microsomes of aged rats. , 1990, Molecular pharmacology.

[60]  S. Yen,et al.  Alzheimer disease proteins (A68) share epitopes with tau but show distinct biochemical properties , 1990, Journal of neuroscience research.

[61]  M. G. Low The glycosyl-phosphatidylinositol anchor of membrane proteins. , 1989, Biochimica et biophysica acta.

[62]  L. Dekker,et al.  Inhibition of noradrenaline release by antibodies to B-50 (GAP-43) , 1989, Nature.

[63]  E. El-Fakahany,et al.  Aging does not alter brain muscarinic receptor-mediated phosphoinositide hydrolysis and its inhibition by phorbol esters, tetrodotoxin and receptor desensitization. , 1989, The Journal of pharmacology and experimental therapeutics.

[64]  L. Cantley,et al.  Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain. , 1989, The Journal of biological chemistry.

[65]  Michael J. Berridge,et al.  Inositol phosphates and cell signalling , 1989, Nature.

[66]  R. Parthasarathy,et al.  The identification of a novel inositol lipid, phosphatidylinositol trisphosphate (PIP3), in rat cerebrum using in vivo techniques. , 1989, Biochemical and Biophysical Research Communications - BBRC.

[67]  Y. Henis,et al.  Aging of rat heart myocytes disrupts muscarinic receptor coupling that leads to inhibition of cAMP accumulation and alters the pathway of muscarinic-stimulated phosphoinositide hydrolysis. , 1989, Biochemistry.

[68]  G. Fisher,et al.  Isolation and characterization of one soluble and two membrane-associated forms of phosphoinositide-specific phospholipase C from human platelets. , 1989, Biochemistry.

[69]  S. Y. Lee,et al.  Studies of inositol phospholipid-specific phospholipase C. , 1989, Science.

[70]  P. Mulvihill,et al.  Immunoaffinity demonstration that paired helical filaments of Alzheimer disease share epitopes with neurofilaments, MAP2 and tau , 1989, Brain Research.

[71]  P. Libby,et al.  PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells , 1989, Cell.

[72]  R. Davis,et al.  Protein kinase C inhibition of the epidermal growth factor receptor tyrosine protein kinase activity is independent of the oligomeric state of the receptor. , 1989, The Journal of biological chemistry.

[73]  Kenneth S. Kosik,et al.  Developmentally regulated expression of specific tau sequences , 1989, Neuron.

[74]  P. Hawkins,et al.  Metabolic and structural evidence for the existence of a third species of polyphosphoinositide in cells: D-phosphatidyl-myo-inositol 3-phosphate. , 1989, The Biochemical journal.

[75]  E. Georges,et al.  Neurofilament Phosphorylation in Cultured Bovine Adrenal Chromaffin Cells Is Stimulated by Phorbol Ester , 1989, Journal of neurochemistry.

[76]  H. Hanafusa,et al.  Phosphatidylinositol kinase activity associates with viral p60src protein , 1989, Molecular and cellular biology.

[77]  K. Jellinger,et al.  Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease , 1989, Brain Research.

[78]  Hoau Yan Wang,et al.  Effect of Age on Brain Cortical Protein Kinase C and Its Mediation of 5‐Hydroxytryptamine Release , 1989, Journal of neurochemistry.

[79]  S. Kish,et al.  Decreased brain [3H]inositol 1,4,5-trisphosphate binding in Alzheimer's disease , 1988, Neuroscience Letters.

[80]  Y. Nishizuka,et al.  The molecular heterogeneity of protein kinase C and its implications for cellular regulation , 1988, Nature.

[81]  P. Taylor,et al.  An inositol tetrakisphosphate-containing phospholipid in activated neutrophils , 1988, Nature.

[82]  K. Dobkins,et al.  Decreased levels of protein kinase C in Alzheimer brain , 1988, Brain Research.

[83]  R. Nixon,et al.  Phosphorylation of neurofilament proteins by protein kinase C , 1988, FEBS letters.

[84]  L. Cantley,et al.  Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate , 1988, Nature.

