Management of aggressive vertebral hemangioma with cord compression

Objective: Aggressive vertebral hemangiomas (VHs) causing spinal compression are rare and there is controversy regarding treatment. This study aims to evaluate clinical results of patients with aggressive VHs after laminectomy, radiotherapy and vertebroplasty with spinal fi xation and to discuss treatment options of tumors. Methods: We performed a retrospective study in 8 patients with aggressive VHs treated with laminectomy, radiotherapy and vertebroplasty with spinal fi xation. In all the patients, tumor was either in thoracic or lumbar spine resulting in myelopathy with extraosseous extension. Tumors were assessed using magnetic resonance imaging (MRI) and the clinical results were evaluated. Results: All of the tumors showed low-intensity or low to isointensity signal on T1-weighted MRI. Laminectomy with or without irradiation was performed in 5 patients. Two patients underwent vertebroplasty with spinal fi xation and conventional radiotherapy was performed in 1 patient. There was no preoperative complication. The myelopathy and patients’ symptoms improved after the surgery. None of the patients had a recurrence at a mean follow-up period of 48 months. Conclusions: A combination of laminectomy, radiotherapy and vertebroplasty with or without spinal fi xation is suggested for the treatment of aggressive VHs with extraosseous extension caused spinal cord compression in all the patients. The clinical results proved satisfactorily in the long-term follow-up.

[1]  A. Kiani,et al.  The Efficacy of Percutaneous Vertebroplasty in Pain Relief in Patients with Pathological Vertebral Fractures due to Metastatic Spinal Tumors , 2012, Iranian Red Crescent medical journal.

[2]  A. Rahmanian,et al.  Posterolateral versus posterior interbody fusion in isthmic spondylolisthesis. , 2012, Journal of neurotrauma.

[3]  M. Farrokhi,et al.  Efficacy of Prophylactic Low Dose of Tranexamic Acid in Spinal Fixation Surgery: A Randomized Clinical Trial , 2011, Journal of neurosurgical anesthesiology.

[4]  E. Alibai,et al.  Randomized controlled trial of percutaneous vertebroplasty versus optimal medical management for the relief of pain and disability in acute osteoporotic vertebral compression fractures. , 2011, Journal of neurosurgery. Spine.

[5]  J. Urrutia,et al.  Clinical and imaging findings in patients with aggressive spinal hemangioma requiring surgical treatment , 2011, Journal of Clinical Neuroscience.

[6]  M. Vasei,et al.  Effect of Honey on Peridural Fibrosis Formation after Laminectomy in Rats: A Novel Experimental Study , 2011, Evidence-based complementary and alternative medicine : eCAM.

[7]  C. Sarkar,et al.  Treatment of Vertebral Hemangiomas With Absolute Alcohol (Ethanol) Embolization, Cord Decompression, and Single Level Instrumentation: A Pilot Study , 2011, Neurosurgery.

[8]  Seung-Won Park,et al.  Capillary hemangioma of the thoracic spinal cord. , 2010, Journal of Korean Neurosurgical Society.

[9]  S. Torabinezhad,et al.  Pilot Study of a New Acrylic Cage in a Dog Cervical Spine Fusion Model , 2010, Journal of spinal disorders & techniques.

[10]  A. Razmkon,et al.  Inclusion of the fracture level in short segment fixation of thoracolumbar fractures , 2010, European Spine Journal.

[11]  K. Tomita,et al.  Surgical management of aggressive vertebral hemangiomas causing spinal cord compression: long-term clinical follow-up of five cases , 2010, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[12]  H. Eich,et al.  Radiotherapy for symptomatic vertebral hemangiomas: results of a multicenter study and literature review. , 2010, International journal of radiation oncology, biology, physics.

[13]  Phalguni Gupta,et al.  Symptomatic vertebral hemangioma: treatment with radiotherapy. , 2010, Journal of cancer research and therapeutics.

