Construction of DNA nanotubes with controllable diameters and patterns using hierarchical DNA sub-tiles.

The design of DNA nanotubes is a promising and hot research branch in structural DNA nanotechnology, which is rapidly developing as a versatile method for achieving subtle nanometer scale materials and molecular diagnostic/curative devices. Multifarious methods have been proposed to achieve varied DNA nanotubes, such as using square tiles and single-stranded tiles, but it is still a challenge to develop a bottom-up assembly way to build DNA nanotubes with different diameters and patterns using certain universal DNA nanostructures. This work addresses the challenge by assembling three types of spatial DNA nanotubes with different diameters and patterns from the so-called "basic bricks", i.e., hierarchical DNA sub-tiles. A high processing rate and throughput synthesis of DNA nanotubes are observed and analyzed by atomic force microscopy. Experimental observations and data analysis suggests the stability and controllability of DNA nanotubes assembled by hierarchical DNA sub-tiles.

[1]  Chad A. Mirkin,et al.  Nanoparticle Superlattice Engineering with DNA , 2011, Science.

[2]  N. Seeman,et al.  A robust DNA mechanical device controlled by hybridization topology , 2002, Nature.

[3]  J. Reif,et al.  Electronic nanostructures templated on self-assembled DNA scaffolds , 2004 .

[4]  Chengde Mao,et al.  Highly connected two-dimensional crystals of DNA six-point-stars. , 2006, Journal of the American Chemical Society.

[5]  J. Storhoff,et al.  A DNA-based method for rationally assembling nanoparticles into macroscopic materials , 1996, Nature.

[6]  Erik Winfree,et al.  Self-assembly of carbon nanotubes into two-dimensional geometries using DNA origami templates. , 2010, Nature nanotechnology.

[7]  Nadrian C Seeman,et al.  Structural DNA nanotechnology: growing along with Nano Letters. , 2010, Nano letters.

[8]  Linqiang Pan,et al.  A Novel Bio-Sensor Based on DNA Strand Displacement , 2014, PloS one.

[9]  Linqiang Pan,et al.  Programmable DNA tile self-assembly using a hierarchical sub-tile strategy , 2014, Nanotechnology.

[10]  P. Yin,et al.  A DNAzyme that walks processively and autonomously along a one-dimensional track. , 2005, Angewandte Chemie.

[11]  J. Reif,et al.  DNA nanotubes self-assembled from triple-crossover tiles as templates for conductive nanowires. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[12]  N. Seeman,et al.  Paranemic crossover DNA: a generalized Holliday structure with applications in nanotechnology. , 2004, Journal of the American Chemical Society.

[13]  J. Reif,et al.  DNA-Templated Self-Assembly of Protein Arrays and Highly Conductive Nanowires , 2003, Science.

[14]  T. LaBean,et al.  Self-assembled DNA Nanotubes , 2007 .

[15]  Chengde Mao,et al.  Symmetry controls the face geometry of DNA polyhedra. , 2009, Journal of the American Chemical Society.

[16]  K. Namba,et al.  DNA prism structures constructed by folding of multiple rectangular arms. , 2009, Journal of the American Chemical Society.

[17]  N. Seeman,et al.  Design and self-assembly of two-dimensional DNA crystals , 1998, Nature.

[18]  P J Sellin,et al.  DNA biosensors based on self-assembled carbon nanotubes. , 2004, Biochemical and biophysical research communications.

[19]  G. Rupper,et al.  Vacuum Rabi splitting with a single quantum dot in a photonic crystal nanocavity , 2004, Nature.

[20]  Erik Winfree,et al.  Molecular robots guided by prescriptive landscapes , 2010, Nature.

[21]  Michael J. Campolongo,et al.  Building plasmonic nanostructures with DNA. , 2011, Nature nanotechnology.

[22]  David R. Liu,et al.  Autonomous Multistep Organic Synthesis in a Single Isothermal Solution Mediated by a DNA Walker , 2010, Nature nanotechnology.

[23]  Chengde Mao,et al.  Self-assembly of hexagonal DNA two-dimensional (2D) arrays. , 2005, Journal of the American Chemical Society.

[24]  Russell P. Goodman,et al.  Reconfigurable, braced, three-dimensional DNA nanostructures. , 2008, Nature nanotechnology.

[25]  C. Mao,et al.  Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra , 2008, Nature.

[26]  J. Kjems,et al.  Self-assembly of a nanoscale DNA box with a controllable lid , 2009, Nature.

[27]  Shawn M. Douglas,et al.  Folding DNA into Twisted and Curved Nanoscale Shapes , 2009, Science.

[28]  Daniel G. Anderson,et al.  Molecularly Self-Assembled Nucleic Acid Nanoparticles for Targeted In Vivo siRNA Delivery , 2012, Nature nanotechnology.

[29]  Pamela E. Constantinou,et al.  From Molecular to Macroscopic via the Rational Design of a Self-Assembled 3D DNA Crystal , 2009, Nature.

[30]  Cees Dekker,et al.  Nanotechnology: Carbon nanotubes with DNA recognition , 2002, Nature.

[31]  J. Reif,et al.  Directed nucleation assembly of DNA tile complexes for barcode-patterned lattices , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[32]  N. Seeman.  DNA in a material world , 2003, Nature.