[85]  G. Roth,et al.  Age-related impairment in rat parotid cell alpha 1-adrenergic action at the level of inositol trisphosphate responsiveness. , 1988, Biochimica et biophysica acta.

[86]  J. Baudier,et al.  Phosphorylation of tau proteins to a state like that in Alzheimer's brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids. , 1987, The Journal of biological chemistry.

[87]  J. Baudier,et al.  Separation of the different microtubule-associated tau protein species from bovine brain and their mode II phosphorylation by Ca2+/phospholipid-dependent protein kinase C. , 1987, The Journal of biological chemistry.

[88]  O. Petersen,et al.  Synergism of inositol trisphosphate and tetrakisphosphate in activating Ca2+-dependent K+ channels , 1987, Nature.

[89]  A. Matus,et al.  Age-related increase in a cathepsin D like protease that degrades brain microtubule-associated proteins. , 1987, Biochemistry.

[90]  D. Kaplan,et al.  Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation. , 1987, The Biochemical journal.

[91]  S. Courtneidge,et al.  An 81 kd protein complexed with middle T antigen and pp60c-src : A possible phosphatidylinositol kinase , 1987, Cell.

[92]  G. Gibson,et al.  Calcium and the aging nervous system , 1987, Neurobiology of Aging.

[93]  J. Harris,et al.  Calcium and neuronal cytoskeletal proteins: Alterations with aging , 1987, Neurobiology of Aging.

[94]  G. Barritt Intracellular free calcium and inositol polyphosphate action as potential targets in the ageing process , 1987, Neurobiology of Aging.

[95]  T. Akiyama,et al.  Protein kinase C phosphorylates tau and induces its functional alterations , 1987, FEBS letters.

[96]  M. G. Low,et al.  Biochemistry of the glycosyl-phosphatidylinositol membrane protein anchors. , 1987, The Biochemical journal.

[97]  I. Litosch Guanine nucleotide and NaF stimulation of phospholipase C activity in rat cerebral-cortical membranes. Studies on substrate specificity. , 1987, The Biochemical journal.

[98]  J. Hawthorne,et al.  Reduced Phosphoinositide Concentrations in Anterior Temporal Cortex of Alzheimer‐Diseased Brains , 1987, Journal of neurochemistry.

[99]  P. Coleman,et al.  Dendritic extent in human dentate gyrus granule cells in normal aging and senile dementia , 1987, Brain Research.

[100]  M. Berridge,et al.  Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+. , 1986, The Biochemical journal.

[101]  G. Zubenko Hippocampal membrane alteration in Alzheimer's disease , 1986, Brain Research.

[102]  J. Parente,et al.  Use of fluoride ion as a probe for the guanine nucleotide‐binding protein involved in the phosphoinositide‐dependent neutrophil transduction pathway , 1986, FEBS letters.

[103]  A. A. Abdel-Latif Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers. , 1986, Pharmacological reviews.

[104]  P. Cuatrecasas,et al.  Insulin-stimulated hydrolysis of a novel glycolipid generates modulators of cAMP phosphodiesterase. , 1986, Science.

[105]  Y. Nishizuka Studies and perspectives of protein kinase C. , 1986, Science.

[106]  A. Kowluru,et al.  Secretagogue-responsive and -unresponsive pools of phosphatidylinositol in pancreatic islets. , 1986, Archives of biochemistry and biophysics.

[107]  J. Smith,et al.  Temperature and nucleotide dependence of calcium release by myo-inositol 1,4,5-trisphosphate in cultured vascular smooth muscle cells. , 1985, The Journal of biological chemistry.

[108]  J. Putney,et al.  Inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate formation in Ca2+-mobilizing-hormone-activated cells. , 1985, The Biochemical journal.

[109]  E. Anggard,et al.  Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands. , 1985, The Biochemical journal.

[110]  L. Cantley,et al.  Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation , 1985, Nature.

[111]  E. Neufeld,et al.  Phosphoinositide interconversion in thrombin-stimulated human platelets. , 1985, The Journal of biological chemistry.

[112]  M. Berridge Inositol trisphosphate and diacylglycerol as second messengers. , 1984, The Biochemical journal.

