Analysing Hypersensitivity to Chemotherapy in a Cellular Automata Model of the Immune System

12.4 Model Validation and Simulation Results 12.4.1 Healthy Subjects: Primary and Secondary Immune Response to a Generic Antigen 12.4.2 Allergic Subjects: Sensitisation and Hypersensitivity to a Generic Allergenic Drug 12.4.3 Effects of IFNand IL-4 12.4.4 Hypersensitivity Dependence on Drug Dose 12.4.5 Dependence of Hypersensitivity on Dosing Interval 12.4.6 Fractionating the Drug Dose into Multiple Dosings

[1]  Z. Agur,et al.  A theoretical analysis of interval drug dosing for cell-cycle-phase-specific drugs. , 1992, Mathematical biosciences.

[2]  Franco Celada,et al.  Affinity maturation and hypermutation in a simulation of the humoral immune response , 1996, European journal of immunology.

[3]  M. Norcross,et al.  Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes. , 1995, Blood.

[4]  L. Segel,et al.  Th1 or Th2: How an appropriate T helper response can be made , 2001, Bulletin of mathematical biology.

[5]  Yuval Ginosar,et al.  The universal properties of stem cells as pinpointed by a simple discrete model , 2002, Journal of mathematical biology.

[6]  P Ubezio,et al.  Increasing 1-beta-D-arabinofuranosylcytosine efficacy by scheduled dosing intervals based on direct measurements of bone marrow cell kinetics. , 1994, Cancer research.

[7]  M. Jenmalm,et al.  Allergen‐induced Th1 and Th2 cytokine secretion in relation to specific allergen sensitization and atopic symptoms in children , 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[8]  G. Weisbuch,et al.  Immunology for physicists , 1997 .

[9]  Z. Agur Resilience and variability in pathogens and hosts. , 1987, IMA journal of mathematics applied in medicine and biology.

[10]  S T Holgate,et al.  Allergic disorders , 2000, BMJ : British Medical Journal.

[11]  Denise Kirschner,et al.  A model for treatment strategy in the chemotherapy of AIDS , 1996 .

[12]  C. Schmidt,et al.  Anaphylaktische Reaktion unter Cyclophosphamid-Infusion , 1983 .

[13]  Zvia Agur,et al.  Reduction of cytotoxicity to normal tissues by new regimens of cell-cycle phase-specific drugs , 1988 .

[14]  R. Ahmed,et al.  Humoral immunity due to long-lived plasma cells. , 1998, Immunity.

[15]  G. Marchuk,et al.  Mathematical model of antiviral immune response. I. Data analysis, generalized picture construction and parameters evaluation for hepatitis B. , 1991, Journal of theoretical biology.

[16]  G. I. Bell,et al.  Mathematical Model of Clonal Selection and Antibody Production , 1970, Nature.

[17]  R Puzone,et al.  A systematic approach to vaccine complexity using an automaton model of the cellular and humoral immune system. I. Viral characteristics and polarized responses. , 2000, Vaccine.

[18]  Z. Szépfalusi,et al.  IgE-mediated allergic reaction to hyaluronidase in paediatric oncological patients , 1997, European Journal of Pediatrics.

[19]  Andrew Ilachinski,et al.  Cellular Automata: A Discrete Universe , 2001 .

[20]  I. Meilijson,et al.  Maturation of the humoral immune response as an optimization problem , 1991, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[21]  P E Seiden,et al.  A computer model of cellular interactions in the immune system. , 1992, Immunology today.

[22]  G. Oster,et al.  Theoretical studies of clonal selection: minimal antibody repertoire size and reliability of self-non-self discrimination. , 1979, Journal of theoretical biology.

[23]  K C Barnes,et al.  The genetics and complexity of allergy and asthma. , 1998, Immunology today.

[24]  F. Finkelman,et al.  Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice , 1995, The Journal of experimental medicine.

[25]  P E Seiden,et al.  A model for simulating cognate recognition and response in the immune system. , 1992, Journal of theoretical biology.

[26]  R. Ahmed,et al.  Models of immune memory: on the role of cross-reactive stimulation, competition, and homeostasis in maintaining immune memory. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[27]  J. Banchereau,et al.  IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants. , 1988, Journal of immunology.

