Ultrasound-assisted insulin delivery and noninvasive glucose sensing.

Peptides and proteins are emerging as an increasingly important class of drugs as they become more readily available through improvement in recombinant DNA technology and chemical synthesis techniques. The application of peptides and proteins as clinically useful drugs is, however, seriously hampered owing to the substantial delivery problems requiring frequent injections. Considerable effort has been directed therefore to developing painless and convenient methods for delivery of peptides and proteins. In diabetes, in addition to the need of insulin injections there is a need to develop painless and convenient methods to measure blood glucose. This review describes approaches based on the application of ultrasound for noninvasive and painless transdermal glucose sensing and delivery of insulin.

[1]  R. Langer,et al.  Molecular Weight Changes in Polymer Erosion , 1992, Pharmaceutical Research.

[2]  J. Hadgraft,et al.  Influence of Ultrasound on the Percutaneous Absorption of Nicotinate Esters , 1991, Pharmaceutical Research.

[3]  J Kost,et al.  Effect of ultrasound on transdermal drug delivery to rats and guinea pigs. , 1989, The Journal of clinical investigation.

[4]  B. Ratner,et al.  Self-assembled molecular structures as ultrasonically-responsive barrier membranes for pulsatile drug delivery. , 2001, Journal of biomedical materials research.

[5]  K. Tachibana,et al.  Transdermal delivery of insulin by ultrasonic vibration , 1991, The Journal of pharmacy and pharmacology.

[6]  Samir Mitragotri,et al.  Transdermal monitoring of glucose and other analytes using ultrasound , 2000, Nature Medicine.

[7]  B. Zinman,et al.  Alternative routes of insulin delivery , 2003, Diabetic medicine : a journal of the British Diabetic Association.

[8]  S. Mitragotri,et al.  Combined Effect of Low-Frequency Ultrasound and Iontophoresis: Applications for Transdermal Heparin Delivery , 2000, Pharmaceutical Research.

[9]  J. McElnay,et al.  Use of ultrasound to enhance percutaneous absorption of benzydamine. , 1989, Physical therapy.

[10]  S. Mitragotri,et al.  Synergistic effect of low-frequency ultrasound and sodium lauryl sulfate on transdermal transport. , 2000, Journal of pharmaceutical sciences.

[11]  S. Mitragotri,et al.  A mechanistic study of ultrasonically-enhanced transdermal drug delivery. , 1995, Journal of pharmaceutical sciences.

[12]  S. Mitragotri,et al.  Synergistic effects of chemical enhancers and therapeutic ultrasound on transdermal drug delivery. , 1996, Journal of pharmaceutical sciences.

[13]  Kenneth S. Suslick,et al.  Ultrasound: Its Chemical, Physical, and Biological Effects , 1988 .

[14]  J Kost,et al.  Low‐Frequency Sonophoresis: A Noninvasive Method of Drug Delivery and Diagnostics , 2000, Biotechnology progress.

[15]  J. Kost,et al.  Ultrasonically enhanced transdermal drug delivery. Experimental approaches to elucidate the mechanism. , 1993, Journal of biomaterials science. Polymer edition.

[16]  S. Mitragotri,et al.  Ultrasound-mediated transdermal protein delivery , 1995, Science.

[17]  S. Mitragotri,et al.  Theoretical description of transdermal transport of hydrophilic permeants: application to low-frequency sonophoresis. , 2001, Journal of pharmaceutical sciences.

[18]  R. Newnham,et al.  Noninvasive ultrasonic transdermal insulin delivery in rabbits using the light-weight cymbal array. , 2003, Diabetes technology & therapeutics.

[19]  J. Kost,et al.  Ultrasound-enhanced polymer degradation and release of incorporated substances. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[20]  J. McElnay,et al.  Phonophoresis of lignocaine and prilocaine from Emla cream , 1988 .

[21]  K. Tachibana.  Transdermal Delivery of Insulin to Alloxan-Diabetic Rabbits by Ultrasound Exposure , 1992, Pharmaceutical Research.

[22]  External control of drug release: controlled release of insulin from a hydrophilic polymer implant by ultrasound irradiation in diabetic rats , 1988, The Journal of pharmacy and pharmacology.

[23]  Samir Mitragotri,et al.  Synergistic Effect of Electric Field and Ultrasound on Transdermal Transport , 1996, Pharmaceutical Research.

[24]  R. Scheuplein,et al.  Permeability of the Skin , 1971 .

[25]  R. Guy,et al.  Sonophoresis. II. Examination of the Mechanism(s) of Ultrasound-Enhanced Transdermal Drug Delivery , 1992, Pharmaceutical Research.

[26]  J. Kost,et al.  Ultrasonically controlled polymeric drug delivery , 1988 .

[27]  J. Simonin.  On the mechanisms of in vitro and in vivo phonophoresis , 1995 .

[28]  R. Guy,et al.  Sonophoresis. I. The Use of High-Frequency Ultrasound to Enhance Transdermal Drug Delivery , 1992, Pharmaceutical Research.