Cabergoline may act as a radioprotective agent in Cushing's disease

Conventional fractionated radiotherapy (CRT) achieves control of pathological hypercortisolism in 75%‐80% of patients with persistent or recurrent Cushing's disease (CD), over a mean period of 18‐24 months. Medical therapy is recommended as bridge therapy while awaiting RT effect.

[1]  John Y. K. Lee,et al.  Technique of Whole-Sellar Stereotactic Radiosurgery for Cushing Disease: Results from a Multicenter, International Cohort Study. , 2018, World neurosurgery.

[2]  Fares Alahdab,et al.  PREDICTORS OF BIOCHEMICAL REMISSION AND RECURRENCE AFTER SURGICAL AND RADIATION TREATMENTS OF CUSHING DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS. , 2016, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[3]  M. A. O. Ignacio,et al.  How to cite this article , 2016 .

[4]  A. Tabarin,et al.  Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline. , 2015, The Journal of clinical endocrinology and metabolism.

[5]  M. Bronstein,et al.  Ketoconazole Treatment Decreases the Viability of Immortalized Pituitary Cell Lines Associated with an Increased Expression of Apoptosis‐Related Genes and Cell Cycle Inhibitors , 2015, Journal of neuroendocrinology.

[6]  A. Colao,et al.  The Treatment of Cushing's Disease. , 2015, Endocrine reviews.

[7]  P. Chanson,et al.  Therapy of endocrine disease: outcomes in patients with Cushing's disease undergoing transsphenoidal surgery: systematic review assessing criteria used to define remission and recurrence. , 2015, European journal of endocrinology.

[8]  A. Gutierrez-Hartmann,et al.  Signaling pathways regulating pituitary lactotrope homeostasis and tumorigenesis. , 2015, Advances in experimental medicine and biology.

[9]  T. Gupta,et al.  Encouraging efficacy of modern conformal fractionated radiotherapy in patients with uncured Cushing’s disease , 2014, Pituitary.

[10]  Paul J. Schmitt,et al.  Results of gamma knife surgery for Cushing's disease. , 2013, Journal of neurosurgery.

[11]  N. Shah,et al.  Efficacy of cabergoline in uncured (persistent or recurrent) Cushing disease after pituitary surgical treatment with or without radiotherapy. , 2010, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[12]  M. Bondanelli,et al.  Control of pituitary adenoma cell proliferation by somatostatin analogs, dopamine agonists and novel chimeric compounds. , 2007, European journal of endocrinology.

[13]  V. Esposito,et al.  Long-term follow-up results of postoperative radiation therapy for Cushing’s disease , 2007, Journal of Neuro-Oncology.

[14]  J. Régis,et al.  Gamma knife radiosurgery is a successful adjunctive treatment in Cushing's disease. , 2007, European journal of endocrinology.

[15]  A. Landolt,et al.  Gamma knife radiosurgery for prolactinomas. , 2000, Journal of neurosurgery.

[16]  S. Scheib,et al.  Octreotide may act as a radioprotective agent in acromegaly. , 2000, The Journal of clinical endocrinology and metabolism.

[17]  R. Magallón,et al.  The long-term outcome of pituitary irradiation after unsuccessful transsphenoidal surgery in Cushing's disease. , 1997, The New England journal of medicine.

[18]  N. Yamakita,et al.  Long term follow-up of Cushing's disease treated with reserpine and pituitary irradiation. , 1992, The Journal of clinical endocrinology and metabolism.

[19]  M. Littley,et al.  LONG‐TERM FOLLOW‐UP OF LOW‐DOSE EXTERNAL PITUITARY IRRADIATION FOR CUSHING'S DISEASE , 1990, Clinical endocrinology.