[14]  B. Bruel,et al.  Management of painful vertebral hemangiomas with kyphoplasty: a report of two cases and a literature review. , 2009, Pain physician.

[15]  D. Evangelopoulos,et al.  Cement leakage in a symptomatic vertebral hemangioma: a case report and review of the literature , 2009, Cases journal.

[16]  M. Muto,et al.  Vertebroplasty as treatment of aggressive and symptomatic vertebral hemangiomas: up to 4 years of follow-up , 2009, Neuroradiology.

[17]  I. Maleki,et al.  Incidence of vertebral hemangioma on spinal magnetic resonance imaging in Northern Iran. , 2009, Pakistan journal of biological sciences : PJBS.

[18]  L. Rosales-Olivares,et al.  [Vertebral hemangioma of the posterior arch with subsequent extraosseous extension and neurological symptoms. Case report and literature review]. , 2009, Cirugia y cirujanos.

[19]  K. Tomita,et al.  Total en bloc spondylectomy for spinal tumors: surgical techniques and related basic background. , 2009, The Orthopedic clinics of North America.

[20]  P. Weinstein,et al.  Comprehensive management of symptomatic and aggressive vertebral hemangiomas. , 2008, Neurosurgery clinics of North America.

[21]  P. Weinstein,et al.  Current Treatment Strategies and Outcomes in the Management of Symptomatic Vertebral Hemangiomas , 2006, Neurosurgery.

[22]  K. Tomita,et al.  Total en bloc spondylectomy for spinal tumors: improvement of the technique and its associated basic background , 2006, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[23]  B. Wang,et al.  [Surgical treatment of thoracic vertebral angioma with extraosseous extension causing spinal cord compression]. , 2005, Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.

[24]  M. Chandy,et al.  Management of symptomatic vertebral hemangiomas: review of 13 patients. , 2002, Neurology India.

[25]  R. Pozderac,et al.  Vertebral hemangioma presenting as a cold defect on bone scintigraphy. , 2001, Clinical nuclear medicine.

[26]  T. Bas,et al.  Efficacy and Safety of Ethanol Injections in 18 Cases of Vertebral Hemangioma: A Mean Follow-Up of 2 Years , 2001, Spine.

[27]  J. Doppman,et al.  Symptomatic vertebral hemangiomas: treatment by means of direct intralesional injection of ethanol. , 2000, Radiology.

[28]  R. Schwarz,et al.  Ergebnisse der Strahlentherapie von Wirbelkörperangiomen , 1999, Strahlentherapie und Onkologie.

[29]  A. Krüll,et al.  [Results of radiotherapy for vertebral hemangioma]. , 1999, Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al].

[30]  E. I. Slin'ko,et al.  Vertebral hemangiomas: diagnosis, management, natural history and clinicopathological correlates in 86 patients. , 1998, Surgical neurology.

[31]  M. W. Fox,et al.  The natural history and management of symptomatic and asymptomatic vertebral hemangiomas. , 1993, Journal of neurosurgery.

[32]  J. Grotenhuis,et al.  Symptomatic vertebral hemangiomas. , 1991, Journal of neurosurgical sciences.

[33]  H. Deramond,et al.  [Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty]. , 1987, Neuro-Chirurgie.

[34]  J. Laredo,et al.  Vertebral hemangiomas: radiologic evaluation. , 1986, Radiology.

[35]  R. Bumsted,et al.  Case Report and Literature Review , 1980 .

[36]  V. L. McAllister,et al.  Symptomatic vertebral haemangiomas. , 1975, Brain : a journal of neurology.

[37]  J. Pfeiffer [Diagnosis and therapy of vertebral hemangioma]. , 1972, Das Deutsche Gesundheitswesen.

[38]  K. Unni,et al.  Hemangioma, hemangiopericytoma, and hemangioendothelioma (angiosarcoma) of bone , 1971, Cancer.

[39]  A. Bergstrand,et al.  Vertebral haemangiomas copressing the spinal cord. , 1963, Acta neurologica Scandinavica.