[113]  Y. Nishizuka The role of protein kinase C in cell surface signal transduction and tumour promotion , 1984, Nature.

[114]  Jonathan A. Cooper,et al.  C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity. , 1984, The Journal of biological chemistry.

[115]  M. Monaco,et al.  Characterization of the hormone-sensitive phosphatidylinositol pool in WRK-1 cells. , 1983, The Journal of biological chemistry.

[116]  M. J. Berridge,et al.  Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate , 1983, Nature.

[117]  J. Hawthorne,et al.  Free and total lipid myo-inositol concentrations decrease with age in human brain. , 1983, Biochimica et biophysica acta.

[118]  M. Berridge,et al.  Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. , 1983, The Biochemical journal.

[119]  G. Calderini,et al.  Biochemical changes of rat brain membranes with aging , 1983, Neurochemical Research.

[120]  E. Lapetina,et al.  Rapid decrease of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets. , 1982, The Journal of biological chemistry.

[121]  F. Crews,et al.  Age dependent changes in the methylation of rat brain phospholipids , 1981, Brain Research.

[122]  P. Cuatrecasas,et al.  Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets. , 1981, The Journal of biological chemistry.

[123]  D. Hegner Age-dependence of molecular and functional changes in biological membrane properties , 1980, Mechanisms of Ageing and Development.

[124]  J. Putney,et al.  Is phosphatidic acid a calcium ionophore under neurohumoral control? , 1980, Nature.

[125]  M. Berridge,et al.  Relationship between phosphatidylinositol synthesis and recovery of 5-hydroxytryptamine-responsive Ca2+ flux in blowfly salivary glands. , 1979, The Biochemical journal.

[126]  A. Globerson,et al.  Viscosity of lymphocyte plasma membrane in aging mice and its possible relation to serum cholesterol , 1979, Mechanisms of Ageing and Development.

[127]  A. Globerson,et al.  Perturbation of lymphocyte response to concanavalin A by exogenous cholesterol and lecithin , 1978 .

[128]  J. Eichberg,et al.  Diphosphoinositide and triphosphoinositide in animal tissues. Extraction, estimation and changes post mortem. , 1965, The Biochemical journal.

[129]  L. Hokin,et al.  Enzyme secretion and the incorporation of P32 into phospholipides of pancreas slices. , 1953, The Journal of biological chemistry.

[130]  B. Corain Alzheimer's disease : advances in clinical and basic research , 1993 .

[131]  K. Iqbal Alzheimer's disease : basic mechanisms, diagnosis and therapeutic strategies , 1991 .

[132]  C. Salzman Aging Brain and Dementia: New Trends in Diagnosis and Therapy , 1991 .

[133]  V. Lee,et al.  Characterization and differential distribution of the three major human protein kinase C isozymes (PKC alpha, PKC beta, and PKC gamma) of the central nervous system in normal and Alzheimer's disease brains. , 1991, Laboratory investigation; a journal of technical methods and pathology.

[134]  M. Trabucchi,et al.  The aging brain: protein phosphorylation as a target of changes in neuronal function. , 1991, Life sciences.

[135]  C. Downes,et al.  Phosphoinositide 3-kinase: a new effector in signal transduction? , 1991, Cellular signalling.

[136]  Stanley I. Rapoport,et al.  Imaging, Cerebral Topography and Alzheimer’s Disease , 1990, Research and Perspectives in Alzheimer’s Disease.

[137]  B. S. Alam,et al.  Effect of ageing on adenylate cyclase activity and G-proteins in rat submandibular salivary glands. , 1990, Archives of oral biology.

[138]  M. Berridge,et al.  Inositol trisphosphate and diacylglycerol: two interacting second messengers. , 1987, Annual review of biochemistry.

[139]  L. Hokin Receptors and phosphoinositide-generated second messengers. , 1985, Annual review of biochemistry.

[140]  M. Shinitzky,et al.  The modulation of protein phosphorylation and receptor binding in synaptic membranes by changes in lipid fluidity: implications for ageing. , 1982, Progress in brain research.