A photoreactive small-molecule probe for 2-oxoglutarate oxygenases.

[1]  A. Jadhav,et al.  Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors , 2010, PloS one.

[2]  N. Moroz,et al.  Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation. , 2010, Chemistry & biology.

[3]  C. Schofield,et al.  Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents. , 2010, The Biochemical journal.

[4]  Anna K. Schrey,et al.  Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). , 2010, Journal of proteome research.

[5]  C. Schofield,et al.  Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions. , 2010, Journal of medicinal chemistry.

[6]  Zhongzhou Chen,et al.  Structural insights into a novel histone demethylase PHF8 , 2010, Cell Research.

[7]  Thomas G. Smith,et al.  Therapeutic manipulation of the HIF hydroxylases. , 2010, Antioxidants & redox signaling.

[8]  Christopher J. Schofield,et al.  Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches† , 2010, Journal of medicinal chemistry.

[9]  Wolfgang Sippl,et al.  The Emerging Therapeutic Potential of Histone Methyltransferase and Demethylase Inhibitors , 2009, ChemMedChem.

[10]  Heather L. Plasterer,et al.  Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing. , 2009, Chemistry & biology.

[11]  R. Sormunen,et al.  Reduction of Lysyl Hydroxylase 3 Causes Deleterious Changes in the Deposition and Organization of Extracellular Matrix* , 2009, The Journal of Biological Chemistry.

[12]  C. Domene,et al.  Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases. , 2009, Structure.

[13]  C. Schofield,et al.  Oxygenase catalyzed 5-methylcytosine hydroxylation. , 2009, Chemistry & biology.

[14]  F. Sobott,et al.  Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure. , 2009, Journal of medicinal chemistry.

[15]  P. Ratcliffe,et al.  Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. , 2008, The Biochemical journal.

[16]  U. Oppermann,et al.  Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. , 2008, Journal of medicinal chemistry.

[17]  W. Kaelin,et al.  Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. , 2008, Molecular cell.

[18]  Christopher J Schofield,et al.  Expanding chemical biology of 2-oxoglutarate oxygenases. , 2008, Nature chemical biology.

[19]  B. Cravatt,et al.  Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes. , 2008, Journal of the American Chemical Society.

[20]  Yi Zhang,et al.  Regulation of histone methylation by demethylimination and demethylation , 2007, Nature Reviews Molecular Cell Biology.

[21]  M. Bogyo,et al.  Tagging and detection strategies for activity-based proteomics. , 2007, Current opinion in chemical biology.

[22]  E. Liepinsh,et al.  Mildronate, an Inhibitor of Carnitine Biosynthesis, Induces an Increase in Gamma-Butyrobetaine Contents and Cardioprotection in Isolated Rat Heart Infarction , 2006, Journal of cardiovascular pharmacology.

[23]  Carol Winter,et al.  Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors. , 2006, Bioorganic & medicinal chemistry letters.

[24]  B. Cravatt,et al.  Mechanism-based profiling of enzyme families. , 2006, Chemical reviews.

[25]  Sherry L. Niessen,et al.  Proteomic profiling of metalloprotease activities with cocktails of active-site probes , 2006, Nature chemical biology.

[26]  H. Erdjument-Bromage,et al.  Histone demethylation by a family of JmjC domain-containing proteins , 2006, Nature.

[27]  N. Oldham,et al.  Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate. , 2005, Molecular bioSystems.

[28]  C. Schwartz,et al.  Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate , 2005, Journal of Medical Genetics.

[29]  L. del Peso,et al.  Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene. , 2005, The Biochemical journal.

[30]  C. Schofield,et al.  Selective inhibition of factor inhibiting hypoxia-inducible factor. , 2005, Journal of the American Chemical Society.

[31]  J. Gécz,et al.  Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation. , 2005, American journal of human genetics.

[32]  A. Harris,et al.  Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor* , 2004, Journal of Biological Chemistry.

[33]  Robert P. Hausinger,et al.  Fe(II)/α-Ketoglutarate-Dependent Hydroxylases and Related Enzymes , 2004 .

[34]  M. MacCoss,et al.  Shotgun proteomics: tools for the analysis of complex biological systems. , 2002, Current opinion in molecular therapeutics.

[35]  Michael I. Wilson,et al.  C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation , 2001, Cell.

[36]  H. Ploegh,et al.  Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits. , 2001, Chemistry & biology.

[37]  S. Fleming.  Chemical reagents in photoaffinity labeling , 1995 .