[28]  Paolo Ubezio,et al.  AZT EFFECT ON THE BONE MARROW — A NEW PERSPECTIVE ON THE CONCORDE TRIAL , 1995 .

[29]  Alan S. Perelson,et al.  Mathematical Analysis of HIV-1 Dynamics in Vivo , 1999, SIAM Rev..

[30]  M. Wills-Karp,et al.  Interleukin‐12 as a target for modulation of the inflammatory response in asthma , 1998, Allergy.

[31]  A. Zhabotinsky,et al.  Mathematical model of cancer chemotherapy. periodic schedules of phase-specific cytotoxic-agent administration increasing the selectivty of therapy , 1985 .

[32]  C. Schmidt,et al.  [Anaphylactic reaction in cyclophosphamide infusion]. , 1983, Onkologie.

[33]  A B Kay,et al.  Allergy and allergic diseases. Second of two parts. , 2001, The New England journal of medicine.

[34]  Mimicking the Strategy of the Immune System: Insight Gained from Mathematics , 1992 .

[35]  A. McLean,et al.  Modelling T cell memory. , 1994, Journal of theoretical biology.

[36]  Z. Agur,et al.  Effect of the dosing interval on myelotoxicity and survival in mice treated by cytarabine. , 1992, European journal of cancer.

[37]  R. Ozols,et al.  Successful parenteral desensitization to paclitaxel. , 1996, The Journal of allergy and clinical immunology.

[38]  K. Rajewsky,et al.  Generation and analysis of interleukin-4 deficient mice. , 1991, Science.

[39]  F Castiglione,et al.  Design and implementation of an immune system simulator , 2001, Comput. Biol. Medicine.

[40]  R. Thisted,et al.  Tryptase Levels Are Not Increased during Vancomycin-induced Anaphylactoid Reactions , 1998, Anesthesiology.

[41]  Denise E. Kirschner,et al.  Using Mathematics to Understand HIV Immune Dynamics , 1997 .

[42]  F. Levi-Schaffer,et al.  Human eosinophils induce histamine release from antigen-activated rat peritoneal mast cells: a possible role for mast cells in late-phase allergic reactions. , 2001, The Journal of allergy and clinical immunology.

[43]  G. F. Webb,et al.  Resonance phenomena in cell population chemotherapy models , 1990 .

[44]  G. I. Bell Mathematical model of clonal selection and antibody production. II. , 1971, Journal of theoretical biology.

[45]  W. Kwong,et al.  The Annals of Pharmacotherapy , 1996 .

[46]  L. Segel,et al.  On the role of feedback in promoting conflicting goals of the adaptive immune system. , 1999, Journal of immunology.

[47]  M A Nowak,et al.  Mathematical biology of HIV infections: antigenic variation and diversity threshold. , 1991, Mathematical biosciences.

[48]  Z Agur,et al.  Zidovudine toxicity to murine bone marrow may be affected by the exact frequency of drug administration. , 1991, Experimental hematology.

[49]  D. Umetsu,et al.  Interleukin 4 production by CD4+ T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type , 1995, The Journal of experimental medicine.

[50]  T. R. Mosrnann TH1 AND TH2 CELLS: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties , 2005 .

[51]  G. Marchuk,et al.  Mathematical model of antiviral immune response. II. Parameters identification for acute viral hepatitis B. , 1991, Journal of theoretical biology.

[52]  R. Coffman,et al.  TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. , 1989, Annual review of immunology.

[53]  H. Sakura,et al.  Occurrence of an anti-peplomycin IgE antibody cross-reacting with bleomycin in a patient with cervical uterine cancer , 2004, Cancer Chemotherapy and Pharmacology.

[54]  A Magnan,et al.  Venom immunotherapy induces monocyte activation , 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[55]  P E Seiden,et al.  Modelling thymic functions in a cellular automaton. , 1995, International immunology.

[56]  S. Holgate,et al.  The role of IgE in allergen‐induced inflammation and the potential for intervention with a humanized monoclonal anti‐IgE antibody , 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.