Designing and developing automatic techniques for magnetic resonance images (MR) for data analysis is very challenging. One popular and public available method, FAST (FMRIB Automatic Segmentation Tool) has been widely used for automatic brain tissue segmentation for this purpose. This paper investigates limitations of this software algorithm on implementation and further develops a new approach to automatic MR brain tissue classification. The proposed new technique first implements an unsupervised training sample generation process (UTSGP) which includes a Pixel Purity Index (PPI) to generate an initial set of training samples that are further refined by a Support Vector Machine. The resulting training samples are then as a set of training samples for an Iterative Fisher’s Linear Discriminant Analysis (IFLDA) which implements FLDA iteratively to improve classification. In order to conduct a fair comparison synthetic images are used for performance evaluation. Experimental results show that our proposed technique is superior in practical implementation to this software algorithm in several aspects of generalization ability, flexibility of choosing number of classes to be classified, avoidance of inconsistent results caused by different initial conditions.
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