STUDIES ON SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF REDUCED SCHIFF BASES OF PHENYLALANINE DERIVATIVES

Non steroidal anti inflammatory drugs (NSAID’S) are widely used for the treatment of pain and inflammation since from 28 years, but all the NSAID’S are suffering from the deadlier GI toxicities due to the presence of free carboxylic group. In the current research work, different substituted N-benzylphenylalanine (Ia-i) were synthesized by condensation of (DL)Phenylalanine with various substituted aromatic aldehydes followed by insitu reduction with sodium borohydride. Thus obtained different substituted N-benzylphenylalanine (Ia-i) on esterification using thionyl chloride and methanol gave phenylalanine derivatives (IIa-i). The purity of these synthesized compounds was confirmed by melting point and TLC. The structure of these synthesized compounds was characterized by spectral studies which include IR, 1 H-NMR and elemental analysis. All these newly synthesised compounds (IIa-i) were screened for acute anti-inflammatory activity by carrageenan induced rat paw edema method. Results of antiinflammatory activity revealed that compounds II c and II d showed comparable activity to standard diclofenac sodium.

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